7ECT

Crystal Structure of Aspergillus terreus Glutamate Dehydrogenase (AtGDH) Complexed With Tartrate and NADPH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
A	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0006537	biological_process	glutamate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
B	0000166	molecular_function	nucleotide binding
B	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
B	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0006537	biological_process	glutamate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
C	0000166	molecular_function	nucleotide binding
C	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
C	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0006537	biological_process	glutamate biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue NDP A 501

Chain	Residue
A	ARG82
A	GLY230
A	ASN231
A	VAL232
A	SER251
A	ASP252
A	SER253
A	LYS279
A	GLN284
A	SER319
A	ALA320
A	LYS122
A	THR321
A	GLY344
A	SER345
A	ASN346
A	ASN379
A	GOL504
A	GOL505
A	TLA507
A	HOH605
A	ASP154
A	ILE155
A	GLY156
A	ARG193
A	THR197
A	GLY228
A	SER229

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 502

Chain	Residue
A	ARG142
A	ILE144
A	THR148
A	ARG173
B	ASN174

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 503

Chain	Residue
A	TRP399
A	GLU403
A	ARG407

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 504

Chain	Residue
A	ASP252
A	SER253
A	GLN254
A	GLY255
A	GLN304
A	NDP501

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 505

Chain	Residue
A	GLY153
A	VAL157
A	ARG193
A	NDP501

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL A 506

Chain	Residue
A	GLN12
A	THR350
A	GLN351

---

site_id	AC7
Number of Residues	14
Details	binding site for residue TLA A 507

Chain	Residue
A	LYS78
A	GLY79
A	GLY80
A	GLN99
A	LYS102
A	LYS114
A	ALA152
A	GLY153
A	THR181
A	ARG193
A	ASN346
A	VAL383
A	SER386
A	NDP501

---

site_id	AC8
Number of Residues	25
Details	binding site for residue NDP B 501

Chain	Residue
B	ARG82
B	HIS84
B	LYS122
B	ASP154
B	ILE155
B	GLY156
B	ARG193
B	THR197
B	SER229
B	GLY230
B	ASN231
B	VAL232
B	ASP252
B	SER253
B	LYS279
B	GLN284
B	SER319
B	ALA320
B	THR321
B	GLY344
B	SER345
B	ASN346
B	ASN379
B	TLA503
B	HOH602

---

site_id	AC9
Number of Residues	3
Details	binding site for residue GOL B 502

Chain	Residue
B	TRP399
B	GLU403
B	ARG407

---

site_id	AD1
Number of Residues	15
Details	binding site for residue TLA B 503

Chain	Residue
B	ASP154
B	THR181
B	ARG193
B	ASN346
B	VAL383
B	SER386
B	NDP501
B	LYS78
B	GLY79
B	GLY80
B	GLN99
B	LYS102
B	LYS114
B	ALA152
B	GLY153

---

site_id	AD2
Number of Residues	24
Details	binding site for residue NDP C 501

Chain	Residue
C	ARG82
C	HIS84
C	LYS122
C	GLY153
C	ASP154
C	ILE155
C	GLY156
C	ARG193
C	THR197
C	SER229
C	GLY230
C	ASN231
C	VAL232
C	ASP252
C	SER253
C	LYS279
C	GLN284
C	ALA320
C	THR321
C	GLY344
C	SER345
C	ASN346
C	ASN379
C	TLA508

---

site_id	AD3
Number of Residues	3
Details	binding site for residue GOL C 502

Chain	Residue
C	TRP399
C	GLU403
C	ARG407

---

site_id	AD4
Number of Residues	5
Details	binding site for residue GOL C 503

Chain	Residue
C	ASP252
C	SER253
C	GLY303
C	GLN304
C	ARG305

---

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL C 504

Chain	Residue
B	ARG142
B	ILE144
B	THR148
B	ARG173
C	ARG142
C	ASN174

---

site_id	AD6
Number of Residues	4
Details	binding site for residue GOL C 505

Chain	Residue
B	ARG142
B	HIS143
C	ARG142
C	HIS143

---

site_id	AD7
Number of Residues	4
Details	binding site for residue GOL C 506

Chain	Residue
B	ASP147
C	ALA146
C	GLY178
C	ASN393

---

site_id	AD8
Number of Residues	1
Details	binding site for residue GOL C 507

Chain	Residue
C	GLY244

---

site_id	AD9
Number of Residues	14
Details	binding site for residue TLA C 508

Chain	Residue
C	LYS78
C	GLY80
C	GLN99
C	LYS102
C	LYS114
C	ALA152
C	GLY153
C	ASP154
C	ARG193
C	ASN346
C	GLY382
C	VAL383
C	SER386
C	NDP501

---

Functional Information from PROSITE/UniProt

site_id	PS00074
Number of Residues	14
Details	GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LnmGGGKgGsdfDP

Chain	Residue	Details
A	LEU108-PRO121

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