7DFC

Crystal of Arrestin2-V2Rpp-3-Fab30 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000822	molecular_function	inositol hexakisphosphate binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
A	0002031	biological_process	G protein-coupled receptor internalization
A	0002092	biological_process	positive regulation of receptor internalization
A	0005515	molecular_function	protein binding
A	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005905	cellular_component	clathrin-coated pit
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006898	biological_process	receptor-mediated endocytosis
A	0007165	biological_process	signal transduction
A	0007600	biological_process	sensory perception
A	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
A	0009968	biological_process	negative regulation of signal transduction
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0030132	cellular_component	clathrin coat of coated pit
A	0030276	molecular_function	clathrin binding
A	0031143	cellular_component	pseudopodium
A	0031410	cellular_component	cytoplasmic vesicle
A	0031623	biological_process	receptor internalization
A	0032050	molecular_function	clathrin heavy chain binding
A	0033130	molecular_function	acetylcholine receptor binding
A	0035612	molecular_function	AP-2 adaptor complex binding
A	0036094	molecular_function	small molecule binding
A	0042995	cellular_component	cell projection
A	0045746	biological_process	negative regulation of Notch signaling pathway
A	0060090	molecular_function	molecular adaptor activity
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0072583	biological_process	clathrin-dependent endocytosis

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR205-HIS211
H	TYR216-HIS222

---

site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL

Chain	Residue	Details
A	PHE61-LEU79

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Region: {"description":"Interaction with CHRM2"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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