7DCT
Crystal structure of HSF1 DNA-binding domain in complex with 3-site HSE DNA (24 bp)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0043565 | molecular_function | sequence-specific DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0043565 | molecular_function | sequence-specific DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PROSITE/UniProt
| site_id | PS00434 |
| Number of Residues | 25 |
| Details | HSF_DOMAIN HSF-type DNA-binding domain signature. LpkyFKHnNmASFVRQLNmYgFRKV |
| Chain | Residue | Details |
| A | LEU57-VAL81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:19229036, ECO:0000269|PubMed:24581496 |
| Chain | Residue | Details |
| C | LYS80 | |
| D | LYS80 | |
| E | LYS80 | |
| F | LYS80 | |
| A | LYS80 | |
| B | LYS80 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:24581496 |
| Chain | Residue | Details |
| B | LYS91 | |
| C | LYS91 | |
| D | LYS91 | |
| E | LYS91 | |
| F | LYS91 | |
| A | LYS91 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24581496, ECO:0000269|PubMed:26754925 |
| Chain | Residue | Details |
| E | LYS118 | |
| B | LYS118 | |
| D | LYS118 | |
| F | LYS118 | |
| C | LYS118 | |
| A | LYS118 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS91 | |
| B | LYS91 | |
| C | LYS91 | |
| D | LYS91 | |
| E | LYS91 | |
| F | LYS91 |
