7E6E

Crystal structure of PMP-bound form of cysteine desulfurase SufS R376A from Bacillus subtilis in D-cycloserine-inhibition

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0006534	biological_process	cysteine metabolic process
A	0016740	molecular_function	transferase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0031071	molecular_function	cysteine desulfurase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue PMP A 501

Chain	Residue
A	ALA28
A	GLY274
A	THR275
A	HOH631
A	HOH639
A	THR92
A	THR93
A	HIS121
A	ASP198
A	ALA200
A	SER221
A	HIS223
A	LYS224

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PG4 A 502

Chain	Residue
A	HIS53
A	GLU252
A	LYS265
A	TRP269
A	HIS359

---

site_id	AC3
Number of Residues	4
Details	binding site for residue PEG A 503

Chain	Residue
A	GLU68
A	TRP269
A	ALA308
A	GLU312

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PEG A 504

Chain	Residue
A	VAL178
A	HIS304
A	ARG328

---

site_id	AC5
Number of Residues	2
Details	binding site for residue PEG A 505

Chain	Residue
A	HIS53
A	GLY55

---

site_id	AC6
Number of Residues	2
Details	binding site for residue PEG A 506

Chain	Residue
A	PRO11
A	ASN46

---

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO A 507

Chain	Residue
A	GLU72

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 508

Chain	Residue
A	ARG7
A	THR384
A	GLU386

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 511

Chain	Residue
A	THR40

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 512

Chain	Residue
A	ASN79
A	ARG313
A	GLN316

---

Functional Information from PROSITE/UniProt

site_id	PS00595
Number of Residues	20
Details	AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. CDFFalSSHKmcgpt.GvGvL

Chain	Residue	Details
A	CYS215-LEU234

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"PubMed","id":"27382962","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31587510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"31587510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5J8Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---