7DAZ
Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in TDP015- and GSH-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004769 | molecular_function | steroid Delta-isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006694 | biological_process | steroid biosynthetic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0045456 | biological_process | ecdysteroid biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004769 | molecular_function | steroid Delta-isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006694 | biological_process | steroid biosynthetic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042632 | biological_process | cholesterol homeostasis |
| B | 0045456 | biological_process | ecdysteroid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue GSH A 301 |
| Chain | Residue |
| A | SER14 |
| A | SER70 |
| A | HIS71 |
| A | PHE110 |
| A | H29303 |
| A | HOH447 |
| A | HOH481 |
| B | SER107 |
| A | PRO16 |
| A | LEU38 |
| A | GLN43 |
| A | HIS55 |
| A | SER56 |
| A | VAL57 |
| A | PRO58 |
| A | ASP69 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue H29 A 302 |
| Chain | Residue |
| A | SER114 |
| A | MET117 |
| A | SER118 |
| A | H29303 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue H29 A 303 |
| Chain | Residue |
| A | ARG13 |
| A | LEU38 |
| A | PHE39 |
| A | LEU208 |
| A | THR211 |
| A | GSH301 |
| A | H29302 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue GSH B 301 |
| Chain | Residue |
| A | SER107 |
| B | SER14 |
| B | GLN43 |
| B | HIS55 |
| B | SER56 |
| B | VAL57 |
| B | PRO58 |
| B | ASP69 |
| B | SER70 |
| B | HIS71 |
| B | PHE110 |
| B | H29303 |
| B | HOH407 |
| B | HOH414 |
| B | HOH422 |
| B | HOH473 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue H29 B 302 |
| Chain | Residue |
| B | SER114 |
| B | MET117 |
| B | SER118 |
| B | H29303 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue H29 B 303 |
| Chain | Residue |
| B | ARG13 |
| B | LEU38 |
| B | PHE39 |
| B | THR211 |
| B | GSH301 |
| B | H29302 |
| B | HOH506 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 162 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 254 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
