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7DXJ

Human 46QHuntingtin-HAP40 complex structure

Functional Information from GO Data
ChainGOidnamespacecontents
A0000132biological_processestablishment of mitotic spindle orientation
A0002039molecular_functionp53 binding
A0004721molecular_functionphosphoprotein phosphatase activity
A0005515molecular_functionprotein binding
A0005522molecular_functionprofilin binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005776cellular_componentautophagosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005814cellular_componentcentriole
A0005829cellular_componentcytosol
A0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
A0006915biological_processapoptotic process
A0007017biological_processmicrotubule-based process
A0007030biological_processGolgi organization
A0007417biological_processcentral nervous system development
A0009966biological_processregulation of signal transduction
A0016234cellular_componentinclusion body
A0019900molecular_functionkinase binding
A0022008biological_processneurogenesis
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030659cellular_componentcytoplasmic vesicle membrane
A0031072molecular_functionheat shock protein binding
A0031410cellular_componentcytoplasmic vesicle
A0031587biological_processpositive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
A0031648biological_processprotein destabilization
A0032991cellular_componentprotein-containing complex
A0034452molecular_functiondynactin binding
A0042297biological_processvocal learning
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0044325molecular_functiontransmembrane transporter binding
A0045202cellular_componentsynapse
A0045505molecular_functiondynein intermediate chain binding
A0045724biological_processpositive regulation of cilium assembly
A0047496biological_processvesicle transport along microtubule
A0048471cellular_componentperinuclear region of cytoplasm
A0048487molecular_functionbeta-tubulin binding
A0048489biological_processsynaptic vesicle transport
A0099523cellular_componentpresynaptic cytosol
A0099524cellular_componentpostsynaptic cytosol
A1901526biological_processpositive regulation of mitophagy
A1904504biological_processpositive regulation of lipophagy
A1905289biological_processregulation of CAMKK-AMPK signaling cascade
A1905291biological_processpositive regulation of CAMKK-AMPK signaling cascade
A1905337biological_processpositive regulation of aggrephagy
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0016604cellular_componentnuclear body
B0099518biological_processvesicle cytoskeletal trafficking
B1901799biological_processnegative regulation of proteasomal protein catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues37
DetailsRepeat: {"description":"HEAT 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues37
DetailsRepeat: {"description":"HEAT 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues37
DetailsRepeat: {"description":"HEAT 4"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues38
DetailsRepeat: {"description":"HEAT 5"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues9
DetailsMotif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21685499","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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