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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7D65

Cryo-EM Structure of human CALHM5 in the presence of Ca2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A1904669biological_processATP export
B0005261molecular_functionmonoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0098655biological_processmonoatomic cation transmembrane transport
B1904669biological_processATP export
C0005261molecular_functionmonoatomic cation channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0098655biological_processmonoatomic cation transmembrane transport
C1904669biological_processATP export
D0005261molecular_functionmonoatomic cation channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D1904669biological_processATP export
E0005261molecular_functionmonoatomic cation channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
E0098655biological_processmonoatomic cation transmembrane transport
E1904669biological_processATP export
F0005261molecular_functionmonoatomic cation channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0016020cellular_componentmembrane
F0034220biological_processmonoatomic ion transmembrane transport
F0098655biological_processmonoatomic cation transmembrane transport
F1904669biological_processATP export
G0005261molecular_functionmonoatomic cation channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0016020cellular_componentmembrane
G0034220biological_processmonoatomic ion transmembrane transport
G0098655biological_processmonoatomic cation transmembrane transport
G1904669biological_processATP export
H0005261molecular_functionmonoatomic cation channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0016020cellular_componentmembrane
H0034220biological_processmonoatomic ion transmembrane transport
H0098655biological_processmonoatomic cation transmembrane transport
H1904669biological_processATP export
I0005261molecular_functionmonoatomic cation channel activity
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0006811biological_processmonoatomic ion transport
I0016020cellular_componentmembrane
I0034220biological_processmonoatomic ion transmembrane transport
I0098655biological_processmonoatomic cation transmembrane transport
I1904669biological_processATP export
J0005261molecular_functionmonoatomic cation channel activity
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0016020cellular_componentmembrane
J0034220biological_processmonoatomic ion transmembrane transport
J0098655biological_processmonoatomic cation transmembrane transport
J1904669biological_processATP export
K0005261molecular_functionmonoatomic cation channel activity
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0006811biological_processmonoatomic ion transport
K0016020cellular_componentmembrane
K0034220biological_processmonoatomic ion transmembrane transport
K0098655biological_processmonoatomic cation transmembrane transport
K1904669biological_processATP export
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues462
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues231
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"33298887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues561
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues264
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"33298887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues319
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"33298887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues275
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"33298887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues33
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33298887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33298887","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33298887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D61","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-11-05

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