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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7DY2

Crystal Structure of Cyanobacterial Circadian Clock Protein KaiC

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0003677molecular_functionDNA binding
A0004674molecular_functionprotein serine/threonine kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0007623biological_processcircadian rhythm
A0009649biological_processentrainment of circadian clock
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0042752biological_processregulation of circadian rhythm
A0042754biological_processnegative regulation of circadian rhythm
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0048511biological_processrhythmic process
A0070297biological_processregulation of phosphorelay signal transduction system
A0106310molecular_functionprotein serine kinase activity
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0003677molecular_functionDNA binding
B0004674molecular_functionprotein serine/threonine kinase activity
B0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0006351biological_processDNA-templated transcription
B0006355biological_processregulation of DNA-templated transcription
B0007623biological_processcircadian rhythm
B0009649biological_processentrainment of circadian clock
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0042752biological_processregulation of circadian rhythm
B0042754biological_processnegative regulation of circadian rhythm
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0048511biological_processrhythmic process
B0070297biological_processregulation of phosphorelay signal transduction system
B0106310molecular_functionprotein serine kinase activity
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0003677molecular_functionDNA binding
C0004674molecular_functionprotein serine/threonine kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0006351biological_processDNA-templated transcription
C0006355biological_processregulation of DNA-templated transcription
C0007623biological_processcircadian rhythm
C0009649biological_processentrainment of circadian clock
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0042752biological_processregulation of circadian rhythm
C0042754biological_processnegative regulation of circadian rhythm
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0048511biological_processrhythmic process
C0070297biological_processregulation of phosphorelay signal transduction system
C0106310molecular_functionprotein serine kinase activity
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0003677molecular_functionDNA binding
D0004674molecular_functionprotein serine/threonine kinase activity
D0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0006351biological_processDNA-templated transcription
D0006355biological_processregulation of DNA-templated transcription
D0007623biological_processcircadian rhythm
D0009649biological_processentrainment of circadian clock
D0016301molecular_functionkinase activity
D0016740molecular_functiontransferase activity
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0042752biological_processregulation of circadian rhythm
D0042754biological_processnegative regulation of circadian rhythm
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0048511biological_processrhythmic process
D0070297biological_processregulation of phosphorelay signal transduction system
D0106310molecular_functionprotein serine kinase activity
E0000166molecular_functionnucleotide binding
E0000287molecular_functionmagnesium ion binding
E0003677molecular_functionDNA binding
E0004674molecular_functionprotein serine/threonine kinase activity
E0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0006351biological_processDNA-templated transcription
E0006355biological_processregulation of DNA-templated transcription
E0007623biological_processcircadian rhythm
E0009649biological_processentrainment of circadian clock
E0016301molecular_functionkinase activity
E0016740molecular_functiontransferase activity
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0042752biological_processregulation of circadian rhythm
E0042754biological_processnegative regulation of circadian rhythm
E0042802molecular_functionidentical protein binding
E0046872molecular_functionmetal ion binding
E0048511biological_processrhythmic process
E0070297biological_processregulation of phosphorelay signal transduction system
E0106310molecular_functionprotein serine kinase activity
F0000166molecular_functionnucleotide binding
F0000287molecular_functionmagnesium ion binding
F0003677molecular_functionDNA binding
F0004674molecular_functionprotein serine/threonine kinase activity
F0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0006351biological_processDNA-templated transcription
F0006355biological_processregulation of DNA-templated transcription
F0007623biological_processcircadian rhythm
F0009649biological_processentrainment of circadian clock
F0016301molecular_functionkinase activity
F0016740molecular_functiontransferase activity
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0042752biological_processregulation of circadian rhythm
F0042754biological_processnegative regulation of circadian rhythm
F0042802molecular_functionidentical protein binding
F0046872molecular_functionmetal ion binding
F0048511biological_processrhythmic process
F0070297biological_processregulation of phosphorelay signal transduction system
F0106310molecular_functionprotein serine kinase activity
G0000166molecular_functionnucleotide binding
G0000287molecular_functionmagnesium ion binding
G0003677molecular_functionDNA binding
G0004674molecular_functionprotein serine/threonine kinase activity
G0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0006351biological_processDNA-templated transcription
G0006355biological_processregulation of DNA-templated transcription
G0007623biological_processcircadian rhythm
G0009649biological_processentrainment of circadian clock
G0016301molecular_functionkinase activity
G0016740molecular_functiontransferase activity
G0016787molecular_functionhydrolase activity
G0016887molecular_functionATP hydrolysis activity
G0042752biological_processregulation of circadian rhythm
G0042754biological_processnegative regulation of circadian rhythm
G0042802molecular_functionidentical protein binding
G0046872molecular_functionmetal ion binding
G0048511biological_processrhythmic process
G0070297biological_processregulation of phosphorelay signal transduction system
G0106310molecular_functionprotein serine kinase activity
H0000166molecular_functionnucleotide binding
H0000287molecular_functionmagnesium ion binding
H0003677molecular_functionDNA binding
H0004674molecular_functionprotein serine/threonine kinase activity
H0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0006351biological_processDNA-templated transcription
H0006355biological_processregulation of DNA-templated transcription
H0007623biological_processcircadian rhythm
H0009649biological_processentrainment of circadian clock
H0016301molecular_functionkinase activity
H0016740molecular_functiontransferase activity
H0016787molecular_functionhydrolase activity
H0016887molecular_functionATP hydrolysis activity
H0042752biological_processregulation of circadian rhythm
H0042754biological_processnegative regulation of circadian rhythm
