7D74

Cryo-EM structure of GMPPA/GMPPB complex bound to GTP (state II)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
A	0004857	molecular_function	enzyme inhibitor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006486	biological_process	obsolete protein glycosylation
A	0009058	biological_process	biosynthetic process
A	0009100	biological_process	glycoprotein metabolic process
A	0009298	biological_process	GDP-mannose biosynthetic process
A	0009890	biological_process	negative regulation of biosynthetic process
A	0016740	molecular_function	transferase activity
A	0019673	biological_process	GDP-mannose metabolic process
A	0019899	molecular_function	enzyme binding
A	0021537	biological_process	telencephalon development
A	0045934	biological_process	negative regulation of nucleobase-containing compound metabolic process
A	0045936	biological_process	negative regulation of phosphate metabolic process
A	0048644	biological_process	muscle organ morphogenesis
A	0050890	biological_process	cognition
A	0050905	biological_process	neuromuscular process
A	0051402	biological_process	neuron apoptotic process
A	0060538	biological_process	skeletal muscle organ development
A	0061744	biological_process	motor behavior
A	0062014	biological_process	negative regulation of small molecule metabolic process
A	0070062	cellular_component	extracellular exosome
A	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
A	0140299	molecular_function	molecular sensor activity
B	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
B	0004857	molecular_function	enzyme inhibitor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006486	biological_process	obsolete protein glycosylation
B	0009058	biological_process	biosynthetic process
B	0009100	biological_process	glycoprotein metabolic process
B	0009298	biological_process	GDP-mannose biosynthetic process
B	0009890	biological_process	negative regulation of biosynthetic process
B	0016740	molecular_function	transferase activity
B	0019673	biological_process	GDP-mannose metabolic process
B	0019899	molecular_function	enzyme binding
B	0021537	biological_process	telencephalon development
B	0045934	biological_process	negative regulation of nucleobase-containing compound metabolic process
B	0045936	biological_process	negative regulation of phosphate metabolic process
B	0048644	biological_process	muscle organ morphogenesis
B	0050890	biological_process	cognition
B	0050905	biological_process	neuromuscular process
B	0051402	biological_process	neuron apoptotic process
B	0060538	biological_process	skeletal muscle organ development
B	0061744	biological_process	motor behavior
B	0062014	biological_process	negative regulation of small molecule metabolic process
B	0070062	cellular_component	extracellular exosome
B	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
B	0140299	molecular_function	molecular sensor activity
C	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
C	0004857	molecular_function	enzyme inhibitor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006486	biological_process	obsolete protein glycosylation
C	0009058	biological_process	biosynthetic process
C	0009100	biological_process	glycoprotein metabolic process
C	0009298	biological_process	GDP-mannose biosynthetic process
C	0009890	biological_process	negative regulation of biosynthetic process
C	0016740	molecular_function	transferase activity
C	0019673	biological_process	GDP-mannose metabolic process
C	0019899	molecular_function	enzyme binding
C	0021537	biological_process	telencephalon development
C	0045934	biological_process	negative regulation of nucleobase-containing compound metabolic process
C	0045936	biological_process	negative regulation of phosphate metabolic process
C	0048644	biological_process	muscle organ morphogenesis
C	0050890	biological_process	cognition
C	0050905	biological_process	neuromuscular process
C	0051402	biological_process	neuron apoptotic process
C	0060538	biological_process	skeletal muscle organ development
C	0061744	biological_process	motor behavior
C	0062014	biological_process	negative regulation of small molecule metabolic process
C	0070062	cellular_component	extracellular exosome
C	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
C	0140299	molecular_function	molecular sensor activity
D	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
D	0004857	molecular_function	enzyme inhibitor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006486	biological_process	obsolete protein glycosylation
D	0009058	biological_process	biosynthetic process
D	0009100	biological_process	glycoprotein metabolic process
D	0009298	biological_process	GDP-mannose biosynthetic process
D	0009890	biological_process	negative regulation of biosynthetic process
D	0016740	molecular_function	transferase activity
D	0019673	biological_process	GDP-mannose metabolic process
D	0019899	molecular_function	enzyme binding
D	0021537	biological_process	telencephalon development
D	0045934	biological_process	negative regulation of nucleobase-containing compound metabolic process
D	0045936	biological_process	negative regulation of phosphate metabolic process
D	0048644	biological_process	muscle organ morphogenesis
D	0050890	biological_process	cognition
D	0050905	biological_process	neuromuscular process
D	0051402	biological_process	neuron apoptotic process
D	0060538	biological_process	skeletal muscle organ development
D	0061744	biological_process	motor behavior
