7DY1

Crystal Structure of Cyanobacterial Circadian Clock Protein KaiC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007623	biological_process	circadian rhythm
A	0016301	molecular_function	kinase activity
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0042752	biological_process	regulation of circadian rhythm
A	0042802	molecular_function	identical protein binding
A	0046777	biological_process	protein autophosphorylation
A	0046872	molecular_function	metal ion binding
A	0048511	biological_process	rhythmic process
A	0106310	molecular_function	protein serine kinase activity
B	0000287	molecular_function	magnesium ion binding
B	0003677	molecular_function	DNA binding
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006355	biological_process	regulation of DNA-templated transcription
B	0007623	biological_process	circadian rhythm
B	0016301	molecular_function	kinase activity
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0042752	biological_process	regulation of circadian rhythm
B	0042802	molecular_function	identical protein binding
B	0046777	biological_process	protein autophosphorylation
B	0046872	molecular_function	metal ion binding
B	0048511	biological_process	rhythmic process
B	0106310	molecular_function	protein serine kinase activity
C	0000287	molecular_function	magnesium ion binding
C	0003677	molecular_function	DNA binding
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006355	biological_process	regulation of DNA-templated transcription
C	0007623	biological_process	circadian rhythm
C	0016301	molecular_function	kinase activity
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0042752	biological_process	regulation of circadian rhythm
C	0042802	molecular_function	identical protein binding
C	0046777	biological_process	protein autophosphorylation
C	0046872	molecular_function	metal ion binding
C	0048511	biological_process	rhythmic process
C	0106310	molecular_function	protein serine kinase activity
D	0000287	molecular_function	magnesium ion binding
D	0003677	molecular_function	DNA binding
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006355	biological_process	regulation of DNA-templated transcription
D	0007623	biological_process	circadian rhythm
D	0016301	molecular_function	kinase activity
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0042752	biological_process	regulation of circadian rhythm
D	0042802	molecular_function	identical protein binding
D	0046777	biological_process	protein autophosphorylation
D	0046872	molecular_function	metal ion binding
D	0048511	biological_process	rhythmic process
D	0106310	molecular_function	protein serine kinase activity
E	0000287	molecular_function	magnesium ion binding
E	0003677	molecular_function	DNA binding
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006355	biological_process	regulation of DNA-templated transcription
E	0007623	biological_process	circadian rhythm
E	0016301	molecular_function	kinase activity
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0042752	biological_process	regulation of circadian rhythm
E	0042802	molecular_function	identical protein binding
E	0046777	biological_process	protein autophosphorylation
E	0046872	molecular_function	metal ion binding
E	0048511	biological_process	rhythmic process
E	0106310	molecular_function	protein serine kinase activity
F	0000287	molecular_function	magnesium ion binding
F	0003677	molecular_function	DNA binding
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0006355	biological_process	regulation of DNA-templated transcription
F	0007623	biological_process	circadian rhythm
F	0016301	molecular_function	kinase activity
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0042752	biological_process	regulation of circadian rhythm
F	0042802	molecular_function	identical protein binding
F	0046777	biological_process	protein autophosphorylation
F	0046872	molecular_function	metal ion binding
F	0048511	biological_process	rhythmic process
F	0106310	molecular_function	protein serine kinase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Proton acceptor in CI (KaiC 1) => ECO:0000305|PubMed:35507871

Chain	Residue	Details
B	GLU78
C	GLU78
D	GLU78
E	GLU78
F	GLU78

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	ACT_SITE: Proton acceptor in CII (KaiC 2) => ECO:0000305|PubMed:35507871

Chain	Residue	Details
B	GLU318
C	GLU318
D	GLU318
E	GLU318
F	GLU318

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000312|PDB:7DY1

Chain	Residue	Details
B	SER49
C	SER49
D	SER49
E	SER49
F	SER49

---

site_id	SWS_FT_FI4
Number of Residues	105
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000312|PDB:7DY1

Chain	Residue	Details
B	GLY50
B	HIS231
F	THR295
F	LEU296
F	ARG451
F	LYS457
F	MET458
F	ARG459
B	THR290
B	GLY291
B	THR292
B	GLY293
B	LYS294
B	THR295
B	LEU296
B	ARG451
B	LYS457
B	THR51
B	MET458
B	ARG459
C	GLY50
C	THR51
C	GLY52
C	LYS53
C	LEU55
C	SER90
C	LYS225
C	LEU226
B	GLY52
C	ARG227
C	HIS231
C	THR290
C	GLY291
C	THR292
C	GLY293
C	LYS294
C	THR295
C	LEU296
C	ARG451
B	LYS53
C	LYS457
C	MET458
C	ARG459
D	GLY50
D	THR51
D	GLY52
D	LYS53
D	LEU55
D	SER90
D	LYS225
B	LEU55
D	LEU226
D	ARG227
D	HIS231
D	THR290
D	GLY291
D	THR292
D	GLY293
D	LYS294
D	THR295
D	LEU296
B	SER90
D	ARG451
D	LYS457
D	MET458
D	ARG459
E	GLY50
E	THR51
E	GLY52
E	LYS53
E	LEU55
E	SER90
B	LYS225
E	LYS225
E	LEU226
E	ARG227
E	HIS231
E	THR290
E	GLY291
E	THR292
E	GLY293
E	LYS294
E	THR295
B	LEU226
E	LEU296
E	ARG451
E	LYS457
E	MET458
E	ARG459
F	GLY50
F	THR51
F	GLY52
F	LYS53
F	LEU55
B	ARG227
F	SER90
F	LYS225
F	LEU226
F	ARG227
F	HIS231
F	THR290
F	GLY291
F	THR292
F	GLY293
F	LYS294

---

site_id	SWS_FT_FI5
Number of Residues	35
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836

Chain	Residue	Details
B	THR54
C	GLU318
C	TRP331
C	SER461
C	HIS463
C	LYS465
D	THR54
D	THR229
D	GLU318
D	TRP331
D	SER461
B	THR229
D	HIS463
D	LYS465
E	THR54
E	THR229
E	GLU318
E	TRP331
E	SER461
E	HIS463
E	LYS465
F	THR54
B	GLU318
F	THR229
F	GLU318
F	TRP331
F	SER461
F	HIS463
F	LYS465
B	TRP331
B	SER461
B	HIS463
B	LYS465
C	THR54
C	THR229

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:24112939

Chain	Residue	Details
B	SEP431
C	SEP431
D	SEP431
E	SEP431
F	SEP431

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:24112939

Chain	Residue	Details
B	TPO432
C	TPO432
D	TPO432
E	TPO432
F	TPO432

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