7DFP
Human dopamine D2 receptor in complex with spiperone
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| B | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32528175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33571431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37221270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40683247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 9 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39103320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"40781549","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by GRK2 and GRK3","evidences":[{"source":"PubMed","id":"33859231","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40781549","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by GRK2 and GRK3","evidences":[{"source":"PubMed","id":"33859231","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by GRK2 and GRK3","evidences":[{"source":"PubMed","id":"33859231","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P61169","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P61169","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
