7DY2

Crystal Structure of Cyanobacterial Circadian Clock Protein KaiC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007623	biological_process	circadian rhythm
A	0009649	biological_process	entrainment of circadian clock
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0042752	biological_process	regulation of circadian rhythm
A	0042754	biological_process	negative regulation of circadian rhythm
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0048511	biological_process	rhythmic process
A	0070297	biological_process	regulation of phosphorelay signal transduction system
A	0106310	molecular_function	protein serine kinase activity
B	0000287	molecular_function	magnesium ion binding
B	0003677	molecular_function	DNA binding
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006355	biological_process	regulation of DNA-templated transcription
B	0007623	biological_process	circadian rhythm
B	0009649	biological_process	entrainment of circadian clock
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0042752	biological_process	regulation of circadian rhythm
B	0042754	biological_process	negative regulation of circadian rhythm
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0048511	biological_process	rhythmic process
B	0070297	biological_process	regulation of phosphorelay signal transduction system
B	0106310	molecular_function	protein serine kinase activity
C	0000287	molecular_function	magnesium ion binding
C	0003677	molecular_function	DNA binding
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006355	biological_process	regulation of DNA-templated transcription
C	0007623	biological_process	circadian rhythm
C	0009649	biological_process	entrainment of circadian clock
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0042752	biological_process	regulation of circadian rhythm
C	0042754	biological_process	negative regulation of circadian rhythm
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0048511	biological_process	rhythmic process
C	0070297	biological_process	regulation of phosphorelay signal transduction system
C	0106310	molecular_function	protein serine kinase activity
D	0000287	molecular_function	magnesium ion binding
D	0003677	molecular_function	DNA binding
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006355	biological_process	regulation of DNA-templated transcription
D	0007623	biological_process	circadian rhythm
D	0009649	biological_process	entrainment of circadian clock
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0042752	biological_process	regulation of circadian rhythm
D	0042754	biological_process	negative regulation of circadian rhythm
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0048511	biological_process	rhythmic process
D	0070297	biological_process	regulation of phosphorelay signal transduction system
D	0106310	molecular_function	protein serine kinase activity
E	0000287	molecular_function	magnesium ion binding
E	0003677	molecular_function	DNA binding
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006355	biological_process	regulation of DNA-templated transcription
E	0007623	biological_process	circadian rhythm
E	0009649	biological_process	entrainment of circadian clock
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0042752	biological_process	regulation of circadian rhythm
E	0042754	biological_process	negative regulation of circadian rhythm
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0048511	biological_process	rhythmic process
E	0070297	biological_process	regulation of phosphorelay signal transduction system
E	0106310	molecular_function	protein serine kinase activity
F	0000287	molecular_function	magnesium ion binding
F	0003677	molecular_function	DNA binding
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0006355	biological_process	regulation of DNA-templated transcription
F	0007623	biological_process	circadian rhythm
F	0009649	biological_process	entrainment of circadian clock
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0042752	biological_process	regulation of circadian rhythm
F	0042754	biological_process	negative regulation of circadian rhythm
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0048511	biological_process	rhythmic process
F	0070297	biological_process	regulation of phosphorelay signal transduction system
F	0106310	molecular_function	protein serine kinase activity
G	0000287	molecular_function	magnesium ion binding
G	0003677	molecular_function	DNA binding
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0006355	biological_process	regulation of DNA-templated transcription
G	0007623	biological_process	circadian rhythm
G	0009649	biological_process	entrainment of circadian clock
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0042752	biological_process	regulation of circadian rhythm
G	0042754	biological_process	negative regulation of circadian rhythm
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0048511	biological_process	rhythmic process
G	0070297	biological_process	regulation of phosphorelay signal transduction system
G	0106310	molecular_function	protein serine kinase activity
H	0000287	molecular_function	magnesium ion binding
H	0003677	molecular_function	DNA binding
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0006355	biological_process	regulation of DNA-templated transcription
H	0007623	biological_process	circadian rhythm
H	0009649	biological_process	entrainment of circadian clock
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0042752	biological_process	regulation of circadian rhythm
H	0042754	biological_process	negative regulation of circadian rhythm
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
H	0048511	biological_process	rhythmic process
H	0070297	biological_process	regulation of phosphorelay signal transduction system
H	0106310	molecular_function	protein serine kinase activity
I	0000287	molecular_function	magnesium ion binding
I	0003677	molecular_function	DNA binding
I	0004674	molecular_function	protein serine/threonine kinase activity
I	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0006355	biological_process	regulation of DNA-templated transcription
I	0007623	biological_process	circadian rhythm
I	0009649	biological_process	entrainment of circadian clock
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0042752	biological_process	regulation of circadian rhythm
I	0042754	biological_process	negative regulation of circadian rhythm
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
I	0048511	biological_process	rhythmic process
I	0070297	biological_process	regulation of phosphorelay signal transduction system
I	0106310	molecular_function	protein serine kinase activity
J	0000287	molecular_function	magnesium ion binding
J	0003677	molecular_function	DNA binding
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0006355	biological_process	regulation of DNA-templated transcription
J	0007623	biological_process	circadian rhythm
J	0009649	biological_process	entrainment of circadian clock
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0042752	biological_process	regulation of circadian rhythm
J	0042754	biological_process	negative regulation of circadian rhythm
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
J	0048511	biological_process	rhythmic process
J	0070297	biological_process	regulation of phosphorelay signal transduction system
J	0106310	molecular_function	protein serine kinase activity
K	0000287	molecular_function	magnesium ion binding
K	0003677	molecular_function	DNA binding
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0006355	biological_process	regulation of DNA-templated transcription
K	0007623	biological_process	circadian rhythm
K	0009649	biological_process	entrainment of circadian clock
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0042752	biological_process	regulation of circadian rhythm
K	0042754	biological_process	negative regulation of circadian rhythm
K	0042802	molecular_function	identical protein binding
K	0046872	molecular_function	metal ion binding
K	0048511	biological_process	rhythmic process
K	0070297	biological_process	regulation of phosphorelay signal transduction system
K	0106310	molecular_function	protein serine kinase activity
L	0000287	molecular_function	magnesium ion binding
L	0003677	molecular_function	DNA binding
L	0004674	molecular_function	protein serine/threonine kinase activity
L	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0006355	biological_process	regulation of DNA-templated transcription
L	0007623	biological_process	circadian rhythm
L	0009649	biological_process	entrainment of circadian clock
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0042752	biological_process	regulation of circadian rhythm
L	0042754	biological_process	negative regulation of circadian rhythm
L	0042802	molecular_function	identical protein binding
L	0046872	molecular_function	metal ion binding
L	0048511	biological_process	rhythmic process
L	0070297	biological_process	regulation of phosphorelay signal transduction system
L	0106310	molecular_function	protein serine kinase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor in CI (KaiC 1) => ECO:0000305|PubMed:22304631

