7DBL
Acyl-CoA hydrolase MpaH' mutant S139A in complex with MPA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005782 | cellular_component | peroxisomal matrix |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| A | 0072330 | biological_process | monocarboxylic acid biosynthetic process |
| A | 0140722 | biological_process | mycophenolic acid biosynthetic process |
| B | 0005782 | cellular_component | peroxisomal matrix |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| B | 0072330 | biological_process | monocarboxylic acid biosynthetic process |
| B | 0140722 | biological_process | mycophenolic acid biosynthetic process |
| C | 0005782 | cellular_component | peroxisomal matrix |
| C | 0016114 | biological_process | terpenoid biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0017000 | biological_process | antibiotic biosynthetic process |
| C | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| C | 0072330 | biological_process | monocarboxylic acid biosynthetic process |
| C | 0140722 | biological_process | mycophenolic acid biosynthetic process |
| D | 0005782 | cellular_component | peroxisomal matrix |
| D | 0016114 | biological_process | terpenoid biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0017000 | biological_process | antibiotic biosynthetic process |
| D | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| D | 0072330 | biological_process | monocarboxylic acid biosynthetic process |
| D | 0140722 | biological_process | mycophenolic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue MOA A 501 |
| Chain | Residue |
| A | GLY59 |
| A | ARG301 |
| A | PRO304 |
| A | PHE327 |
| A | HIS365 |
| A | VAL60 |
| A | ALA139 |
| A | PHE140 |
| A | GLN167 |
| A | SER169 |
| A | PRO171 |
| A | ILE183 |
| A | GLN265 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue MOA B 501 |
| Chain | Residue |
| B | GLY59 |
| B | VAL60 |
| B | ALA139 |
| B | PHE140 |
| B | LEU165 |
| B | GLN167 |
| B | PRO171 |
| B | ALA182 |
| B | ILE183 |
| B | GLN265 |
| B | ARG301 |
| B | PHE327 |
| B | HIS365 |
| B | HOH662 |
| B | HOH775 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue MOA C 501 |
| Chain | Residue |
| C | GLY59 |
| C | VAL60 |
| C | ALA139 |
| C | PHE140 |
| C | LEU165 |
| C | GLN167 |
| C | PRO171 |
| C | ALA182 |
| C | ILE183 |
| C | GLN265 |
| C | ARG301 |
| C | PRO304 |
| C | PHE327 |
| C | HIS365 |
| C | HOH649 |
| C | HOH750 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue MOA D 501 |
| Chain | Residue |
| D | GLY59 |
| D | VAL60 |
| D | ALA139 |
| D | PHE140 |
| D | GLN167 |
| D | PRO171 |
| D | GLN265 |
| D | ARG301 |
| D | PRO304 |
| D | PHE327 |
| D | HIS365 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 752 |
| Details | Region: {"description":"Abhydrolase domain","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"31209052","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33843134","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"33843134","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31209052","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33843134","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DBL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
