7CXD

Xray structure of rat Galectin-3 CRD in complex with TD-139 belonging to P121 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0030246	molecular_function	carbohydrate binding
B	0030246	molecular_function	carbohydrate binding
D	0030246	molecular_function	carbohydrate binding
E	0030246	molecular_function	carbohydrate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue BR A 301

Chain	Residue
A	ASN160
A	LYS162
A	ILE249

---

site_id	AC2
Number of Residues	12
Details	binding site for residue TD2 A 302

Chain	Residue
A	TRP193
A	GLU196
A	ARG198
A	HOH404
A	HOH427
A	HOH446
A	HIS170
A	ASN172
A	ARG174
A	GLU177
A	ASN178
A	ASN186

---

site_id	AC3
Number of Residues	2
Details	binding site for residue BR B 301

Chain	Residue
B	ASN160
B	LYS162

---

site_id	AC4
Number of Residues	17
Details	binding site for residue TD2 B 302

Chain	Residue
B	HIS170
B	ASN172
B	ARG174
B	GLU177
B	ASN178
B	ASN186
B	GLU196
B	ARG198
B	HOH402
B	HOH406
B	HOH412
B	HOH431
E	ARG174
E	GLU177
E	ASN178
E	TD2302
E	HOH422

---

site_id	AC5
Number of Residues	2
Details	binding site for residue BR D 301

Chain	Residue
D	ASN160
D	LYS162

---

site_id	AC6
Number of Residues	2
Details	binding site for residue BR D 302

Chain	Residue
A	ARG180
D	PRO129

---

site_id	AC7
Number of Residues	12
Details	binding site for residue TD2 D 303

Chain	Residue
D	HIS170
D	ASN172
D	ARG174
D	GLU177
D	ASN178
D	ASN186
D	GLU196
D	ARG198
D	HOH410
D	HOH411
D	HOH425
D	HOH446

---

site_id	AC8
Number of Residues	3
Details	binding site for residue BR E 301

Chain	Residue
E	ASN160
E	LYS162
E	GLY247

---

site_id	AC9
Number of Residues	18
Details	binding site for residue TD2 E 302

Chain	Residue
B	GLU177
B	ASN178
B	TD2302
E	HIS170
E	ASN172
E	ARG174
E	GLU177
E	ASN178
E	ARG180
E	ASN186
E	TRP193
E	GLU196
E	ARG198
E	HOH407
E	HOH412
E	HOH422
E	HOH430
E	HOH431

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	520
Details	Domain: {"description":"Galectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00639","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Motif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P17931","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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