Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7CTC

FECH - inhibitor complex 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004325molecular_functionferrochelatase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0006091biological_processgeneration of precursor metabolites and energy
A0006779biological_processporphyrin-containing compound biosynthetic process
A0006783biological_processheme biosynthetic process
A0006784biological_processheme A biosynthetic process
A0006785biological_processheme B biosynthetic process
A0008198molecular_functionferrous iron binding
A0008203biological_processcholesterol metabolic process
A0009410biological_processresponse to xenobiotic stimulus
A0009416biological_processresponse to light stimulus
A0009589biological_processdetection of UV
A0010038biological_processresponse to metal ion
A0010288biological_processresponse to lead ion
A0010999biological_processregulation of eIF2 alpha phosphorylation by heme
A0016829molecular_functionlyase activity
A0017085biological_processresponse to insecticide
A0020037molecular_functionheme binding
A0030218biological_processerythrocyte differentiation
A0030350molecular_functioniron-responsive element binding
A0034379biological_processvery-low-density lipoprotein particle assembly
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0045471biological_processresponse to ethanol
A0046501biological_processprotoporphyrinogen IX metabolic process
A0046685biological_processresponse to arsenic-containing substance
A0046872molecular_functionmetal ion binding
A0046906molecular_functiontetrapyrrole binding
A0046984biological_processregulation of hemoglobin biosynthetic process
A0048034biological_processheme O biosynthetic process
A0051537molecular_function2 iron, 2 sulfur cluster binding
A0051597biological_processresponse to methylmercury
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0070541biological_processresponse to platinum ion
A0071549biological_processcellular response to dexamethasone stimulus
D0004325molecular_functionferrochelatase activity
D0005506molecular_functioniron ion binding
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0006091biological_processgeneration of precursor metabolites and energy
D0006779biological_processporphyrin-containing compound biosynthetic process
D0006783biological_processheme biosynthetic process
D0006784biological_processheme A biosynthetic process
D0006785biological_processheme B biosynthetic process
D0008198molecular_functionferrous iron binding
D0008203biological_processcholesterol metabolic process
D0009410biological_processresponse to xenobiotic stimulus
D0009416biological_processresponse to light stimulus
D0009589biological_processdetection of UV
D0010038biological_processresponse to metal ion
D0010288biological_processresponse to lead ion
D0010999biological_processregulation of eIF2 alpha phosphorylation by heme
D0016829molecular_functionlyase activity
D0017085biological_processresponse to insecticide
D0020037molecular_functionheme binding
D0030218biological_processerythrocyte differentiation
D0030350molecular_functioniron-responsive element binding
D0034379biological_processvery-low-density lipoprotein particle assembly
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0045471biological_processresponse to ethanol
D0046501biological_processprotoporphyrinogen IX metabolic process
D0046685biological_processresponse to arsenic-containing substance
D0046872molecular_functionmetal ion binding
D0046906molecular_functiontetrapyrrole binding
D0046984biological_processregulation of hemoglobin biosynthetic process
D0048034biological_processheme O biosynthetic process
D0051537molecular_function2 iron, 2 sulfur cluster binding
D0051597biological_processresponse to methylmercury
D0060586biological_processmulticellular organismal-level iron ion homeostasis
D0070541biological_processresponse to platinum ion
D0071549biological_processcellular response to dexamethasone stimulus
Functional Information from PROSITE/UniProt
site_idPS00534
Number of Residues19
DetailsFERROCHELATASE Ferrochelatase signature. ILfSaHSLPmsvv.NrGDp...Y
ChainResidueDetails
AILE258-TYR276

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE:
ChainResidueDetails
DHIS230
DASP383
AHIS230
AASP383

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING:
ChainResidueDetails
DCYS196
DCYS403
DCYS406
DCYS411
ACYS196
ACYS403
ACYS406
ACYS411

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P22315
ChainResidueDetails
DLYS57
ALYS57

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P22315
ChainResidueDetails
DLYS138
ALYS138

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P22315
ChainResidueDetails
DLYS415
ALYS415

Catalytic Information from CSA
site_idMCSA1
Number of Residues9
DetailsM-CSA 578
ChainResidueDetails
AMET76
ALEU92
ALEU98
AARG164
ATYR165
AHIS263metal ligand, proton acceptor
AASP340
AGLU343metal ligand, proton acceptor
AGLU347

site_idMCSA2
Number of Residues9
DetailsM-CSA 578
ChainResidueDetails
DMET76
DLEU92
DLEU98
DARG164
DTYR165
DHIS263metal ligand, proton acceptor
DASP340
DGLU343metal ligand, proton acceptor
DGLU347

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon