Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004822 | molecular_function | isoleucine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006428 | biological_process | isoleucyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue GVU A 1001 |
| Chain | Residue |
| A | GLY88 |
| A | ARG567 |
| A | SER604 |
| A | LYS605 |
| A | SER606 |
| A | HOH1106 |
| A | HOH1163 |
| A | HOH1200 |
| A | HOH1202 |
| A | HOH1205 |
| A | HOH1345 |
| A | VAL89 |
| A | HOH1403 |
| A | HOH1420 |
| A | HOH1436 |
| A | HOH1484 |
| A | HOH1539 |
| A | PHE191 |
| A | ARG454 |
| A | ARG460 |
| A | ASP527 |
| A | CYS528 |
| A | TRP529 |
| A | ASP564 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue GV6 A 1002 |
| Chain | Residue |
| A | PRO46 |
| A | PRO47 |
| A | PHE48 |
| A | HIS54 |
| A | GLY56 |
| A | HIS57 |
| A | ASP85 |
| A | SER532 |
| A | GLU561 |
| A | GLY562 |
| A | GLN565 |
| A | GLY593 |
| A | ILE594 |
| A | VAL595 |
| A | HOH1113 |
| A | HOH1130 |
| A | HOH1141 |
| A | HOH1215 |
| A | HOH1264 |
| A | HOH1350 |
| A | HOH1628 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1003 |
| Chain | Residue |
| A | ARG251 |
| A | LEU265 |
| A | LEU389 |
| A | HOH1206 |
| A | HOH1532 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1004 |
| Chain | Residue |
| A | SER430 |
| A | LYS433 |
| A | SER583 |
| A | VAL584 |
| A | TYR586 |
| A | HOH1157 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1005 |
| Chain | Residue |
| A | GLY562 |
| A | LEU563 |
| A | ASP564 |
| A | HOH1264 |
| A | HOH1294 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PfaTGtPHYGHI |
| Chain | Residue | Details |
| A | PRO47-ILE58 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS605 | |
| Chain | Residue | Details |
| A | SER829 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS486 | |
