7D9U
Structure of human soluble guanylate cyclase in the cinciguat-bound activated state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004383 | molecular_function | guanylate cyclase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006182 | biological_process | cGMP biosynthetic process |
| A | 0008074 | cellular_component | guanylate cyclase complex, soluble |
| A | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0038060 | biological_process | nitric oxide-cGMP-mediated signaling |
| A | 0070482 | biological_process | response to oxygen levels |
| A | 0098925 | biological_process | retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0098982 | cellular_component | GABA-ergic synapse |
| B | 0004016 | molecular_function | adenylate cyclase activity |
| B | 0004383 | molecular_function | guanylate cyclase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006182 | biological_process | cGMP biosynthetic process |
| B | 0008074 | cellular_component | guanylate cyclase complex, soluble |
| B | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0038060 | biological_process | nitric oxide-cGMP-mediated signaling |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0047805 | molecular_function | cytidylate cyclase activity |
| B | 0051879 | molecular_function | Hsp90 protein binding |
| B | 0070026 | molecular_function | nitric oxide binding |
| B | 0070482 | biological_process | response to oxygen levels |
| B | 0071732 | biological_process | cellular response to nitric oxide |
| B | 0098831 | cellular_component | presynaptic active zone cytoplasmic component |
| B | 0098978 | cellular_component | glutamatergic synapse |
Functional Information from PROSITE/UniProt
| site_id | PS00452 |
| Number of Residues | 24 |
| Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVI.GqrmprYcLFGNTVNltsrtE |
| Chain | Residue | Details |
| B | GLY531-GLU554 | |
| A | GLY585-GLU608 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 127 |
| Details | Domain: {"description":"Guanylate cyclase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"7D9U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"6JT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 183 |
| Details | Domain: {"description":"H-NOX","evidences":[{"source":"PROSITE-ProRule","id":"PRU01436","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34535643","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6JT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PDB","id":"8HBE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"7D9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"8HBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6JT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
