7ECR
Crystal Structure of Aspergillus terreus Glutamate Dehydrogenase (AtGDH) Complexed With Succinate and ADP-ribose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006537 | biological_process | glutamate biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006537 | biological_process | glutamate biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006537 | biological_process | glutamate biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | ARG142 |
| A | ILE144 |
| A | THR148 |
| A | GOL505 |
| A | GOL505 |
| A | HOH613 |
| A | HOH660 |
| B | ASN174 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ARG407 |
| A | HOH648 |
| A | HOH884 |
| A | HOH954 |
| A | TRP399 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | LEU105 |
| A | SER414 |
| A | ASN418 |
| A | LYS448 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | SER398 |
| A | GLU403 |
| A | HOH630 |
| A | HOH648 |
| A | HOH839 |
| C | ARG407 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | ARG142 |
| A | ARG142 |
| A | HIS143 |
| A | GOL501 |
| A | GOL501 |
| A | HOH603 |
| A | HOH603 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue SIN A 506 |
| Chain | Residue |
| A | LYS78 |
| A | GLY79 |
| A | GLY80 |
| A | GLN99 |
| A | LYS102 |
| A | LYS114 |
| A | ALA152 |
| A | ARG193 |
| A | ASN379 |
| A | VAL383 |
| A | SER386 |
| A | HOH654 |
| A | HOH820 |
| site_id | AC7 |
| Number of Residues | 34 |
| Details | binding site for residue A2R A 507 |
| Chain | Residue |
| A | ARG82 |
| A | HIS84 |
| A | LYS122 |
| A | ASP154 |
| A | ILE155 |
| A | GLY156 |
| A | SER229 |
| A | GLY230 |
| A | ASN231 |
| A | VAL232 |
| A | ASP252 |
| A | SER253 |
| A | LYS279 |
| A | GLN284 |
| A | SER319 |
| A | ALA320 |
| A | THR321 |
| A | GLY344 |
| A | SER345 |
| A | ASN346 |
| A | ASN379 |
| A | HOH601 |
| A | HOH610 |
| A | HOH654 |
| A | HOH664 |
| A | HOH679 |
| A | HOH690 |
| A | HOH753 |
| A | HOH800 |
| A | HOH821 |
| A | HOH826 |
| A | HOH832 |
| A | HOH876 |
| A | HOH922 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 508 |
| Chain | Residue |
| A | GLN12 |
| A | ASN323 |
| A | THR350 |
| A | GLN351 |
| A | HOH784 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | TRP399 |
| B | GLU403 |
| B | ARG407 |
| B | GOL503 |
| B | HOH615 |
| B | HOH788 |
| B | HOH923 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | LEU105 |
| B | SER414 |
| B | ASN418 |
| B | LYS448 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| A | ARG407 |
| B | SER398 |
| B | GLU403 |
| B | GOL501 |
| B | HOH659 |
| B | HOH788 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | ARG142 |
| B | ILE144 |
| B | THR148 |
| B | HOH601 |
| C | ASN174 |
| C | GOL506 |
| C | HOH832 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue SIN B 505 |
| Chain | Residue |
| B | LYS78 |
| B | GLY79 |
| B | GLY80 |
| B | GLN99 |
| B | LYS102 |
| B | LYS114 |
| B | ALA152 |
| B | ARG193 |
| B | ASN379 |
| B | VAL383 |
| B | SER386 |
| B | HOH627 |
| B | HOH808 |
| site_id | AD5 |
| Number of Residues | 35 |
| Details | binding site for residue A2R B 506 |
| Chain | Residue |
| B | ARG82 |
| B | HIS84 |
| B | LYS122 |
| B | ASP154 |
| B | ILE155 |
| B | GLY156 |
| B | SER229 |
| B | GLY230 |
| B | ASN231 |
| B | VAL232 |
