7EMF

Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000151	cellular_component	ubiquitin ligase complex
0	0003713	molecular_function	transcription coactivator activity
0	0005515	molecular_function	protein binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005667	cellular_component	transcription regulator complex
0	0005730	cellular_component	nucleolus
0	0006351	biological_process	DNA-templated transcription
0	0006357	biological_process	regulation of transcription by RNA polymerase II
0	0006367	biological_process	transcription initiation at RNA polymerase II promoter
0	0016567	biological_process	protein ubiquitination
0	0016592	cellular_component	mediator complex
0	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
0	0051123	biological_process	RNA polymerase II preinitiation complex assembly
0	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
0	0061630	molecular_function	ubiquitin protein ligase activity
1	0003779	molecular_function	actin binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005737	cellular_component	cytoplasm
1	0005856	cellular_component	cytoskeleton
1	0006351	biological_process	DNA-templated transcription
1	0016020	cellular_component	membrane
1	0016592	cellular_component	mediator complex
1	0030864	cellular_component	cortical actin cytoskeleton
1	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
1	0051123	biological_process	RNA polymerase II preinitiation complex assembly
1	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
2	0003712	molecular_function	transcription coregulator activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0006351	biological_process	DNA-templated transcription
2	0006357	biological_process	regulation of transcription by RNA polymerase II
2	0016592	cellular_component	mediator complex
2	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
2	0051123	biological_process	RNA polymerase II preinitiation complex assembly
2	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
3	0000151	cellular_component	ubiquitin ligase complex
3	0003712	molecular_function	transcription coregulator activity
3	0003713	molecular_function	transcription coactivator activity
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0006351	biological_process	DNA-templated transcription
3	0016567	biological_process	protein ubiquitination
3	0016592	cellular_component	mediator complex
3	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
3	0042809	molecular_function	nuclear vitamin D receptor binding
3	0045893	biological_process	positive regulation of DNA-templated transcription
3	0046966	molecular_function	nuclear thyroid hormone receptor binding
3	0051123	biological_process	RNA polymerase II preinitiation complex assembly
3	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
3	0061630	molecular_function	ubiquitin protein ligase activity
4	0000151	cellular_component	ubiquitin ligase complex
4	0003712	molecular_function	transcription coregulator activity
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0006351	biological_process	DNA-templated transcription
4	0006355	biological_process	regulation of DNA-templated transcription
4	0006357	biological_process	regulation of transcription by RNA polymerase II
4	0016567	biological_process	protein ubiquitination
4	0016592	cellular_component	mediator complex
4	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
4	0051123	biological_process	RNA polymerase II preinitiation complex assembly
4	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
4	0061630	molecular_function	ubiquitin protein ligase activity
4	0070847	cellular_component	core mediator complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000151	cellular_component	ubiquitin ligase complex
A	0000785	cellular_component	chromatin
A	0000902	biological_process	cell morphogenesis
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0001223	molecular_function	transcription coactivator binding
A	0001525	biological_process	angiogenesis
A	0002088	biological_process	lens development in camera-type eye
A	0002154	biological_process	thyroid hormone receptor signaling pathway
A	0003222	biological_process	ventricular trabecula myocardium morphogenesis
A	0003406	biological_process	retinal pigment epithelium development
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003712	molecular_function	transcription coregulator activity
A	0003713	molecular_function	transcription coactivator activity
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0006351	biological_process	DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006702	biological_process	androgen biosynthetic process
A	0010628	biological_process	positive regulation of gene expression
A	0010839	biological_process	negative regulation of keratinocyte proliferation
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016592	cellular_component	mediator complex
A	0016922	molecular_function	nuclear receptor binding
A	0030216	biological_process	keratinocyte differentiation
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0030518	biological_process	nuclear receptor-mediated steroid hormone signaling pathway
A	0031490	molecular_function	chromatin DNA binding
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0032993	cellular_component	protein-DNA complex
A	0035035	molecular_function	histone acetyltransferase binding
A	0035855	biological_process	megakaryocyte development
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0042809	molecular_function	nuclear vitamin D receptor binding
A	0042974	molecular_function	nuclear retinoic acid receptor binding
A	0042975	molecular_function	peroxisome proliferator activated receptor binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0044877	molecular_function	protein-containing complex binding
A	0045444	biological_process	fat cell differentiation
A	0045618	biological_process	positive regulation of keratinocyte differentiation
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045665	biological_process	negative regulation of neuron differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046966	molecular_function	nuclear thyroid hormone receptor binding
A	0048821	biological_process	erythrocyte development
A	0050693	molecular_function	LBD domain binding
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0071364	biological_process	cellular response to epidermal growth factor stimulus
A	0071383	biological_process	cellular response to steroid hormone stimulus
A	0097067	biological_process	cellular response to thyroid hormone stimulus
A	0140296	molecular_function	general transcription initiation factor binding
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1990841	molecular_function	promoter-specific chromatin binding
