7DBL

Acyl-CoA hydrolase MpaH' mutant S139A in complex with MPA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0016114	biological_process	terpenoid biosynthetic process
A	0016218	molecular_function	polyketide synthase activity
A	0016787	molecular_function	hydrolase activity
A	0017000	biological_process	antibiotic biosynthetic process
A	0047617	molecular_function	fatty acyl-CoA hydrolase activity
A	0072330	biological_process	monocarboxylic acid biosynthetic process
A	0140722	biological_process	mycophenolic acid biosynthetic process
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0016114	biological_process	terpenoid biosynthetic process
B	0016218	molecular_function	polyketide synthase activity
B	0016787	molecular_function	hydrolase activity
B	0017000	biological_process	antibiotic biosynthetic process
B	0047617	molecular_function	fatty acyl-CoA hydrolase activity
B	0072330	biological_process	monocarboxylic acid biosynthetic process
B	0140722	biological_process	mycophenolic acid biosynthetic process
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0016114	biological_process	terpenoid biosynthetic process
C	0016218	molecular_function	polyketide synthase activity
C	0016787	molecular_function	hydrolase activity
C	0017000	biological_process	antibiotic biosynthetic process
C	0047617	molecular_function	fatty acyl-CoA hydrolase activity
C	0072330	biological_process	monocarboxylic acid biosynthetic process
C	0140722	biological_process	mycophenolic acid biosynthetic process
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0016114	biological_process	terpenoid biosynthetic process
D	0016218	molecular_function	polyketide synthase activity
D	0016787	molecular_function	hydrolase activity
D	0017000	biological_process	antibiotic biosynthetic process
D	0047617	molecular_function	fatty acyl-CoA hydrolase activity
D	0072330	biological_process	monocarboxylic acid biosynthetic process
D	0140722	biological_process	mycophenolic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue MOA A 501

Chain	Residue
A	GLY59
A	ARG301
A	PRO304
A	PHE327
A	HIS365
A	VAL60
A	ALA139
A	PHE140
A	GLN167
A	SER169
A	PRO171
A	ILE183
A	GLN265

---

site_id	AC2
Number of Residues	15
Details	binding site for residue MOA B 501

Chain	Residue
B	GLY59
B	VAL60
B	ALA139
B	PHE140
B	LEU165
B	GLN167
B	PRO171
B	ALA182
B	ILE183
B	GLN265
B	ARG301
B	PHE327
B	HIS365
B	HOH662
B	HOH775

---

site_id	AC3
Number of Residues	16
Details	binding site for residue MOA C 501

Chain	Residue
C	GLY59
C	VAL60
C	ALA139
C	PHE140
C	LEU165
C	GLN167
C	PRO171
C	ALA182
C	ILE183
C	GLN265
C	ARG301
C	PRO304
C	PHE327
C	HIS365
C	HOH649
C	HOH750

---

site_id	AC4
Number of Residues	11
Details	binding site for residue MOA D 501

Chain	Residue
D	GLY59
D	VAL60
D	ALA139
D	PHE140
D	GLN167
D	PRO171
D	GLN265
D	ARG301
D	PRO304
D	PHE327
D	HIS365

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:31209052, ECO:0000269|PubMed:33843134

Chain	Residue	Details
A	ALA139
B	ALA139
C	ALA139
D	ALA139

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:33843134, ECO:0000305|PubMed:31209052

Chain	Residue	Details
A	ASP163
A	HIS365
B	ASP163
B	HIS365
C	ASP163
C	HIS365
D	ASP163
D	HIS365

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:33843134, ECO:0007744|PDB:7DBL

Chain	Residue	Details
A	VAL60
A	PHE140
B	VAL60
B	PHE140
C	VAL60
C	PHE140
D	VAL60
D	PHE140

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