Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7E4W

Human Transcriptional Co-activator PC4 (C-terminal Domain) in space group P1211

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003713	molecular_function	transcription coactivator activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
B	0003677	molecular_function	DNA binding
B	0003713	molecular_function	transcription coactivator activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0003677	molecular_function	DNA binding
C	0003713	molecular_function	transcription coactivator activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0003677	molecular_function	DNA binding
D	0003713	molecular_function	transcription coactivator activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
E	0003677	molecular_function	DNA binding
E	0003713	molecular_function	transcription coactivator activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0003677	molecular_function	DNA binding
F	0003713	molecular_function	transcription coactivator activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0003677	molecular_function	DNA binding
G	0003713	molecular_function	transcription coactivator activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0003677	molecular_function	DNA binding
H	0003713	molecular_function	transcription coactivator activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0003677	molecular_function	DNA binding
I	0003713	molecular_function	transcription coactivator activity
I	0006355	biological_process	regulation of DNA-templated transcription
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0003677	molecular_function	DNA binding
J	0003713	molecular_function	transcription coactivator activity
J	0006355	biological_process	regulation of DNA-templated transcription
J	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
K	0003677	molecular_function	DNA binding
K	0003713	molecular_function	transcription coactivator activity
K	0006355	biological_process	regulation of DNA-templated transcription
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0003677	molecular_function	DNA binding
L	0003713	molecular_function	transcription coactivator activity
L	0006355	biological_process	regulation of DNA-templated transcription
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
M	0003677	molecular_function	DNA binding
M	0003713	molecular_function	transcription coactivator activity
M	0006355	biological_process	regulation of DNA-templated transcription
M	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0003677	molecular_function	DNA binding
N	0003713	molecular_function	transcription coactivator activity
N	0006355	biological_process	regulation of DNA-templated transcription
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0003677	molecular_function	DNA binding
O	0003713	molecular_function	transcription coactivator activity
O	0006355	biological_process	regulation of DNA-templated transcription
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0003677	molecular_function	DNA binding
P	0003713	molecular_function	transcription coactivator activity
P	0006355	biological_process	regulation of DNA-templated transcription
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS68
J	LYS68
K	LYS68
L	LYS68
M	LYS68
N	LYS68
O	LYS68
P	LYS68
B	LYS68
C	LYS68
D	LYS68
E	LYS68
F	LYS68
G	LYS68
H	LYS68
I	LYS68

site_id	SWS_FT_FI2
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER118
J	SER118
K	SER118
L	SER118
M	SER118
N	SER118
O	SER118
P	SER118
B	SER118
C	SER118
D	SER118
E	SER118
F	SER118
G	SER118
H	SER118
I	SER118

site_id	SWS_FT_FI3
Number of Residues	32
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS68
F	LYS68
G	LYS68
H	LYS68
I	LYS68
J	LYS68
K	LYS68
L	LYS68
M	LYS68
N	LYS68
O	LYS68
B	LYS68
P	LYS68
C	LYS68
D	LYS68
E	LYS68

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)