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7DDK

Crystal structures of Na+,K+-ATPase in complex with rostafuroxin

Replaces:  6KQ0
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002028biological_processregulation of sodium ion transport
A0005215molecular_functiontransporter activity
A0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0005890cellular_componentsodium:potassium-exchanging ATPase complex
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0006883biological_processintracellular sodium ion homeostasis
A0008556molecular_functionP-type potassium transmembrane transporter activity
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0030007biological_processintracellular potassium ion homeostasis
A0030424cellular_componentaxon
A0030955molecular_functionpotassium ion binding
A0031402molecular_functionsodium ion binding
A0036376biological_processsodium ion export across plasma membrane
A0042383cellular_componentsarcolemma
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0046872molecular_functionmetal ion binding
A0051117molecular_functionATPase binding
A0055085biological_processtransmembrane transport
A0086009biological_processmembrane repolarization
A1902600biological_processproton transmembrane transport
A1990573biological_processpotassium ion import across plasma membrane
B0001671molecular_functionATPase activator activity
B0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005890cellular_componentsodium:potassium-exchanging ATPase complex
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006883biological_processintracellular sodium ion homeostasis
B0007155biological_processcell adhesion
B0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
B0016324cellular_componentapical plasma membrane
B0030007biological_processintracellular potassium ion homeostasis
B0030674molecular_functionprotein-macromolecule adaptor activity
B0036376biological_processsodium ion export across plasma membrane
B0042383cellular_componentsarcolemma
B0045087biological_processinnate immune response
B0051117molecular_functionATPase binding
B0055085biological_processtransmembrane transport
B0086009biological_processmembrane repolarization
B1902600biological_processproton transmembrane transport
B1903278biological_processpositive regulation of sodium ion export across plasma membrane
B1903288biological_processpositive regulation of potassium ion import across plasma membrane
B1903408biological_processpositive regulation of P-type sodium:potassium-exchanging transporter activity
B1990573biological_processpotassium ion import across plasma membrane
C0000166molecular_functionnucleotide binding
C0002028biological_processregulation of sodium ion transport
C0005215molecular_functiontransporter activity
C0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0005890cellular_componentsodium:potassium-exchanging ATPase complex
C0006813biological_processpotassium ion transport
C0006814biological_processsodium ion transport
C0006883biological_processintracellular sodium ion homeostasis
C0008556molecular_functionP-type potassium transmembrane transporter activity
C0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016887molecular_functionATP hydrolysis activity
C0030007biological_processintracellular potassium ion homeostasis
C0030424cellular_componentaxon
C0030955molecular_functionpotassium ion binding
C0031402molecular_functionsodium ion binding
C0036376biological_processsodium ion export across plasma membrane
C0042383cellular_componentsarcolemma
C0042470cellular_componentmelanosome
C0042995cellular_componentcell projection
C0046872molecular_functionmetal ion binding
C0051117molecular_functionATPase binding
C0055085biological_processtransmembrane transport
C0086009biological_processmembrane repolarization
C1902600biological_processproton transmembrane transport
C1990573biological_processpotassium ion import across plasma membrane
D0001671molecular_functionATPase activator activity
D0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005890cellular_componentsodium:potassium-exchanging ATPase complex
D0006813biological_processpotassium ion transport
D0006814biological_processsodium ion transport
D0006883biological_processintracellular sodium ion homeostasis
D0007155biological_processcell adhesion
D0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
D0016324cellular_componentapical plasma membrane
D0030007biological_processintracellular potassium ion homeostasis
D0030674molecular_functionprotein-macromolecule adaptor activity
D0036376biological_processsodium ion export across plasma membrane
D0042383cellular_componentsarcolemma
D0045087biological_processinnate immune response
D0051117molecular_functionATPase binding
D0055085biological_processtransmembrane transport
D0086009biological_processmembrane repolarization
D1902600biological_processproton transmembrane transport
D1903278biological_processpositive regulation of sodium ion export across plasma membrane
D1903288biological_processpositive regulation of potassium ion import across plasma membrane
D1903408biological_processpositive regulation of P-type sodium:potassium-exchanging transporter activity
D1990573biological_processpotassium ion import across plasma membrane
E0001671molecular_functionATPase activator activity
E0005515molecular_functionprotein binding
E0005890cellular_componentsodium:potassium-exchanging ATPase complex
E0006811biological_processmonoatomic ion transport
E0006883biological_processintracellular sodium ion homeostasis
E0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
E0016020cellular_componentmembrane
E0030007biological_processintracellular potassium ion homeostasis
E0030674molecular_functionprotein-macromolecule adaptor activity
E0036376biological_processsodium ion export across plasma membrane
E0043269biological_processregulation of monoatomic ion transport
E0055085biological_processtransmembrane transport
E0099106molecular_functionion channel regulator activity
E1902600biological_processproton transmembrane transport
E1903408biological_processpositive regulation of P-type sodium:potassium-exchanging transporter activity
E1990573biological_processpotassium ion import across plasma membrane
G0001671molecular_functionATPase activator activity
G0005515molecular_functionprotein binding
G0005890cellular_componentsodium:potassium-exchanging ATPase complex
G0006811biological_processmonoatomic ion transport
G0006883biological_processintracellular sodium ion homeostasis
G0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
G0016020cellular_componentmembrane
G0030007biological_processintracellular potassium ion homeostasis
G0030674molecular_functionprotein-macromolecule adaptor activity
G0036376biological_processsodium ion export across plasma membrane
G0043269biological_processregulation of monoatomic ion transport
G0055085biological_processtransmembrane transport
G0099106molecular_functionion channel regulator activity
G1902600biological_processproton transmembrane transport
G1903408biological_processpositive regulation of P-type sodium:potassium-exchanging transporter activity
G1990573biological_processpotassium ion import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
APHD369-THR375

