Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CPN

CRYSTAL STRUCTURE OF DODECAPRENYL DIPHOSPHATE SYNTHASE FROM THERMOBIFIDA FUSCA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0002094	molecular_function	polyprenyltransferase activity
A	0004659	molecular_function	prenyltransferase activity
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008834	molecular_function	di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
A	0016094	biological_process	polyprenol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0030145	molecular_function	manganese ion binding
A	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0002094	molecular_function	polyprenyltransferase activity
B	0004659	molecular_function	prenyltransferase activity
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008834	molecular_function	di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
B	0016094	biological_process	polyprenol biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0030145	molecular_function	manganese ion binding
B	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0002094	molecular_function	polyprenyltransferase activity
C	0004659	molecular_function	prenyltransferase activity
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008834	molecular_function	di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
C	0016094	biological_process	polyprenol biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0030145	molecular_function	manganese ion binding
C	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0002094	molecular_function	polyprenyltransferase activity
D	0004659	molecular_function	prenyltransferase activity
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0008834	molecular_function	di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
D	0016094	biological_process	polyprenol biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0030145	molecular_function	manganese ion binding
D	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0002094	molecular_function	polyprenyltransferase activity
E	0004659	molecular_function	prenyltransferase activity
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0008834	molecular_function	di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
E	0016094	biological_process	polyprenol biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
E	0030145	molecular_function	manganese ion binding
E	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0002094	molecular_function	polyprenyltransferase activity
F	0004659	molecular_function	prenyltransferase activity
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0008834	molecular_function	di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
F	0016094	biological_process	polyprenol biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
F	0030145	molecular_function	manganese ion binding
F	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 301

Chain	Residue
A	THR191
A	GLU192
A	ALA193
A	HOH476
B	ARG130
D	SER186
D	ARG189
D	HOH416

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 A 302

Chain	Residue
A	GLY45
A	ASN46
A	GLY47
A	ARG57
A	HIS61
A	ARG95
A	HOH430
A	ASP44

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 B 301

Chain	Residue
B	ASP44
B	GLY45
B	ASN46
B	GLY47
B	ARG57
B	HIS61
B	ARG95
B	HOH457

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 B 302

Chain	Residue
A	TYR229
A	ARG260
A	TYR261
A	GLY262
A	HOH455
B	ARG212
B	ARG218
B	SER220
B	HOH455

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 B 303

Chain	Residue
A	ARG184
B	ARG112
B	ARG115
B	GLU141
B	GLU144

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 B 304

Chain	Residue
A	SER186
A	ASN188
A	ARG189
B	HIS119
B	HIS151
B	HOH446

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 C 301

Chain	Residue
C	GLY45
C	ASN46
C	GLY47
C	ARG57
C	HIS61
C	ARG95
C	HOH412

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG212
C	ARG218
C	SER220

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 D 301

Chain	Residue
D	ASP44
D	GLY45
D	ASN46
D	GLY47

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 D 302

Chain	Residue
D	ARG212
D	ARG218
D	SER220

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 E 301

Chain	Residue
E	MET43
E	ASP44
E	GLY45
E	ASN46
E	GLY47
E	HIS61
E	ARG95
E	HOH406

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 E 302

Chain	Residue
E	ARG212
E	ARG218
E	SER220

site_id	AD4
Number of Residues	7
Details	binding site for residue SO4 F 301

Chain	Residue
F	ASP44
F	GLY45
F	ASN46
F	GLY47
F	ARG57
F	ARG95
F	HOH401

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 F 302

Chain	Residue
E	TYR229
F	ARG212
F	ARG218
F	SER220

Functional Information from PROSITE/UniProt

site_id	PS01066
Number of Residues	18
Details	UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLFIRSSGeqRlSnFLLW

Chain	Residue	Details
A	ASP208-TRP225

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	ASP44
B	ASP44
C	ASP44
D	ASP44
E	ASP44
F	ASP44

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	ASN92
B	ASN92
C	ASN92
D	ASN92
E	ASN92
F	ASN92

site_id	SWS_FT_FI3
Number of Residues	66
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP44
A	ARG218
A	GLU231
B	ASP44
B	GLY45
B	TRP49
B	ARG57
B	HIS61
B	SER89
B	TRP93
B	ARG95
A	GLY45
B	ARG212
B	ARG218
B	GLU231
C	ASP44
C	GLY45
C	TRP49
C	ARG57
C	HIS61
C	SER89
C	TRP93
A	TRP49
C	ARG95
C	ARG212
C	ARG218
C	GLU231
D	ASP44
D	GLY45
D	TRP49
D	ARG57
D	HIS61
D	SER89
A	ARG57
D	TRP93
D	ARG95
D	ARG212
D	ARG218
D	GLU231
E	ASP44
E	GLY45
E	TRP49
E	ARG57
E	HIS61
A	HIS61
E	SER89
E	TRP93
E	ARG95
E	ARG212
E	ARG218
E	GLU231
F	ASP44
F	GLY45
F	TRP49
F	ARG57
A	SER89
F	HIS61
F	SER89
F	TRP93
F	ARG95
F	ARG212
F	ARG218
F	GLU231
A	TRP93
A	ARG95
A	ARG212

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)