A	2001141	biological_process	regulation of RNA biosynthetic process
D	0003712	molecular_function	transcription coregulator activity
D	0003713	molecular_function	transcription coactivator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006351	biological_process	DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006366	biological_process	transcription by RNA polymerase II
D	0016020	cellular_component	membrane
D	0016592	cellular_component	mediator complex
D	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
D	0042809	molecular_function	nuclear vitamin D receptor binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046966	molecular_function	nuclear thyroid hormone receptor binding
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0070847	cellular_component	core mediator complex
F	0001223	molecular_function	transcription coactivator binding
F	0003677	molecular_function	DNA binding
F	0003712	molecular_function	transcription coregulator activity
F	0003713	molecular_function	transcription coactivator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0006351	biological_process	DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016020	cellular_component	membrane
F	0016592	cellular_component	mediator complex
F	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0070847	cellular_component	core mediator complex
G	0000151	cellular_component	ubiquitin ligase complex
G	0003712	molecular_function	transcription coregulator activity
G	0003713	molecular_function	transcription coactivator activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005667	cellular_component	transcription regulator complex
G	0006351	biological_process	DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0016567	biological_process	protein ubiquitination
G	0016592	cellular_component	mediator complex
G	0016604	cellular_component	nuclear body
G	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0061630	molecular_function	ubiquitin protein ligase activity
H	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
H	0003712	molecular_function	transcription coregulator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0006351	biological_process	DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0016567	biological_process	protein ubiquitination
H	0016592	cellular_component	mediator complex
H	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0070847	cellular_component	core mediator complex
I	0003712	molecular_function	transcription coregulator activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0006351	biological_process	DNA-templated transcription
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0016592	cellular_component	mediator complex
I	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0000151	cellular_component	ubiquitin ligase complex
J	0003712	molecular_function	transcription coregulator activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0006351	biological_process	DNA-templated transcription
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0016567	biological_process	protein ubiquitination
J	0016592	cellular_component	mediator complex
J	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
J	0051123	biological_process	RNA polymerase II preinitiation complex assembly
J	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0061630	molecular_function	ubiquitin protein ligase activity
K	0000151	cellular_component	ubiquitin ligase complex
K	0003712	molecular_function	transcription coregulator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0006351	biological_process	DNA-templated transcription
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0016567	biological_process	protein ubiquitination
K	0016592	cellular_component	mediator complex
K	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
K	0061630	molecular_function	ubiquitin protein ligase activity
N	0003712	molecular_function	transcription coregulator activity
N	0003713	molecular_function	transcription coactivator activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0006351	biological_process	DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0016020	cellular_component	membrane
N	0016592	cellular_component	mediator complex
N	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
N	0042809	molecular_function	nuclear vitamin D receptor binding
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0051123	biological_process	RNA polymerase II preinitiation complex assembly
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0070847	cellular_component	core mediator complex
O	0003712	molecular_function	transcription coregulator activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0006351	biological_process	DNA-templated transcription
O	0006355	biological_process	regulation of DNA-templated transcription
O	0016020	cellular_component	membrane
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0070847	cellular_component	core mediator complex
P	0003713	molecular_function	transcription coactivator activity
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0006351	biological_process	DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006366	biological_process	transcription by RNA polymerase II
P	0016020	cellular_component	membrane
P	0016592	cellular_component	mediator complex
P	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
P	0042809	molecular_function	nuclear vitamin D receptor binding
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0046966	molecular_function	nuclear thyroid hormone receptor binding
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0000151	cellular_component	ubiquitin ligase complex
Q	0003712	molecular_function	transcription coregulator activity
Q	0003713	molecular_function	transcription coactivator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005667	cellular_component	transcription regulator complex
Q	0006351	biological_process	DNA-templated transcription
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0016020	cellular_component	membrane
Q	0016567	biological_process	protein ubiquitination
Q	0016592	cellular_component	mediator complex
Q	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Q	0042809	molecular_function	nuclear vitamin D receptor binding
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0046966	molecular_function	nuclear thyroid hormone receptor binding
Q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0061630	molecular_function	ubiquitin protein ligase activity
Q	0070847	cellular_component	core mediator complex
