7D8Z
human potassium-chloride co-transporter KCC2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0006971 | biological_process | hypotonic response |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0007612 | biological_process | learning |
| A | 0008519 | molecular_function | ammonium channel activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030425 | cellular_component | dendrite |
| A | 0030644 | biological_process | intracellular chloride ion homeostasis |
| A | 0032502 | biological_process | developmental process |
| A | 0032590 | cellular_component | dendrite membrane |
| A | 0035264 | biological_process | multicellular organism growth |
| A | 0040040 | biological_process | thermosensory behavior |
| A | 0042995 | cellular_component | cell projection |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043204 | cellular_component | perikaryon |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051452 | biological_process | intracellular pH reduction |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060996 | biological_process | dendritic spine development |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0071944 | cellular_component | cell periphery |
| A | 0072488 | biological_process | ammonium transmembrane transport |
| A | 0098970 | biological_process | postsynaptic neurotransmitter receptor diffusion trapping |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099634 | cellular_component | postsynaptic specialization membrane |
| A | 0150052 | biological_process | regulation of postsynapse assembly |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0006971 | biological_process | hypotonic response |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0007612 | biological_process | learning |
| B | 0008519 | molecular_function | ammonium channel activity |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0015379 | molecular_function | potassium:chloride symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030425 | cellular_component | dendrite |
| B | 0030644 | biological_process | intracellular chloride ion homeostasis |
| B | 0032502 | biological_process | developmental process |
| B | 0032590 | cellular_component | dendrite membrane |
| B | 0035264 | biological_process | multicellular organism growth |
| B | 0040040 | biological_process | thermosensory behavior |
| B | 0042995 | cellular_component | cell projection |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0043204 | cellular_component | perikaryon |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051452 | biological_process | intracellular pH reduction |
| B | 0055064 | biological_process | chloride ion homeostasis |
| B | 0055075 | biological_process | potassium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0060996 | biological_process | dendritic spine development |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0071944 | cellular_component | cell periphery |
| B | 0072488 | biological_process | ammonium transmembrane transport |
| B | 0098970 | biological_process | postsynaptic neurotransmitter receptor diffusion trapping |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099634 | cellular_component | postsynaptic specialization membrane |
| B | 0150052 | biological_process | regulation of postsynapse assembly |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 320 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | MET1-SER98 | |
| A | GLU579-TYR592 | |
| B | ILE152-SER174 | |
| B | SER421-ILE429 | |
| B | SER514-GLN534 | |
| B | GLU579-TYR592 | |
| A | MET1-SER98 | |
| A | ILE152-SER174 | |
| A | SER421-ILE429 | |
| A | SER514-GLN534 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | TRANSMEM: Discontinuously helical; Name=1 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | ARG99-MET120 | |
| A | ARG99-MET120 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 378 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | GLY121-PRO129 | |
| B | GLY204-TYR229 | |
| B | LYS277-LEU402 | |
| B | ILE454-LEU485 | |
| A | GLY121-PRO129 | |
| A | GLY204-TYR229 | |
| A | LYS277-LEU402 | |
| A | ILE454-LEU485 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | CYS130-GLY151 | |
| A | CYS130-GLY151 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | ALA175-VAL203 | |
| A | ALA175-VAL203 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | LEU230-LEU250 | |
| A | LEU230-LEU250 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | ASN251-ASN276 | |
| A | ASN251-ASN276 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | ALA403-THR420 | |
| A | ALA403-THR420 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | TYR430-SER453 | |
| A | TYR430-SER453 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | ARG486-GLY513 | |
| A | ARG486-GLY513 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | ALA535-GLY555 | |
| A | ALA535-GLY555 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | GLU556-ASP578 | |
| A | GLU556-ASP578 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | MET593-ARG615 | |
| A | MET593-ARG615 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | TYR616-LEU632 | |
| A | TYR616-LEU632 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1012 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:33310850, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | MET633-SER1139 | |
| A | MET633-SER1139 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33310850, ECO:0007744|PDB:6M23 |
| Chain | Residue | Details |
| B | LYS113 | |
| A | MET410 | |
| A | TYR414 | |
| A | VAL415 | |
| A | ASP446 | |
| A | GLU569 | |
| B | ALA184 | |
| B | MET410 | |
| B | TYR414 | |
| B | VAL415 | |
| B | ASP446 | |
| B | GLU569 | |
| A | LYS113 | |
| A | ALA184 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63633 |
| Chain | Residue | Details |
| B | THR57 | |
| A | THR57 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| B | THR929 | |
| B | THR1030 | |
| A | THR929 | |
| A | THR1030 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91V14 |
| Chain | Residue | Details |
| B | SER1045 | |
| B | SER1048 | |
| B | SER1049 | |
| A | SER1045 | |
| A | SER1048 | |
| A | SER1049 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN314 | |
| B | ASN333 | |
| B | ASN351 | |
| B | ASN362 | |
| A | ASN314 | |
| A | ASN333 | |
| A | ASN351 | |
| A | ASN362 |
