7DMQ
Cryo-EM structure of LshCas13a-crRNA-anti-tag RNA complex
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00268 |
| Number of Residues | 9 |
| Details | CECROPIN Cecropin family signature. W..NITKRIEK |
| Chain | Residue | Details |
| A | TRP305-LYS313 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 150 |
| Details | Region: {"description":"Helical-1","evidences":[{"source":"PubMed","id":"26593719","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27256883","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28086085","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 29 |
| Details | Region: {"description":"Binds crRNA","evidences":[{"source":"PubMed","id":"28086085","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 137 |
| Details | Region: {"description":"HEPN-like fold 1-I","evidences":[{"source":"PubMed","id":"26593719","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27256883","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28086085","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 120 |
| Details | Region: {"description":"HEPN-like fold 2","evidences":[{"source":"PubMed","id":"26593719","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27256883","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28086085","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 30 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For pre-crRNA processing","evidences":[{"source":"PubMed","id":"28086085","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For target ssRNA cleavage","evidences":[{"source":"PubMed","id":"27256883","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28086085","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
