7E8H

CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0016020	cellular_component	membrane
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0016020	cellular_component	membrane
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
E	0005509	molecular_function	calcium ion binding
F	0005509	molecular_function	calcium ion binding
G	0005509	molecular_function	calcium ion binding
H	0005509	molecular_function	calcium ion binding
I	0006508	biological_process	proteolysis
I	0008236	molecular_function	serine-type peptidase activity
J	0006508	biological_process	proteolysis
J	0008236	molecular_function	serine-type peptidase activity
K	0006508	biological_process	proteolysis
K	0008236	molecular_function	serine-type peptidase activity
L	0006508	biological_process	proteolysis
L	0008236	molecular_function	serine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM

Chain	Residue	Details
E	ASP135-MET147
E	ASP183-PHE195
F	ASP135-MET147
F	ASP183-PHE195

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:17057713, ECO:0000269|PubMed:17187064

Chain	Residue	Details
E	ASP135
G	ASP135
G	ASN137
G	ASP139
G	TYR141
G	GLU146
G	ASP183
G	ASN185
G	ASP187
G	GLU194
E	ASN137
E	ASP139
E	TYR141
E	GLU146
E	ASP183
E	ASN185
E	ASP187
E	GLU194

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15476821

Chain	Residue	Details
J	ASN111
L	ASN473
L	ASN504
L	ASN751
C	GLU205-ALA228
C	THR280-SER286
C	TYR344-ILE357
C	PRO378-LYS384
J	ASN257
J	ASN342
J	ASN473
J	ASN504
J	ASN751
L	ASN111
L	ASN257
L	ASN342

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
J	ASN409
L	ASN409
D	PHE229-ALA250
C	PHE229-ALA250

---

site_id	SWS_FT_FI4
Number of Residues	96
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
B	ALA251-VAL261
B	SER307-ALA321
A	ALA251-VAL261
A	SER307-ALA321
D	ALA251-VAL261
D	SER307-ALA321
C	ALA251-VAL261
C	SER307-ALA321

---

site_id	SWS_FT_FI5
Number of Residues	68
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
B	MET262-MET279
A	MET262-MET279
D	MET262-MET279
C	MET262-MET279

---

site_id	SWS_FT_FI6
Number of Residues	76
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
B	GLY287-HIS306
A	GLY287-HIS306
D	GLY287-HIS306
C	GLY287-HIS306

---

site_id	SWS_FT_FI7
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
B	SER322-PHE343
A	SER322-PHE343
D	SER322-PHE343
C	SER322-PHE343

---

site_id	SWS_FT_FI8
Number of Residues	44
Details	INTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
B	PRO358-THR369
A	PRO358-THR369
D	PRO358-THR369
C	PRO358-THR369

---

site_id	SWS_FT_FI9
Number of Residues	28
Details	INTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
B	THR370-VAL377
A	THR370-VAL377
D	THR370-VAL377
C	THR370-VAL377

---

site_id	SWS_FT_FI10
Number of Residues	112
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
B	ILE385-TYR413
A	ILE385-TYR413
D	ILE385-TYR413
C	ILE385-TYR413

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q63881

Chain	Residue	Details
B	HIS105
C	HIS105
C	CYS132
C	CYS133
B	CYS132
B	CYS133
A	HIS105
A	CYS132
A	CYS133
D	HIS105
D	CYS132
D	CYS133

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63881

Chain	Residue	Details
B	THR38
A	THR38
D	THR38
C	THR38

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63881

Chain	Residue	Details
B	SER438
A	SER438
D	SER438
C	SER438

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