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7DXJ

Human 46QHuntingtin-HAP40 complex structure

Functional Information from GO Data
ChainGOidnamespacecontents
A0000132biological_processestablishment of mitotic spindle orientation
A0002039molecular_functionp53 binding
A0004721molecular_functionphosphoprotein phosphatase activity
A0005515molecular_functionprotein binding
A0005522molecular_functionprofilin binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005776cellular_componentautophagosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005814cellular_componentcentriole
A0005829cellular_componentcytosol
A0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
A0006915biological_processapoptotic process
A0007030biological_processGolgi organization
A0016234cellular_componentinclusion body
A0019900molecular_functionkinase binding
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030659cellular_componentcytoplasmic vesicle membrane
A0031072molecular_functionheat shock protein binding
A0031587biological_processpositive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
A0031648biological_processprotein destabilization
A0032991cellular_componentprotein-containing complex
A0034452molecular_functiondynactin binding
A0042297biological_processvocal learning
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0044325molecular_functiontransmembrane transporter binding
A0045505molecular_functiondynein intermediate chain binding
A0045724biological_processpositive regulation of cilium assembly
A0047496biological_processvesicle transport along microtubule
A0048471cellular_componentperinuclear region of cytoplasm
A0048487molecular_functionbeta-tubulin binding
A0099111biological_processmicrotubule-based transport
A0099523cellular_componentpresynaptic cytosol
A0099524cellular_componentpostsynaptic cytosol
A1901526biological_processpositive regulation of mitophagy
A1904504biological_processpositive regulation of lipophagy
A1905289biological_processregulation of CAMKK-AMPK signaling cascade
A1905337biological_processpositive regulation of aggrephagy
A2000479biological_processregulation of cAMP-dependent protein kinase activity
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0016604cellular_componentnuclear body
B0099518biological_processvesicle cytoskeletal trafficking
B1901799biological_processnegative regulation of proteasomal protein catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
BALA2

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by caspase-3 => ECO:0000255
ChainResidueDetails
AASP524
AASP583

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:29802276
ChainResidueDetails
AASP546

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Cleavage; by caspase-6 => ECO:0000269|PubMed:10770929
ChainResidueDetails
AASP580

site_idSWS_FT_FI5
Number of Residues5
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21685499
ChainResidueDetails
ALYS-20
ALYS172
ALYS230
ALYS339
ALYS438

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER407

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P42859
ChainResidueDetails
ASER413
ASER415

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER428

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER636
ASER639

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5 => ECO:0000269|PubMed:17611284
ChainResidueDetails
ASER1175

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5 => ECO:0000269|PubMed:17611284, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1195

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER1866

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1870

site_idSWS_FT_FI14
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:24459296, ECO:0000269|PubMed:29802276
ChainResidueDetails
AGLY547

226707

PDB entries from 2024-10-30

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