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7EJ0

Structure of the alpha2A-adrenergic receptor GoA signaling complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0006904biological_processvesicle docking involved in exocytosis
A0006936biological_processmuscle contraction
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
A0007212biological_processG protein-coupled dopamine receptor signaling pathway
A0007626biological_processlocomotory behavior
A0008016biological_processregulation of heart contraction
A0010854molecular_functionadenylate cyclase regulator activity
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0030425cellular_componentdendrite
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0031852molecular_functionmu-type opioid receptor binding
A0042734cellular_componentpresynaptic membrane
A0044297cellular_componentcell body
A0045211cellular_componentpostsynaptic membrane
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0051430molecular_functioncorticotropin-releasing hormone receptor 1 binding
A0098688cellular_componentparallel fiber to Purkinje cell synapse
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0045202cellular_componentsynapse
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001819biological_processpositive regulation of cytokine production
R0004930molecular_functionG protein-coupled receptor activity
R0004935molecular_functionadrenergic receptor activity
R0004938molecular_functionalpha2-adrenergic receptor activity
R0005085molecular_functionguanyl-nucleotide exchange factor activity
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005886cellular_componentplasma membrane
R0006260biological_processDNA replication
R0006940biological_processregulation of smooth muscle contraction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007265biological_processRas protein signal transduction
R0007266biological_processRho protein signal transduction
R0007565biological_processfemale pregnancy
R0008284biological_processpositive regulation of cell population proliferation
R0010700biological_processnegative regulation of norepinephrine secretion
R0016020cellular_componentmembrane
R0016323cellular_componentbasolateral plasma membrane
R0019229biological_processregulation of vasoconstriction
R0019901molecular_functionprotein kinase binding
R0030036biological_processactin cytoskeleton organization
R0030168biological_processplatelet activation
R0030335biological_processpositive regulation of cell migration
R0031692molecular_functionalpha-1B adrenergic receptor binding
R0031696molecular_functionalpha-2C adrenergic receptor binding
R0031996molecular_functionthioesterase binding
R0032147biological_processactivation of protein kinase activity
R0032148biological_processactivation of protein kinase B activity
R0032795molecular_functionheterotrimeric G-protein binding
R0032811biological_processnegative regulation of epinephrine secretion
R0032870biological_processcellular response to hormone stimulus
R0035624biological_processreceptor transactivation
R0042311biological_processvasodilation
R0042593biological_processglucose homeostasis
R0042596biological_processfear response
R0042803molecular_functionprotein homodimerization activity
R0043025cellular_componentneuronal cell body
R0043235cellular_componentreceptor complex
R0043268biological_processpositive regulation of potassium ion transport
R0043278biological_processresponse to morphine
R0043406biological_processpositive regulation of MAP kinase activity
R0043410biological_processpositive regulation of MAPK cascade
R0043679cellular_componentaxon terminus
R0045211cellular_componentpostsynaptic membrane
R0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
R0045955biological_processnegative regulation of calcium ion-dependent exocytosis
R0046676biological_processnegative regulation of insulin secretion
R0046982molecular_functionprotein heterodimerization activity
R0048787cellular_componentpresynaptic active zone membrane
R0050892biological_processintestinal absorption
R0050955biological_processthermoception
R0050995biological_processnegative regulation of lipid catabolic process
R0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
R0051379molecular_functionepinephrine binding
R0051380molecular_functionnorepinephrine binding
R0051926biological_processnegative regulation of calcium ion transport
R0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
R0070473biological_processnegative regulation of uterine smooth muscle contraction
R0071875biological_processadrenergic receptor signaling pathway
R0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
R0071881biological_processadenylate cyclase-inhibiting adrenergic receptor signaling pathway
R0071882biological_processphospholipase C-activating adrenergic receptor signaling pathway
R0090303biological_processpositive regulation of wound healing
R0097305biological_processresponse to alcohol
R0098691cellular_componentdopaminergic synapse
R0098839cellular_componentpostsynaptic density membrane
R0098978cellular_componentglutamatergic synapse
R0098982cellular_componentGABA-ergic synapse
R0099171biological_processpresynaptic modulation of chemical synaptic transmission
R1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIvHLCAISLDRYWsI
ChainResidueDetails
RSER134-ILE150

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues90
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
RMET1-THR48
ATHR182
AASN270
AASP273
ACYS325
RGLY112-CYS121
RGLU188-LYS209
RLEU411-LYS424
ASER152
ALEU176
AARG177
ATHR178
AARG179

site_idSWS_FT_FI2
Number of Residues25
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250
ChainResidueDetails
RLEU49-PHE74

site_idSWS_FT_FI3
Number of Residues207
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
RTHR75-LEU85
RASP145-LYS166
RARG233-PHE389
RASN445-VAL465

site_idSWS_FT_FI4
Number of Residues25
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250
ChainResidueDetails
RPHE86-MET111

site_idSWS_FT_FI5
Number of Residues22
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250
ChainResidueDetails
RGLU122-LEU144

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250
ChainResidueDetails
RALA167-ILE187

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250
ChainResidueDetails
RTRP210-VAL232

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250
ChainResidueDetails
RVAL390-THR410

site_idSWS_FT_FI9
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250
ChainResidueDetails
RPHE425-PHE444

site_idSWS_FT_FI10
Number of Residues1
DetailsSITE: Implicated in ligand binding
ChainResidueDetails
RASP128

site_idSWS_FT_FI11
Number of Residues2
DetailsSITE: Implicated in catechol agonist binding and receptor activation
ChainResidueDetails
RSER215
RSER219

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P22909
ChainResidueDetails
RSER346

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q01338
ChainResidueDetails
RARG368

site_idSWS_FT_FI14
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
RCYS457

site_idSWS_FT_FI15
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN25
RASN29

227111

PDB entries from 2024-11-06

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