site_idPS00390
Number of Residues21
DetailsATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFiWNsekkefLGRTggsW
ChainResidueDetails
BTRP12-TRP32

site_idPS00391
Number of Residues16
DetailsATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. RkvCRfrlewLgnCSG
ChainResidueDetails
BARG146-GLY161

site_idPS01310
Number of Residues14
DetailsFXYD FXYD family signature. DpFyYDyeTVRngG
ChainResidueDetails
GASP17-GLY30

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues66
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BMET1-LYS34
CTYR817-LYS836
CTHR932-ASN944
CLEU1000-TYR1016
DMET1-LYS34
ATHR332-LEU765
ATYR817-LYS836
ATHR932-ASN944
ALEU1000-TYR1016
CGLY1-PRO80
CLYS146-ILE281
CTHR332-LEU765

site_idSWS_FT_FI2
Number of Residues54
DetailsTRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255
ChainResidueDetails
BILE35-SER62
ATHR979-LYS999
CGLU81-ALA101
CLEU125-ALA145
CGLU282-ILE301
CVAL314-ALA331
CLYS766-ILE785
CGLY796-ALA816
CLEU837-PHE859
CHIS912-LYS931
CLYS945-TYR963
DILE35-SER62
CTHR979-LYS999
AGLU282-ILE301
AVAL314-ALA331
ALYS766-ILE785
AGLY796-ALA816
ALEU837-PHE859
AHIS912-LYS931
ALYS945-TYR963

site_idSWS_FT_FI3
Number of Residues480
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLU63-SER303
CCYS964-PRO978
DGLU63-SER303
APHE786-LEU795
APHE860-CYS911
ACYS964-PRO978
CILE102-TYR124
CLEU302-ALA313
CPHE786-LEU795
CPHE860-CYS911

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07340
ChainResidueDetails
BSER11
DSER11

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P14094
ChainResidueDetails
BTYR101
DTYR101
AASP714
CLYS480
CASP710
CASP714

site_idSWS_FT_FI6
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250
ChainResidueDetails
BASN158
BASN193
BASN265
DASN158
DASN193
DASN265

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ATYR5
CTYR5

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ASER11
CSER11

site_idSWS_FT_FI9
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ASER33
ASER40
ASER445
ASER477
CSER33
CSER40
CSER445
CSER477

site_idSWS_FT_FI10
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ASER221
ASER661
ASER668
CSER221
CSER661
CSER668

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ATYR253
CTYR253

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05023
ChainResidueDetails
ATYR535
CTYR535

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ALYS654
CLYS654

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ASER936
CSER936

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PDB entries from 2024-10-30

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