7DCT
Crystal structure of HSF1 DNA-binding domain in complex with 3-site HSE DNA (24 bp)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003700 | molecular_function | DNA-binding transcription factor activity |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
A | 0043565 | molecular_function | sequence-specific DNA binding |
B | 0003700 | molecular_function | DNA-binding transcription factor activity |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0043565 | molecular_function | sequence-specific DNA binding |
C | 0003700 | molecular_function | DNA-binding transcription factor activity |
C | 0006355 | biological_process | regulation of DNA-templated transcription |
C | 0043565 | molecular_function | sequence-specific DNA binding |
D | 0003700 | molecular_function | DNA-binding transcription factor activity |
D | 0006355 | biological_process | regulation of DNA-templated transcription |
D | 0043565 | molecular_function | sequence-specific DNA binding |
E | 0003700 | molecular_function | DNA-binding transcription factor activity |
E | 0006355 | biological_process | regulation of DNA-templated transcription |
E | 0043565 | molecular_function | sequence-specific DNA binding |
F | 0003700 | molecular_function | DNA-binding transcription factor activity |
F | 0006355 | biological_process | regulation of DNA-templated transcription |
F | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PROSITE/UniProt
site_id | PS00434 |
Number of Residues | 25 |
Details | HSF_DOMAIN HSF-type DNA-binding domain signature. LpkyFKHnNmASFVRQLNmYgFRKV |
Chain | Residue | Details |
A | LEU57-VAL81 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:19229036, ECO:0000269|PubMed:24581496 |
Chain | Residue | Details |
A | LYS80 | |
B | LYS80 | |
C | LYS80 | |
D | LYS80 | |
E | LYS80 | |
F | LYS80 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:24581496 |
Chain | Residue | Details |
A | LYS91 | |
B | LYS91 | |
C | LYS91 | |
D | LYS91 | |
E | LYS91 | |
F | LYS91 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24581496, ECO:0000269|PubMed:26754925 |
Chain | Residue | Details |
A | LYS118 | |
B | LYS118 | |
C | LYS118 | |
D | LYS118 | |
E | LYS118 | |
F | LYS118 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS91 | |
F | LYS91 | |
B | LYS91 | |
C | LYS91 | |
D | LYS91 | |
E | LYS91 |