7CTC

FECH - inhibitor complex 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004325	molecular_function	ferrochelatase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006779	biological_process	porphyrin-containing compound biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0006784	biological_process	heme A biosynthetic process
A	0006785	biological_process	heme B biosynthetic process
A	0008198	molecular_function	ferrous iron binding
A	0009416	biological_process	response to light stimulus
A	0016829	molecular_function	lyase activity
A	0020037	molecular_function	heme binding
A	0030350	molecular_function	iron-responsive element binding
A	0031966	cellular_component	mitochondrial membrane
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0046501	biological_process	protoporphyrinogen IX metabolic process
A	0046872	molecular_function	metal ion binding
A	0046906	molecular_function	tetrapyrrole binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
D	0004325	molecular_function	ferrochelatase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005759	cellular_component	mitochondrial matrix
D	0006091	biological_process	generation of precursor metabolites and energy
D	0006779	biological_process	porphyrin-containing compound biosynthetic process
D	0006783	biological_process	heme biosynthetic process
D	0006784	biological_process	heme A biosynthetic process
D	0006785	biological_process	heme B biosynthetic process
D	0008198	molecular_function	ferrous iron binding
D	0009416	biological_process	response to light stimulus
D	0016829	molecular_function	lyase activity
D	0020037	molecular_function	heme binding
D	0030350	molecular_function	iron-responsive element binding
D	0031966	cellular_component	mitochondrial membrane
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0046501	biological_process	protoporphyrinogen IX metabolic process
D	0046872	molecular_function	metal ion binding
D	0046906	molecular_function	tetrapyrrole binding
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051537	molecular_function	2 iron, 2 sulfur cluster binding

Functional Information from PROSITE/UniProt

site_id	PS00534
Number of Residues	19
Details	FERROCHELATASE Ferrochelatase signature. ILfSaHSLPmsvv.NrGDp...Y

Chain	Residue	Details
A	ILE258-TYR276

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17261801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HRE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17261801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HRK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HRC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P22315","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P22315","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	9
Details	M-CSA 578

Chain	Residue	Details
A	MET76
A	LEU92
A	LEU98
A	ARG164
A	TYR165
A	HIS263	metal ligand, proton acceptor
A	ASP340
A	GLU343	metal ligand, proton acceptor
A	GLU347

---

site_id	MCSA2
Number of Residues	9
Details	M-CSA 578

Chain

Residue

Details

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