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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7CPY

Lovastatin nonaketide synthase with LovC

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004312molecular_functionfatty acid synthase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0005524molecular_functionATP binding
A0006633biological_processfatty acid biosynthetic process
A0008168molecular_functionmethyltransferase activity
A0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
A0009403biological_processtoxin biosynthetic process
A0016218molecular_functionpolyketide synthase activity
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
A0030639biological_processpolyketide biosynthetic process
A0031177molecular_functionphosphopantetheine binding
A0032259biological_processmethylation
A0044281biological_processsmall molecule metabolic process
A0044550biological_processsecondary metabolite biosynthetic process
A0046500biological_processS-adenosylmethionine metabolic process
A0050637molecular_functionlovastatin nonaketide synthase activity
A0140735biological_processlovastatin biosynthetic process
B0003824molecular_functioncatalytic activity
B0004312molecular_functionfatty acid synthase activity
B0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
B0005524molecular_functionATP binding
B0006633biological_processfatty acid biosynthetic process
B0008168molecular_functionmethyltransferase activity
B0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
B0009403biological_processtoxin biosynthetic process
B0016218molecular_functionpolyketide synthase activity
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
B0030639biological_processpolyketide biosynthetic process
B0031177molecular_functionphosphopantetheine binding
B0032259biological_processmethylation
B0044281biological_processsmall molecule metabolic process
B0044550biological_processsecondary metabolite biosynthetic process
B0046500biological_processS-adenosylmethionine metabolic process
B0050637molecular_functionlovastatin nonaketide synthase activity
B0140735biological_processlovastatin biosynthetic process
C0000166molecular_functionnucleotide binding
C0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
C0016218molecular_functionpolyketide synthase activity
C0016491molecular_functionoxidoreductase activity
C0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
C0016740molecular_functiontransferase activity
C0030639biological_processpolyketide biosynthetic process
C0050637molecular_functionlovastatin nonaketide synthase activity
C0070402molecular_functionNADPH binding
C0140735biological_processlovastatin biosynthetic process
D0000166molecular_functionnucleotide binding
D0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
D0016218molecular_functionpolyketide synthase activity
D0016491molecular_functionoxidoreductase activity
D0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
D0016740molecular_functiontransferase activity
D0030639biological_processpolyketide biosynthetic process
D0050637molecular_functionlovastatin nonaketide synthase activity
D0070402molecular_functionNADPH binding
D0140735biological_processlovastatin biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPSmtIDtACSSSlvAV
ChainResidueDetails
AGLY172-VAL188
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22733743","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues272
DetailsRegion: {"description":"N-terminal hotdog fold","evidences":[{"source":"PROSITE-ProRule","id":"PRU01363","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues320
DetailsRegion: {"description":"C-terminal hotdog fold","evidences":[{"source":"PROSITE-ProRule","id":"PRU01363","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues200
DetailsRegion: {"description":"Methyltransferase (CMet) domain","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33558520","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22733743","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsActive site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsActive site: {"description":"For malonyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU10022","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsActive site: {"description":"Proton acceptor; for dehydratase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01363","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsActive site: {"description":"Proton donor; for dehydratase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01363","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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