Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CGA

Crystal structure of human unphosphorylated p38gamma

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0007517	biological_process	muscle organ development
A	0016301	molecular_function	kinase activity
A	0016504	molecular_function	peptidase activator activity
A	0016740	molecular_function	transferase activity
A	0033554	biological_process	cellular response to stress
A	0035556	biological_process	intracellular signal transduction
A	0042770	biological_process	signal transduction in response to DNA damage
A	0045445	biological_process	myoblast differentiation
A	0045786	biological_process	negative regulation of cell cycle
A	0046872	molecular_function	metal ion binding
A	0051149	biological_process	positive regulation of muscle cell differentiation
A	0051726	biological_process	regulation of cell cycle
A	0106310	molecular_function	protein serine kinase activity
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004707	molecular_function	MAP kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006468	biological_process	protein phosphorylation
B	0007165	biological_process	signal transduction
B	0007517	biological_process	muscle organ development
B	0016301	molecular_function	kinase activity
B	0016504	molecular_function	peptidase activator activity
B	0016740	molecular_function	transferase activity
B	0033554	biological_process	cellular response to stress
B	0035556	biological_process	intracellular signal transduction
B	0042770	biological_process	signal transduction in response to DNA damage
B	0045445	biological_process	myoblast differentiation
B	0045786	biological_process	negative regulation of cell cycle
B	0046872	molecular_function	metal ion binding
B	0051149	biological_process	positive regulation of muscle cell differentiation
B	0051726	biological_process	regulation of cell cycle
B	0106310	molecular_function	protein serine kinase activity
C	0000165	biological_process	MAPK cascade
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004707	molecular_function	MAP kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006468	biological_process	protein phosphorylation
C	0007165	biological_process	signal transduction
C	0007517	biological_process	muscle organ development
C	0016301	molecular_function	kinase activity
C	0016504	molecular_function	peptidase activator activity
C	0016740	molecular_function	transferase activity
C	0033554	biological_process	cellular response to stress
C	0035556	biological_process	intracellular signal transduction
C	0042770	biological_process	signal transduction in response to DNA damage
C	0045445	biological_process	myoblast differentiation
C	0045786	biological_process	negative regulation of cell cycle
C	0046872	molecular_function	metal ion binding
C	0051149	biological_process	positive regulation of muscle cell differentiation
C	0051726	biological_process	regulation of cell cycle
C	0106310	molecular_function	protein serine kinase activity
D	0000165	biological_process	MAPK cascade
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004707	molecular_function	MAP kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006351	biological_process	DNA-templated transcription
D	0006468	biological_process	protein phosphorylation
D	0007165	biological_process	signal transduction
D	0007517	biological_process	muscle organ development
D	0016301	molecular_function	kinase activity
D	0016504	molecular_function	peptidase activator activity
D	0016740	molecular_function	transferase activity
D	0033554	biological_process	cellular response to stress
D	0035556	biological_process	intracellular signal transduction
D	0042770	biological_process	signal transduction in response to DNA damage
D	0045445	biological_process	myoblast differentiation
D	0045786	biological_process	negative regulation of cell cycle
D	0046872	molecular_function	metal ion binding
D	0051149	biological_process	positive regulation of muscle cell differentiation
D	0051726	biological_process	regulation of cell cycle
D	0106310	molecular_function	protein serine kinase activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGAVCsAvdgrtgakv.........AIKK

Chain	Residue	Details
A	VAL33-LYS57

site_id	PS01351
Number of Residues	104
Details	MAPK MAP kinase signature. FqselfakrayRElrllkhmrhenviglldvftpdetlddftdfylvmpfmgtdlgklmkheklgedriqflvyqmlkglryihaagiih.........RDlKpgnlavnedC

Chain	Residue	Details
A	PHE62-CYS165

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1136
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K3 and MAP2K6","evidences":[{"source":"UniProtKB","id":"Q63538","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)