7CI4
Crystal structure of P.aeruginosa LpxC in complex with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006796 | biological_process | phosphate-containing compound metabolic process |
| A | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019637 | biological_process | organophosphate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0006796 | biological_process | phosphate-containing compound metabolic process |
| B | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019637 | biological_process | organophosphate metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue FXU A 1300 |
| Chain | Residue |
| A | LEU18 |
| A | HIS237 |
| A | LYS238 |
| A | ASP241 |
| A | HIS264 |
| A | ZN1301 |
| A | HOH1452 |
| A | HOH1560 |
| A | MET62 |
| A | GLU77 |
| A | HIS78 |
| A | THR190 |
| A | GLY192 |
| A | ILE197 |
| A | ASN213 |
| A | ALA214 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1301 |
| Chain | Residue |
| A | HIS78 |
| A | HIS237 |
| A | ASP241 |
| A | FXU1300 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1302 |
| Chain | Residue |
| A | ASP277 |
| A | ASP279 |
| A | HOH1414 |
| A | HOH1432 |
| A | HOH1530 |
| B | HOH1440 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1303 |
| Chain | Residue |
| A | ARG143 |
| A | ARG258 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue FXU B 1300 |
| Chain | Residue |
| B | LEU18 |
| B | MET62 |
| B | GLU77 |
| B | HIS78 |
| B | THR190 |
| B | ILE197 |
| B | ASN213 |
| B | ALA214 |
| B | HIS237 |
| B | LYS238 |
| B | ASP241 |
| B | HIS264 |
| B | ZN1301 |
| B | HOH1467 |
| B | HOH1502 |
| B | HOH1506 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1301 |
| Chain | Residue |
| B | HIS78 |
| B | HIS237 |
| B | ASP241 |
| B | FXU1300 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1302 |
| Chain | Residue |
| A | HOH1446 |
| A | HOH1509 |
| B | ASP277 |
| B | ASP279 |
| B | HOH1410 |
| B | HOH1425 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 1303 |
| Chain | Residue |
| B | ARG41 |
| B | HOH1537 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00388 |
| Chain | Residue | Details |
| A | HIS264 | |
| B | HIS264 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00388 |
| Chain | Residue | Details |
| A | HIS78 | |
| A | HIS237 | |
| A | ASP241 | |
| B | HIS78 | |
| B | HIS237 | |
| B | ASP241 |
