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7EHM

Human MTHFD2 in complex with compound 21 and 15

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003824molecular_functioncatalytic activity
A0004477molecular_functionmethenyltetrahydrofolate cyclohydrolase activity
A0004487molecular_functionmethylenetetrahydrofolate dehydrogenase (NAD+) activity
A0004488molecular_functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006730biological_processone-carbon metabolic process
A0016491molecular_functionoxidoreductase activity
A0016787molecular_functionhydrolase activity
A0035999biological_processtetrahydrofolate interconversion
A0042301molecular_functionphosphate ion binding
A0046653biological_processtetrahydrofolate metabolic process
A0046655biological_processfolic acid metabolic process
B0000287molecular_functionmagnesium ion binding
B0003824molecular_functioncatalytic activity
B0004477molecular_functionmethenyltetrahydrofolate cyclohydrolase activity
B0004487molecular_functionmethylenetetrahydrofolate dehydrogenase (NAD+) activity
B0004488molecular_functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006730biological_processone-carbon metabolic process
B0016491molecular_functionoxidoreductase activity
B0016787molecular_functionhydrolase activity
B0035999biological_processtetrahydrofolate interconversion
B0042301molecular_functionphosphate ion binding
B0046653biological_processtetrahydrofolate metabolic process
B0046655biological_processfolic acid metabolic process
Functional Information from PROSITE/UniProt
site_idPS00766
Number of Residues26
DetailsTHF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EeELLnlInkLNnDdnvdgLLVQLPL
ChainResidueDetails
AGLU110-LEU135

site_idPS00767
Number of Residues9
DetailsTHF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV
ChainResidueDetails
APRO309-VAL317

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:27899380
ChainResidueDetails
ATYR84
AVAL131
APRO309
BTYR84
BVAL131
BPRO309

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:16100107, ECO:0000269|PubMed:27899380
ChainResidueDetails
AGLY200
AARG233
BGLY200
BARG233

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS50
BLYS50

site_idSWS_FT_FI4
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS50
BLYS50

222415

PDB entries from 2024-07-10

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