7EHM

Human MTHFD2 in complex with compound 21 and 15

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
A	0004487	molecular_function	methylenetetrahydrofolate dehydrogenase (NAD+) activity
A	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006730	biological_process	one-carbon metabolic process
A	0015943	biological_process	formate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016787	molecular_function	hydrolase activity
A	0035999	biological_process	tetrahydrofolate interconversion
A	0042301	molecular_function	phosphate ion binding
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046655	biological_process	folic acid metabolic process
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
B	0004487	molecular_function	methylenetetrahydrofolate dehydrogenase (NAD+) activity
B	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006730	biological_process	one-carbon metabolic process
B	0015943	biological_process	formate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016787	molecular_function	hydrolase activity
B	0035999	biological_process	tetrahydrofolate interconversion
B	0042301	molecular_function	phosphate ion binding
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0046655	biological_process	folic acid metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00766
Number of Residues	26
Details	THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EeELLnlInkLNnDdnvdgLLVQLPL

Chain	Residue	Details
A	GLU110-LEU135

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site_id	PS00767
Number of Residues	9
Details	THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV

Chain	Residue	Details
A	PRO309-VAL317

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27899380","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16100107","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27899380","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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