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7D8Z

human potassium-chloride co-transporter KCC2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006821biological_processchloride transport
A0006884biological_processcell volume homeostasis
A0006971biological_processhypotonic response
A0007268biological_processchemical synaptic transmission
A0007612biological_processlearning
A0008519molecular_functionammonium channel activity
A0009410biological_processresponse to xenobiotic stimulus
A0015108molecular_functionchloride transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015377molecular_functionchloride:monoatomic cation symporter activity
A0015379molecular_functionpotassium:chloride symporter activity
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0030425cellular_componentdendrite
A0030644biological_processintracellular chloride ion homeostasis
A0032590cellular_componentdendrite membrane
A0035264biological_processmulticellular organism growth
A0040040biological_processthermosensory behavior
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043204cellular_componentperikaryon
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0051452biological_processintracellular pH reduction
A0055064biological_processchloride ion homeostasis
A0055075biological_processpotassium ion homeostasis
A0055085biological_processtransmembrane transport
A0060996biological_processdendritic spine development
A0071805biological_processpotassium ion transmembrane transport
A0071944cellular_componentcell periphery
A0072488biological_processammonium transmembrane transport
A1902476biological_processchloride transmembrane transport
A1990573biological_processpotassium ion import across plasma membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006821biological_processchloride transport
B0006884biological_processcell volume homeostasis
B0006971biological_processhypotonic response
B0007268biological_processchemical synaptic transmission
B0007612biological_processlearning
B0008519molecular_functionammonium channel activity
B0009410biological_processresponse to xenobiotic stimulus
B0015108molecular_functionchloride transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015377molecular_functionchloride:monoatomic cation symporter activity
B0015379molecular_functionpotassium:chloride symporter activity
B0016020cellular_componentmembrane
B0022857molecular_functiontransmembrane transporter activity
B0030425cellular_componentdendrite
B0030644biological_processintracellular chloride ion homeostasis
B0032590cellular_componentdendrite membrane
B0035264biological_processmulticellular organism growth
B0040040biological_processthermosensory behavior
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043204cellular_componentperikaryon
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0051452biological_processintracellular pH reduction
B0055064biological_processchloride ion homeostasis
B0055075biological_processpotassium ion homeostasis
B0055085biological_processtransmembrane transport
B0060996biological_processdendritic spine development
B0071805biological_processpotassium ion transmembrane transport
B0071944cellular_componentcell periphery
B0072488biological_processammonium transmembrane transport
B1902476biological_processchloride transmembrane transport
B1990573biological_processpotassium ion import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1334
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q91V14
ChainResidueDetails
BMET1-THR122
AARG538-PRO557
AGLN602-HIS618
AGLU656-SER1139
BALA177-PRO197
BSER444-LYS452
BARG538-PRO557
BGLN602-HIS618
BGLU656-SER1139
AMET1-THR122
AALA177-PRO197
ASER444-LYS452

site_idSWS_FT_FI2
Number of Residues40
DetailsTRANSMEM: Discontinuously helical => ECO:0000250|UniProtKB:Q91V14
ChainResidueDetails
BPHE123-LEU143
APHE123-LEU143

site_idSWS_FT_FI3
Number of Residues370
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q91V14
ChainResidueDetails
BTHR144-GLY151
AGLY477-TRP508
AALA575-SER576
ASER637
BALA228-ASN251
BSER300-TYR422
BGLY477-TRP508
BALA575-SER576
BSER637
ATHR144-GLY151
AALA228-ASN251
ASER300-TYR422

site_idSWS_FT_FI4
Number of Residues488
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:Q91V14
ChainResidueDetails
BILE152-ILE176
BTRP619-CYS636
BTRP638-ILE655
AILE152-ILE176
AGLU198-LEU227
AASN252-LYS273
ATYR274-LYS299
APHE423-ARG443
ASER453-PHE476
AVAL509-SER537
ATHR558-ILE574
BGLU198-LEU227
ALEU577-VAL601
ATRP619-CYS636
ATRP638-ILE655
BASN252-LYS273
BTYR274-LYS299
BPHE423-ARG443
BSER453-PHE476
BVAL509-SER537
BTHR558-ILE574
BLEU577-VAL601

site_idSWS_FT_FI5
Number of Residues18
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9UP95
ChainResidueDetails
BASN133
AASN133
AILE134
ATYR218
APRO432
ATHR435
AGLY436
AILE437
AMET438
ATYR592
BILE134
BTYR218
BPRO432
BTHR435
BGLY436
BILE437
BMET438
BTYR592

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63633
ChainResidueDetails
BTHR57
ATHR57

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974
ChainResidueDetails
BTHR929
BTHR1030
ATHR929
ATHR1030

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91V14
ChainResidueDetails
BSER1045
BSER1048
BSER1049
ASER1045
ASER1048
ASER1049

site_idSWS_FT_FI9
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN314
BASN333
BASN351
BASN362
AASN314
AASN333
AASN351
AASN362

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PDB entries from 2024-07-24

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