7EGP

The structure of SWI/SNF-nucleosome complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0042393	molecular_function	histone binding
B	0003677	molecular_function	DNA binding
C	0000228	cellular_component	nuclear chromosome
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000785	cellular_component	chromatin
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006338	biological_process	chromatin remodeling
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016514	cellular_component	SWI/SNF complex
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0045991	biological_process	carbon catabolite activation of transcription
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016514	cellular_component	SWI/SNF complex
D	0031496	biological_process	positive regulation of mating type switching
D	0042393	molecular_function	histone binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0000785	cellular_component	chromatin
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005829	cellular_component	cytosol
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0016514	cellular_component	SWI/SNF complex
E	0031496	biological_process	positive regulation of mating type switching
E	0042393	molecular_function	histone binding
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0000785	cellular_component	chromatin
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005829	cellular_component	cytosol
H	0006338	biological_process	chromatin remodeling
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0016514	cellular_component	SWI/SNF complex
H	0030527	molecular_function	structural constituent of chromatin
H	0034198	biological_process	cellular response to amino acid starvation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0000182	molecular_function	rDNA binding
I	0000470	biological_process	maturation of LSU-rRNA
I	0000785	cellular_component	chromatin
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005829	cellular_component	cytosol
I	0006289	biological_process	nucleotide-excision repair
I	0006338	biological_process	chromatin remodeling
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0016514	cellular_component	SWI/SNF complex
I	0045943	biological_process	positive regulation of transcription by RNA polymerase I
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0000785	cellular_component	chromatin
J	0003674	molecular_function	molecular_function
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005829	cellular_component	cytosol
J	0006325	biological_process	chromatin organization
J	0006338	biological_process	chromatin remodeling
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0016514	cellular_component	SWI/SNF complex
J	0016586	cellular_component	RSC-type complex
J	0031490	molecular_function	chromatin DNA binding
L	0000785	cellular_component	chromatin
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006337	biological_process	nucleosome disassembly
L	0006338	biological_process	chromatin remodeling
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0007059	biological_process	chromosome segregation
L	0015616	molecular_function	DNA translocase activity
L	0016514	cellular_component	SWI/SNF complex
L	0016586	cellular_component	RSC-type complex
M	0000785	cellular_component	chromatin
M	0003674	molecular_function	molecular_function
M	0003682	molecular_function	chromatin binding
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0006325	biological_process	chromatin organization
M	0006337	biological_process	nucleosome disassembly
M	0006338	biological_process	chromatin remodeling
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0016514	cellular_component	SWI/SNF complex
M	0016586	cellular_component	RSC-type complex
M	0035267	cellular_component	NuA4 histone acetyltransferase complex
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0000785	cellular_component	chromatin
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0006325	biological_process	chromatin organization
N	0006337	biological_process	nucleosome disassembly
N	0006338	biological_process	chromatin remodeling
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006368	biological_process	transcription elongation by RNA polymerase II
N	0016514	cellular_component	SWI/SNF complex
N	0016586	cellular_component	RSC-type complex
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0030527	molecular_function	structural constituent of chromatin
O	0046982	molecular_function	protein heterodimerization activity
P	0000786	cellular_component	nucleosome
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005694	cellular_component	chromosome
P	0006334	biological_process	nucleosome assembly
P	0030527	molecular_function	structural constituent of chromatin
P	0046982	molecular_function	protein heterodimerization activity
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0030527	molecular_function	structural constituent of chromatin
Q	0031507	biological_process	heterochromatin formation
Q	0046982	molecular_function	protein heterodimerization activity
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005694	cellular_component	chromosome
R	0030527	molecular_function	structural constituent of chromatin
R	0046982	molecular_function	protein heterodimerization activity
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005694	cellular_component	chromosome
S	0030527	molecular_function	structural constituent of chromatin
S	0046982	molecular_function	protein heterodimerization activity
T	0000786	cellular_component	nucleosome
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005694	cellular_component	chromosome
T	0006334	biological_process	nucleosome assembly
T	0030527	molecular_function	structural constituent of chromatin
T	0046982	molecular_function	protein heterodimerization activity
U	0000786	cellular_component	nucleosome
U	0003677	molecular_function	DNA binding
U	0005634	cellular_component	nucleus
U	0005694	cellular_component	chromosome
U	0030527	molecular_function	structural constituent of chromatin
U	0031507	biological_process	heterochromatin formation
U	0046982	molecular_function	protein heterodimerization activity
V	0000786	cellular_component	nucleosome
V	0003677	molecular_function	DNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005694	cellular_component	chromosome
V	0030527	molecular_function	structural constituent of chromatin
V	0046982	molecular_function	protein heterodimerization activity

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
Q	ALA21-VAL27

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site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
P	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
O	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
R	ARG89-GLY111

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
O	PRO66-ILE74

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
L	SER77
D	SER185
D	SER657
E	SER88
E	SER185
E	SER657
V	LYS12
V	LYS17

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198

Chain	Residue	Details
L	SER122
E	THR235

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER1340
V	SER109

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS543
T	LYS5
V	LYS117

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	LYS8
P	LYS16
P	LYS44
P	LYS79
T	LYS8
T	LYS16
T	LYS44
T	LYS79

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	LYS12
P	LYS20
T	LYS12
T	LYS20

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	LYS31
P	LYS91
T	LYS31
T	LYS91

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PAK2 => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	SER47
T	SER47

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	TYR51
P	TYR88
T	TYR51
T	TYR88

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	LYS59
S	LYS64
T	LYS59
O	LYS27
O	LYS36
O	LYS64
S	LYS18
S	LYS23
S	LYS27
S	LYS36

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	LYS77
T	LYS77

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	LYS31
T	LYS31

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
O	LYS37
P	LYS91
T	LYS91

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	TYR41
S	TYR41

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
O	LYS56
O	LYS79
S	LYS56
S	LYS79

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	SER57
S	SER57

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	THR80
O	THR107
S	THR80
S	THR107

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
O	SER86
S	SER86

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	LYS115
S	LYS115

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	LYS122
S	LYS122

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	CYS110
S	CYS110

---