D	0062014	biological_process	negative regulation of small molecule metabolic process
D	0070062	cellular_component	extracellular exosome
D	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
D	0140299	molecular_function	molecular sensor activity
E	0000166	molecular_function	nucleotide binding
E	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009058	biological_process	biosynthetic process
E	0009298	biological_process	GDP-mannose biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0019673	biological_process	GDP-mannose metabolic process
E	0046872	molecular_function	metal ion binding
E	0061728	biological_process	GDP-mannose biosynthetic process from mannose
E	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
F	0000166	molecular_function	nucleotide binding
F	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009058	biological_process	biosynthetic process
F	0009298	biological_process	GDP-mannose biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0019673	biological_process	GDP-mannose metabolic process
F	0046872	molecular_function	metal ion binding
F	0061728	biological_process	GDP-mannose biosynthetic process from mannose
F	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
G	0000166	molecular_function	nucleotide binding
G	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0009058	biological_process	biosynthetic process
G	0009298	biological_process	GDP-mannose biosynthetic process
G	0016740	molecular_function	transferase activity
G	0016779	molecular_function	nucleotidyltransferase activity
G	0019673	biological_process	GDP-mannose metabolic process
G	0046872	molecular_function	metal ion binding
G	0061728	biological_process	GDP-mannose biosynthetic process from mannose
G	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
H	0000166	molecular_function	nucleotide binding
H	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0009058	biological_process	biosynthetic process
H	0009298	biological_process	GDP-mannose biosynthetic process
H	0016740	molecular_function	transferase activity
H	0016779	molecular_function	nucleotidyltransferase activity
H	0019673	biological_process	GDP-mannose metabolic process
H	0046872	molecular_function	metal ion binding
H	0061728	biological_process	GDP-mannose biosynthetic process from mannose
H	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
I	0000166	molecular_function	nucleotide binding
I	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0009058	biological_process	biosynthetic process
I	0009298	biological_process	GDP-mannose biosynthetic process
I	0016740	molecular_function	transferase activity
I	0016779	molecular_function	nucleotidyltransferase activity
I	0019673	biological_process	GDP-mannose metabolic process
I	0046872	molecular_function	metal ion binding
I	0061728	biological_process	GDP-mannose biosynthetic process from mannose
I	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
J	0000166	molecular_function	nucleotide binding
J	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0009058	biological_process	biosynthetic process
J	0009298	biological_process	GDP-mannose biosynthetic process
J	0016740	molecular_function	transferase activity
J	0016779	molecular_function	nucleotidyltransferase activity
J	0019673	biological_process	GDP-mannose metabolic process
J	0046872	molecular_function	metal ion binding
J	0061728	biological_process	GDP-mannose biosynthetic process from mannose
J	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
K	0000166	molecular_function	nucleotide binding
K	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0009058	biological_process	biosynthetic process
K	0009298	biological_process	GDP-mannose biosynthetic process
K	0016740	molecular_function	transferase activity
K	0016779	molecular_function	nucleotidyltransferase activity
K	0019673	biological_process	GDP-mannose metabolic process
K	0046872	molecular_function	metal ion binding
K	0061728	biological_process	GDP-mannose biosynthetic process from mannose
K	0120508	cellular_component	GDP-mannose pyrophosphorylase complex
L	0000166	molecular_function	nucleotide binding
L	0004475	molecular_function	mannose-1-phosphate guanylyltransferase (GTP) activity
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0009058	biological_process	biosynthetic process
L	0009298	biological_process	GDP-mannose biosynthetic process
L	0016740	molecular_function	transferase activity
L	0016779	molecular_function	nucleotidyltransferase activity
L	0019673	biological_process	GDP-mannose metabolic process
L	0046872	molecular_function	metal ion binding
L	0061728	biological_process	GDP-mannose biosynthetic process from mannose
L	0120508	cellular_component	GDP-mannose pyrophosphorylase complex

Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. VApsAvLgpnVsIGkgVtVGegVrLresI

Chain	Residue	Details
A	VAL295-ILE323
E	VAL256-VAL284

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1508
Details	Region: {"description":"Hexapeptide repeat domain","evidences":[{"source":"PubMed","id":"33986552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	Region: {"description":"C-loop","evidences":[{"source":"PubMed","id":"33986552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33986552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1540
Details	Region: {"description":"Substrate-binding domain","evidences":[{"source":"PubMed","id":"33986552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PubMed","id":"33986552","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---