7CI5
Crystal structure of P.aeruginosa LpxC in complex with inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006796 | biological_process | phosphate-containing compound metabolic process |
A | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
A | 0009245 | biological_process | lipid A biosynthetic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019637 | biological_process | organophosphate metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
A | 1901135 | biological_process | carbohydrate derivative metabolic process |
B | 0006796 | biological_process | phosphate-containing compound metabolic process |
B | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
B | 0009245 | biological_process | lipid A biosynthetic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0019637 | biological_process | organophosphate metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
B | 1901135 | biological_process | carbohydrate derivative metabolic process |
C | 0006796 | biological_process | phosphate-containing compound metabolic process |
C | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
C | 0009245 | biological_process | lipid A biosynthetic process |
C | 0016787 | molecular_function | hydrolase activity |
C | 0019637 | biological_process | organophosphate metabolic process |
C | 0046872 | molecular_function | metal ion binding |
C | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
C | 1901135 | biological_process | carbohydrate derivative metabolic process |
D | 0006796 | biological_process | phosphate-containing compound metabolic process |
D | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
D | 0009245 | biological_process | lipid A biosynthetic process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0019637 | biological_process | organophosphate metabolic process |
D | 0046872 | molecular_function | metal ion binding |
D | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
D | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue FXX A 301 |
Chain | Residue |
A | LEU18 |
A | LYS238 |
A | ASP241 |
A | HIS264 |
A | ZN303 |
A | HOH415 |
A | MET62 |
A | GLU77 |
A | HIS78 |
A | ILE197 |
A | GLY209 |
A | ASN213 |
A | ALA214 |
A | HIS237 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue MPO A 302 |
Chain | Residue |
A | ARG41 |
A | ASP70 |
A | LYS72 |
A | SER98 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN A 303 |
Chain | Residue |
A | HIS78 |
A | HIS237 |
A | ASP241 |
A | FXX301 |
site_id | AC4 |
Number of Residues | 14 |
Details | binding site for residue FXX B 301 |
Chain | Residue |
B | LEU18 |
B | MET62 |
B | GLU77 |
B | HIS78 |
B | ILE102 |
B | ILE197 |
B | GLY209 |
B | ASN213 |
B | ALA214 |
B | HIS237 |
B | LYS238 |
B | ASP241 |
B | HIS264 |
B | ZN303 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue MPO B 302 |
Chain | Residue |
B | ARG41 |
B | ASP70 |
B | LYS72 |
B | SER98 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ZN B 303 |
Chain | Residue |
B | HIS78 |
B | HIS237 |
B | ASP241 |
B | FXX301 |
site_id | AC7 |
Number of Residues | 12 |
Details | binding site for residue FXX C 301 |
Chain | Residue |
C | LEU18 |
C | MET62 |
C | GLU77 |
C | HIS78 |
C | ILE197 |
C | ASN213 |
C | ALA214 |
C | HIS237 |
C | LYS238 |
C | ASP241 |
C | HIS264 |
C | ZN303 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue MPO C 302 |
Chain | Residue |
C | ARG41 |
C | ASP70 |
C | VAL71 |
C | LYS72 |
C | SER98 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue ZN C 303 |
Chain | Residue |
C | HIS78 |
C | HIS237 |
C | ASP241 |
C | FXX301 |
site_id | AD1 |
Number of Residues | 13 |
Details | binding site for residue FXX D 301 |
Chain | Residue |
D | LEU18 |
D | MET62 |
D | GLU77 |
D | HIS78 |
D | THR190 |
D | ILE197 |
D | GLY209 |
D | ASN213 |
D | HIS237 |
D | LYS238 |
D | ASP241 |
D | HIS264 |
D | ZN303 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue MPO D 302 |
Chain | Residue |
D | ARG41 |
D | ASP70 |
D | VAL71 |
D | LYS72 |
D | SER98 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue ZN D 303 |
Chain | Residue |
D | HIS78 |
D | HIS237 |
D | ASP241 |
D | FXX301 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00388 |
Chain | Residue | Details |
B | HIS264 | |
C | HIS264 | |
D | HIS264 | |
A | HIS264 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00388 |
Chain | Residue | Details |
C | ASP241 | |
D | HIS78 | |
D | HIS237 | |
D | ASP241 | |
A | ASP241 | |
B | HIS78 | |
B | HIS237 | |
B | ASP241 | |
C | HIS78 | |
C | HIS237 | |
A | HIS78 | |
A | HIS237 |