| B | SER251 |
| B | ASP252 |
| B | SER253 |
| B | LYS279 |
| B | GLN284 |
| B | SER319 |
| B | ALA320 |
| B | THR321 |
| B | GLY344 |
| B | SER345 |
| B | ASN346 |
| B | ASN379 |
| B | HOH627 |
| B | HOH668 |
| B | HOH675 |
| B | HOH686 |
| B | HOH707 |
| B | HOH711 |
| B | HOH722 |
| B | HOH737 |
| B | HOH759 |
| B | HOH819 |
| B | HOH846 |
| B | HOH861 |
| B | HOH864 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 507 |
| Chain | Residue |
| B | GLN12 |
| B | ASN323 |
| B | THR350 |
| B | GLN351 |
| B | HOH684 |
| B | HOH806 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 508 |
| Chain | Residue |
| B | GLU217 |
| B | ALA220 |
| B | GLY221 |
| B | LYS222 |
| B | HOH712 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| A | ASN174 |
| C | ARG142 |
| C | ILE144 |
| C | THR148 |
| C | GOL506 |
| C | HOH604 |
| C | HOH649 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| C | TRP399 |
| C | GLU403 |
| C | ARG407 |
| C | GOL504 |
| C | HOH616 |
| C | HOH709 |
| C | HOH884 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | LEU105 |
| C | GLY107 |
| C | SER414 |
| C | ASN418 |
| C | LYS448 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| B | ARG407 |
| C | SER398 |
| C | TRP399 |
| C | GLU403 |
| C | GOL502 |
| C | HOH709 |
| site_id | AE3 |
| Number of Residues | 12 |
| Details | binding site for residue GOL C 505 |
| Chain | Residue |
| C | HIS211 |
| C | LYS365 |
| C | GLY366 |
| C | ASP431 |
| C | GLY432 |
| C | GLY432 |
| C | ILE433 |
| C | PRO435 |
| C | HOH639 |
| C | HOH639 |
| C | HOH823 |
| C | HOH868 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 506 |
| Chain | Residue |
| B | ARG142 |
| B | GOL504 |
| C | ARG142 |
| C | HIS143 |
| C | GOL501 |
| C | HOH640 |
| C | HOH658 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 507 |
| Chain | Residue |
| C | ASP252 |
| C | SER253 |
| C | GLY303 |
| C | GLN304 |
| C | HOH603 |
| C | HOH812 |
| site_id | AE6 |
| Number of Residues | 13 |
| Details | binding site for residue SIN C 508 |
| Chain | Residue |
| C | LYS78 |
| C | GLY79 |
| C | GLY80 |
| C | GLN99 |
| C | LYS102 |
| C | LYS114 |
| C | ALA152 |
| C | ARG193 |
| C | ASN379 |
| C | VAL383 |
| C | SER386 |
| C | HOH675 |
| C | HOH787 |
| site_id | AE7 |
| Number of Residues | 34 |
| Details | binding site for residue A2R C 509 |
| Chain | Residue |
| C | ARG82 |
| C | HIS84 |
| C | LYS122 |
| C | ASP154 |
| C | ILE155 |
| C | GLY156 |
| C | SER229 |
| C | GLY230 |
| C | ASN231 |
| C | VAL232 |
| C | ASP252 |
| C | SER253 |
| C | LYS279 |
| C | GLN284 |
| C | SER319 |
| C | ALA320 |
| C | THR321 |
| C | GLY344 |
| C | SER345 |
| C | ASN346 |
| C | ASN379 |
| C | HOH632 |
| C | HOH654 |
| C | HOH675 |
| C | HOH718 |
| C | HOH719 |
| C | HOH742 |
| C | HOH791 |
| C | HOH804 |
| C | HOH814 |
| C | HOH838 |
| C | HOH874 |
| C | HOH880 |
| C | HOH926 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 510 |
| Chain | Residue |
| C | GLN12 |
| C | ASN323 |
| C | GLN351 |
| C | HOH621 |
| C | HOH829 |
Functional Information from PROSITE/UniProt
| site_id | PS00074 |
| Number of Residues | 14 |
| Details | GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LnmGGGKgGsdfDP |
| Chain | Residue | Details |
| A | LEU108-PRO121 |