R	0003712	molecular_function	transcription coregulator activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0006351	biological_process	DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0016592	cellular_component	mediator complex
R	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0070847	cellular_component	core mediator complex
S	0003712	molecular_function	transcription coregulator activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0006351	biological_process	DNA-templated transcription
S	0006357	biological_process	regulation of transcription by RNA polymerase II
S	0016592	cellular_component	mediator complex
S	0016604	cellular_component	nuclear body
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	0051123	biological_process	RNA polymerase II preinitiation complex assembly
S	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
T	0003712	molecular_function	transcription coregulator activity
T	0003713	molecular_function	transcription coactivator activity
T	0003899	molecular_function	DNA-directed RNA polymerase activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0006351	biological_process	DNA-templated transcription
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0006366	biological_process	transcription by RNA polymerase II
T	0016592	cellular_component	mediator complex
T	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
T	0032991	cellular_component	protein-containing complex
T	0051123	biological_process	RNA polymerase II preinitiation complex assembly
T	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0000151	cellular_component	ubiquitin ligase complex
U	0003712	molecular_function	transcription coregulator activity
U	0003713	molecular_function	transcription coactivator activity
U	0003899	molecular_function	DNA-directed RNA polymerase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0006351	biological_process	DNA-templated transcription
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0016567	biological_process	protein ubiquitination
U	0016592	cellular_component	mediator complex
U	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0051123	biological_process	RNA polymerase II preinitiation complex assembly
U	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0061630	molecular_function	ubiquitin protein ligase activity
V	0003712	molecular_function	transcription coregulator activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0006351	biological_process	DNA-templated transcription
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0016592	cellular_component	mediator complex
V	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
V	0051123	biological_process	RNA polymerase II preinitiation complex assembly
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
W	0003713	molecular_function	transcription coactivator activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005667	cellular_component	transcription regulator complex
W	0006351	biological_process	DNA-templated transcription
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
W	0010628	biological_process	positive regulation of gene expression
W	0016592	cellular_component	mediator complex
W	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
W	0051123	biological_process	RNA polymerase II preinitiation complex assembly
W	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
X	0003712	molecular_function	transcription coregulator activity
X	0003713	molecular_function	transcription coactivator activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0006351	biological_process	DNA-templated transcription
X	0016592	cellular_component	mediator complex
X	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
X	0042809	molecular_function	nuclear vitamin D receptor binding
X	0045893	biological_process	positive regulation of DNA-templated transcription
X	0046966	molecular_function	nuclear thyroid hormone receptor binding
X	0051123	biological_process	RNA polymerase II preinitiation complex assembly
X	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Y	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Y	0001223	molecular_function	transcription coactivator binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005667	cellular_component	transcription regulator complex
Y	0006351	biological_process	DNA-templated transcription
Y	0016592	cellular_component	mediator complex
Y	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Y	0035563	biological_process	positive regulation of chromatin binding
Y	0042974	molecular_function	nuclear retinoic acid receptor binding
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0046965	molecular_function	nuclear retinoid X receptor binding
Y	0048147	biological_process	negative regulation of fibroblast proliferation
Y	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Y	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Y	2001178	biological_process	positive regulation of mediator complex assembly
Z	0003712	molecular_function	transcription coregulator activity
Z	0003713	molecular_function	transcription coactivator activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0006351	biological_process	DNA-templated transcription
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Z	0010628	biological_process	positive regulation of gene expression
Z	0016592	cellular_component	mediator complex
Z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Z	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Z	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Z	0070847	cellular_component	core mediator complex

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. SSGMKSSSGLGSSGSL

Chain	Residue	Details
A	SER1240-LEU1255

---

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. MKsSsGLGSSGS

Chain	Residue	Details
A	MET1243-SER1254

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	157
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Region: {"description":"Interaction with the Elongin BC complex"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"LXXLL motif 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	50
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	47
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	45
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	37
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	53
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI13
Number of Residues	34
Details	Repeat: {"description":"WD 9"}

Chain

Residue

Details

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site_id	SWS_FT_FI14
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI15
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI16
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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