7CQE

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with AZD-7762

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 901

Chain	Residue
A	ARG584
A	LEU589

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site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 903

Chain	Residue
A	LEU819
A	LYS820

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site_id	AC3
Number of Residues	1
Details	binding site for residue CL A 904

Chain	Residue
A	ARG818

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 905

Chain	Residue
A	GLN821
C	THR690

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site_id	AC5
Number of Residues	11
Details	binding site for residue YDJ A 906

Chain	Residue
A	PRO672
A	PHE673
A	MET674
A	LYS675
A	ARG727
A	ASN728
A	MET730
A	ASP741
A	HOH1004
A	LEU593
A	ALA617

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL C 901

Chain	Residue
C	PRO802
C	LEU819
C	LYS820

---

site_id	AC7
Number of Residues	12
Details	binding site for residue YDJ C 902

Chain	Residue
C	VAL601
C	ALA617
C	LYS619
C	PRO672
C	PHE673
C	MET674
C	LYS675
C	ARG727
C	ASN728
C	MET730
C	ASP741
C	HOH1005

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGEFGSVMeGnlkqedgtslk.......VAVK

Chain	Residue	Details
A	LEU593-LYS619

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCML

Chain	Residue	Details
A	PHE719-LEU731

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP723
C	ASP723

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU593
A	LYS615
C	LEU593
C	LYS615

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8702477

Chain	Residue	Details
A	TYR749
A	TYR753
A	TYR754
C	TYR749
C	TYR753
C	TYR754

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