H0042802molecular_functionidentical protein binding
H0046872molecular_functionmetal ion binding
H0048511biological_processrhythmic process
H0070297biological_processregulation of phosphorelay signal transduction system
H0106310molecular_functionprotein serine kinase activity
I0000166molecular_functionnucleotide binding
I0000287molecular_functionmagnesium ion binding
I0003677molecular_functionDNA binding
I0004674molecular_functionprotein serine/threonine kinase activity
I0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0006351biological_processDNA-templated transcription
I0006355biological_processregulation of DNA-templated transcription
I0007623biological_processcircadian rhythm
I0009649biological_processentrainment of circadian clock
I0016301molecular_functionkinase activity
I0016740molecular_functiontransferase activity
I0016787molecular_functionhydrolase activity
I0016887molecular_functionATP hydrolysis activity
I0042752biological_processregulation of circadian rhythm
I0042754biological_processnegative regulation of circadian rhythm
I0042802molecular_functionidentical protein binding
I0046872molecular_functionmetal ion binding
I0048511biological_processrhythmic process
I0070297biological_processregulation of phosphorelay signal transduction system
I0106310molecular_functionprotein serine kinase activity
J0000166molecular_functionnucleotide binding
J0000287molecular_functionmagnesium ion binding
J0003677molecular_functionDNA binding
J0004674molecular_functionprotein serine/threonine kinase activity
J0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0006351biological_processDNA-templated transcription
J0006355biological_processregulation of DNA-templated transcription
J0007623biological_processcircadian rhythm
J0009649biological_processentrainment of circadian clock
J0016301molecular_functionkinase activity
J0016740molecular_functiontransferase activity
J0016787molecular_functionhydrolase activity
J0016887molecular_functionATP hydrolysis activity
J0042752biological_processregulation of circadian rhythm
J0042754biological_processnegative regulation of circadian rhythm
J0042802molecular_functionidentical protein binding
J0046872molecular_functionmetal ion binding
J0048511biological_processrhythmic process
J0070297biological_processregulation of phosphorelay signal transduction system
J0106310molecular_functionprotein serine kinase activity
K0000166molecular_functionnucleotide binding
K0000287molecular_functionmagnesium ion binding
K0003677molecular_functionDNA binding
K0004674molecular_functionprotein serine/threonine kinase activity
K0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0006351biological_processDNA-templated transcription
K0006355biological_processregulation of DNA-templated transcription
K0007623biological_processcircadian rhythm
K0009649biological_processentrainment of circadian clock
K0016301molecular_functionkinase activity
K0016740molecular_functiontransferase activity
K0016787molecular_functionhydrolase activity
K0016887molecular_functionATP hydrolysis activity
K0042752biological_processregulation of circadian rhythm
K0042754biological_processnegative regulation of circadian rhythm
K0042802molecular_functionidentical protein binding
K0046872molecular_functionmetal ion binding
K0048511biological_processrhythmic process
K0070297biological_processregulation of phosphorelay signal transduction system
K0106310molecular_functionprotein serine kinase activity
L0000166molecular_functionnucleotide binding
L0000287molecular_functionmagnesium ion binding
L0003677molecular_functionDNA binding
L0004674molecular_functionprotein serine/threonine kinase activity
L0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0006351biological_processDNA-templated transcription
L0006355biological_processregulation of DNA-templated transcription
L0007623biological_processcircadian rhythm
L0009649biological_processentrainment of circadian clock
L0016301molecular_functionkinase activity
L0016740molecular_functiontransferase activity
L0016787molecular_functionhydrolase activity
L0016887molecular_functionATP hydrolysis activity
L0042752biological_processregulation of circadian rhythm
L0042754biological_processnegative regulation of circadian rhythm
L0042802molecular_functionidentical protein binding
L0046872molecular_functionmetal ion binding
L0048511biological_processrhythmic process
L0070297biological_processregulation of phosphorelay signal transduction system
L0106310molecular_functionprotein serine kinase activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsActive site: {"description":"Proton acceptor in CI (KaiC 1)","evidences":[{"source":"PubMed","id":"22304631","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsActive site: {"description":"Proton acceptor in CII (KaiC 2)","evidences":[{"source":"PubMed","id":"22304631","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues300
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01836","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15304218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16628225","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22304631","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DUG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01836","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"4DUG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DXQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01836","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15304218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16628225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GBL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01836","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15304218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16628225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1U9I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DUG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DXQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01836","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15304218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16628225","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"HAMAP-Rule","id":"MF_01836","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15347809","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15347812","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17717528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17916691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1U9I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GBL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"HAMAP-Rule","id":"MF_01836","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15304218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15347809","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15347812","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17717528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17916691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1U9I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GBL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues9
DetailsRegion: {"description":"A-loop, interacts with KaiA","evidences":[{"source":"PubMed","id":"18728181","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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