Chain	Residue	Details
B	GLU77
E	GLU77
F	GLU77
C	GLU77
D	GLU77
G	GLU77
K	GLU77
I	GLU77
J	GLU77
H	GLU77
L	GLU77

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor in CII (KaiC 2) => ECO:0000305|PubMed:22304631

Chain	Residue	Details
H	GLU318
D	GLU318
G	GLU318
K	GLU318
L	GLU318
I	GLU318
J	GLU318
B	GLU318
E	GLU318
F	GLU318
C	GLU318

---

site_id	SWS_FT_FI3
Number of Residues	25
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:16628225, ECO:0000269|PubMed:22304631, ECO:0007744|PDB:1TF7, ECO:0007744|PDB:2GBL, ECO:0007744|PDB:4DUG

Chain	Residue	Details
H	GLY49
H	THR50
H	GLY51
H	LYS52
H	LEU54
H	SER89
H	LYS224
H	ARG226
H	THR228
H	HIS230
H	THR240
H	ASP241
H	THR290
H	GLY291
H	THR292
H	GLY293
H	LYS294
H	LEU296
H	TRP331
H	ARG451
H	LYS457
H	ARG459
H	SER461
H	HIS463
H	LYS465
B	GLY49
B	THR50
B	GLY51
B	LYS52
B	LEU54
B	SER89
B	LYS224
B	ARG226
B	THR228
B	HIS230
B	THR240
B	ASP241
B	THR290
B	GLY291
B	THR292
B	GLY293
B	LYS294
B	LEU296
B	TRP331
B	ARG451
B	LYS457
B	ARG459
B	SER461
B	HIS463
B	LYS465
E	GLY49
E	THR50
E	GLY51
E	LYS52
E	LEU54
E	SER89
E	LYS224
E	ARG226
E	THR228
E	HIS230
E	THR240
E	ASP241
E	THR290
E	GLY291
E	THR292
E	GLY293
E	LYS294
E	LEU296
E	TRP331
E	ARG451
E	LYS457
E	ARG459
E	SER461
E	HIS463
E	LYS465
F	GLY49
F	THR50
F	GLY51
F	LYS52
F	LEU54
F	SER89
F	LYS224
F	ARG226
F	THR228
F	HIS230
F	THR240
F	ASP241
F	THR290
F	GLY291
F	THR292
F	GLY293
F	LYS294
F	LEU296
F	TRP331
F	ARG451
F	LYS457
F	ARG459
F	SER461
F	HIS463
F	LYS465
C	GLY49
C	THR50
C	GLY51
C	LYS52
C	LEU54
C	SER89
C	LYS224
C	ARG226
C	THR228
C	HIS230
C	THR240
C	ASP241
C	THR290
C	GLY291
C	THR292
C	GLY293
C	LYS294
C	LEU296
C	TRP331
C	ARG451
C	LYS457
C	ARG459
C	SER461
C	HIS463
C	LYS465
D	GLY49
D	THR50
D	GLY51
D	LYS52
D	LEU54
D	SER89
D	LYS224
D	ARG226
D	THR228
D	HIS230
D	THR240
D	ASP241
D	THR290
D	GLY291
D	THR292
D	GLY293
D	LYS294
D	LEU296
D	TRP331
D	ARG451
D	LYS457
D	ARG459
D	SER461
D	HIS463
D	LYS465
G	GLY49
G	THR50
G	GLY51
G	LYS52
G	LEU54
G	SER89
G	LYS224
G	ARG226
G	THR228
G	HIS230
G	THR240
G	ASP241
G	THR290
G	GLY291
G	THR292
G	GLY293
G	LYS294
G	LEU296
G	TRP331
G	ARG451
G	LYS457
G	ARG459
G	SER461
G	HIS463
G	LYS465
K	GLY49
K	THR50
K	GLY51
K	LYS52
K	LEU54
K	SER89
K	LYS224
K	ARG226
K	THR228
K	HIS230
K	THR240
K	ASP241
K	THR290
K	GLY291
K	THR292
K	GLY293
K	LYS294
K	LEU296
K	TRP331
K	ARG451
K	LYS457
K	ARG459
K	SER461
K	HIS463
K	LYS465
