7CWZ

Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis K392A mutant in complex with the cofactor PLP and L-dopa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
A	0004837	molecular_function	tyrosine decarboxylase activity
A	0016830	molecular_function	carbon-carbon lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0036468	molecular_function	L-dopa decarboxylase activity
A	1903184	biological_process	L-dopa metabolic process
B	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
B	0004837	molecular_function	tyrosine decarboxylase activity
B	0016830	molecular_function	carbon-carbon lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0036468	molecular_function	L-dopa decarboxylase activity
B	1903184	biological_process	L-dopa metabolic process
C	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
C	0004837	molecular_function	tyrosine decarboxylase activity
C	0016830	molecular_function	carbon-carbon lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0030170	molecular_function	pyridoxal phosphate binding
C	0036468	molecular_function	L-dopa decarboxylase activity
C	1903184	biological_process	L-dopa metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:J7GQ11

Chain	Residue	Details
A	TYR420
B	TYR420
C	TYR420

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: in other chain => ECO:0000250|UniProtKB:J7GQ11

Chain	Residue	Details
B	GLY158
B	THR298
B	ASP389
C	GLY158
C	THR298
C	ASP389
A	GLY158
A	THR298
A	ASP389

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:J7GQ11

Chain	Residue	Details
A	SER440
B	SER440
C	SER440

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250|UniProtKB:J7GQ11

Chain	Residue	Details
A	ALA392
B	ALA392
C	ALA392

---