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7E51

Structure of PEP bound Enolase from Mycobacterium tuberculosis

Functional Information from GO Data
ChainGOidnamespacecontents
A0000015cellular_componentphosphopyruvate hydratase complex
A0000287molecular_functionmagnesium ion binding
A0004634molecular_functionphosphopyruvate hydratase activity
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006096biological_processglycolytic process
A0009274cellular_componentpeptidoglycan-based cell wall
A0009986cellular_componentcell surface
A0016829molecular_functionlyase activity
A0046872molecular_functionmetal ion binding
B0000015cellular_componentphosphopyruvate hydratase complex
B0000287molecular_functionmagnesium ion binding
B0004634molecular_functionphosphopyruvate hydratase activity
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006096biological_processglycolytic process
B0009274cellular_componentpeptidoglycan-based cell wall
B0009986cellular_componentcell surface
B0016829molecular_functionlyase activity
B0046872molecular_functionmetal ion binding
C0000015cellular_componentphosphopyruvate hydratase complex
C0000287molecular_functionmagnesium ion binding
C0004634molecular_functionphosphopyruvate hydratase activity
C0005576cellular_componentextracellular region
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006096biological_processglycolytic process
C0009274cellular_componentpeptidoglycan-based cell wall
C0009986cellular_componentcell surface
C0016829molecular_functionlyase activity
C0046872molecular_functionmetal ion binding
D0000015cellular_componentphosphopyruvate hydratase complex
D0000287molecular_functionmagnesium ion binding
D0004634molecular_functionphosphopyruvate hydratase activity
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006096biological_processglycolytic process
D0009274cellular_componentpeptidoglycan-based cell wall
D0009986cellular_componentcell surface
D0016829molecular_functionlyase activity
D0046872molecular_functionmetal ion binding
E0000015cellular_componentphosphopyruvate hydratase complex
E0000287molecular_functionmagnesium ion binding
E0004634molecular_functionphosphopyruvate hydratase activity
E0005576cellular_componentextracellular region
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0006096biological_processglycolytic process
E0009274cellular_componentpeptidoglycan-based cell wall
E0009986cellular_componentcell surface
E0016829molecular_functionlyase activity
E0046872molecular_functionmetal ion binding
F0000015cellular_componentphosphopyruvate hydratase complex
F0000287molecular_functionmagnesium ion binding
F0004634molecular_functionphosphopyruvate hydratase activity
F0005576cellular_componentextracellular region
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0006096biological_processglycolytic process
F0009274cellular_componentpeptidoglycan-based cell wall
F0009986cellular_componentcell surface
F0016829molecular_functionlyase activity
F0046872molecular_functionmetal ion binding
G0000015cellular_componentphosphopyruvate hydratase complex
G0000287molecular_functionmagnesium ion binding
G0004634molecular_functionphosphopyruvate hydratase activity
G0005576cellular_componentextracellular region
G0005737cellular_componentcytoplasm
G0005886cellular_componentplasma membrane
G0006096biological_processglycolytic process
G0009274cellular_componentpeptidoglycan-based cell wall
G0009986cellular_componentcell surface
G0016829molecular_functionlyase activity
G0046872molecular_functionmetal ion binding
H0000015cellular_componentphosphopyruvate hydratase complex
H0000287molecular_functionmagnesium ion binding
H0004634molecular_functionphosphopyruvate hydratase activity
H0005576cellular_componentextracellular region
H0005737cellular_componentcytoplasm
H0005886cellular_componentplasma membrane
H0006096biological_processglycolytic process
H0009274cellular_componentpeptidoglycan-based cell wall
H0009986cellular_componentcell surface
H0016829molecular_functionlyase activity
H0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00164
Number of Residues14
DetailsENOLASE Enolase signature. LLVKvNQIGTLTET
ChainResidueDetails
ALEU332-THR345

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00318
ChainResidueDetails
AGLU204
BGLU204
CGLU204
DGLU204
EGLU204
FGLU204
GGLU204
HGLU204

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00318
ChainResidueDetails
ALYS335
BLYS335
CLYS335
DLYS335
ELYS335
FLYS335
GLYS335
HLYS335

site_idSWS_FT_FI3
Number of Residues56
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00318
ChainResidueDetails
AHIS154
AGLU163
AASP241
AGLU283
AASP310
ASER362
ALYS386
BHIS154
BGLU163
BASP241
BGLU283
BASP310
BSER362
BLYS386
CHIS154
CGLU163
CASP241
CGLU283
CASP310
CSER362
CLYS386
DHIS154
DGLU163
DASP241
DGLU283
DASP310
DSER362
DLYS386
EHIS154
EGLU163
EASP241
EGLU283
EASP310
ESER362
ELYS386
FHIS154
FGLU163
FASP241
FGLU283
FASP310
FSER362
FLYS386
GHIS154
GGLU163
GASP241
GGLU283
GASP310
GSER362
GLYS386
HHIS154
HGLU163
HASP241
HGLU283
HASP310
HSER362
HLYS386

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: covalent; in inhibited form => ECO:0000255|HAMAP-Rule:MF_00318
ChainResidueDetails
ALYS335
BLYS335
CLYS335
DLYS335
ELYS335
FLYS335
GLYS335
HLYS335

219869

PDB entries from 2024-05-15

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