L	GLY49
L	THR50
L	GLY51
L	LYS52
L	LEU54
L	SER89
L	LYS224
L	ARG226
L	THR228
L	HIS230
L	THR240
L	ASP241
L	THR290
L	GLY291
L	THR292
L	GLY293
L	LYS294
L	LEU296
L	TRP331
L	ARG451
L	LYS457
L	ARG459
L	SER461
L	HIS463
L	LYS465
I	GLY49
I	THR50
I	GLY51
I	LYS52
I	LEU54
I	SER89
I	LYS224
I	ARG226
I	THR228
I	HIS230
I	THR240
I	ASP241
I	THR290
I	GLY291
I	THR292
I	GLY293
I	LYS294
I	LEU296
I	TRP331
I	ARG451
I	LYS457
I	ARG459
I	SER461
I	HIS463
I	LYS465
J	GLY49
J	THR50
J	GLY51
J	LYS52
J	LEU54
J	SER89
J	LYS224
J	ARG226
J	THR228
J	HIS230
J	THR240
J	ASP241
J	THR290
J	GLY291
J	THR292
J	GLY293
J	LYS294
J	LEU296
J	TRP331
J	ARG451
J	LYS457
J	ARG459
J	SER461
J	HIS463
J	LYS465

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0007744|PDB:4DUG, ECO:0007744|PDB:4TL6, ECO:0007744|PDB:7DXQ

Chain	Residue	Details
H	THR53
B	THR53
E	THR53
F	THR53
C	THR53
D	THR53
G	THR53
K	THR53
L	THR53
I	THR53
J	THR53

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:16628225, ECO:0007744|PDB:1TF7, ECO:0007744|PDB:2GBL

Chain	Residue	Details
H	LEU225
H	MET458
B	LEU225
B	MET458
E	LEU225
E	MET458
F	LEU225
F	MET458
C	LEU225
C	MET458
D	LEU225
D	MET458
G	LEU225
G	MET458
K	LEU225
K	MET458
L	LEU225
L	MET458
I	LEU225
I	MET458
J	LEU225
J	MET458

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:16628225, ECO:0007744|PDB:1U9I, ECO:0007744|PDB:2GBL, ECO:0007744|PDB:4DUG, ECO:0007744|PDB:7DXQ

Chain	Residue	Details
H	THR295
B	THR295
E	THR295
F	THR295
C	THR295
D	THR295
G	THR295
K	THR295
L	THR295
I	THR295
J	THR295

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:16628225

Chain	Residue	Details
H	GLU318
B	GLU318
E	GLU318
F	GLU318
C	GLU318
D	GLU318
G	GLU318
K	GLU318
L	GLU318
I	GLU318
J	GLU318

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15347809, ECO:0000269|PubMed:15347812, ECO:0000269|PubMed:17717528, ECO:0000269|PubMed:17916691, ECO:0007744|PDB:1U9I, ECO:0007744|PDB:2GBL

Chain	Residue	Details
H	SER431
B	SEP431
E	SEP431
F	SEP431
C	SEP431
D	SEP431
G	SEP431
K	SEP431
L	SEP431
I	SEP431
J	SEP431

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:15347809, ECO:0000269|PubMed:15347812, ECO:0000269|PubMed:17717528, ECO:0000269|PubMed:17916691, ECO:0007744|PDB:1U9I, ECO:0007744|PDB:2GBL

Chain	Residue	Details
H	THR432
B	THR432
E	THR432
F	THR432
C	THR432
D	THR432
G	THR432
K	THR432
L	THR432
I	THR432
J	THR432

---