Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CE9

PQQ-soaked Apo-methanol dehydrogenase (MDH) from Methylococcus capsulatus (Bath)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005509	molecular_function	calcium ion binding
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0020037	molecular_function	heme binding
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0046872	molecular_function	metal ion binding
A	0070968	molecular_function	pyrroloquinoline quinone binding
B	0003824	molecular_function	catalytic activity
B	0005509	molecular_function	calcium ion binding
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0020037	molecular_function	heme binding
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0046872	molecular_function	metal ion binding
B	0070968	molecular_function	pyrroloquinoline quinone binding
C	0003824	molecular_function	catalytic activity
C	0005509	molecular_function	calcium ion binding
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0020037	molecular_function	heme binding
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0046872	molecular_function	metal ion binding
C	0070968	molecular_function	pyrroloquinoline quinone binding
D	0003824	molecular_function	catalytic activity
D	0005509	molecular_function	calcium ion binding
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
D	0020037	molecular_function	heme binding
D	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0046872	molecular_function	metal ion binding
D	0070968	molecular_function	pyrroloquinoline quinone binding
E	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
E	0015945	biological_process	methanol metabolic process
E	0015946	biological_process	methanol oxidation
E	0016491	molecular_function	oxidoreductase activity
E	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
F	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
F	0015945	biological_process	methanol metabolic process
F	0015946	biological_process	methanol oxidation
F	0016491	molecular_function	oxidoreductase activity
F	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
G	0003824	molecular_function	catalytic activity
G	0005509	molecular_function	calcium ion binding
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
G	0020037	molecular_function	heme binding
G	0030288	cellular_component	outer membrane-bounded periplasmic space
G	0046872	molecular_function	metal ion binding
G	0070968	molecular_function	pyrroloquinoline quinone binding
H	0003824	molecular_function	catalytic activity
H	0005509	molecular_function	calcium ion binding
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
H	0020037	molecular_function	heme binding
H	0030288	cellular_component	outer membrane-bounded periplasmic space
H	0046872	molecular_function	metal ion binding
H	0070968	molecular_function	pyrroloquinoline quinone binding
I	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
I	0015945	biological_process	methanol metabolic process
I	0015946	biological_process	methanol oxidation
I	0016491	molecular_function	oxidoreductase activity
I	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
J	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
J	0015945	biological_process	methanol metabolic process
J	0015946	biological_process	methanol oxidation
J	0016491	molecular_function	oxidoreductase activity
J	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
K	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
K	0015945	biological_process	methanol metabolic process
K	0015946	biological_process	methanol oxidation
K	0016491	molecular_function	oxidoreductase activity
K	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
L	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
L	0015945	biological_process	methanol metabolic process
L	0015946	biological_process	methanol oxidation
L	0016491	molecular_function	oxidoreductase activity
L	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
M	0003824	molecular_function	catalytic activity
M	0005509	molecular_function	calcium ion binding
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
M	0020037	molecular_function	heme binding
M	0030288	cellular_component	outer membrane-bounded periplasmic space
M	0046872	molecular_function	metal ion binding
M	0070968	molecular_function	pyrroloquinoline quinone binding
N	0003824	molecular_function	catalytic activity
N	0005509	molecular_function	calcium ion binding
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
N	0020037	molecular_function	heme binding
N	0030288	cellular_component	outer membrane-bounded periplasmic space
N	0046872	molecular_function	metal ion binding
N	0070968	molecular_function	pyrroloquinoline quinone binding
O	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
O	0015945	biological_process	methanol metabolic process
O	0015946	biological_process	methanol oxidation
O	0016491	molecular_function	oxidoreductase activity
O	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
P	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
P	0015945	biological_process	methanol metabolic process
P	0015946	biological_process	methanol oxidation
P	0016491	molecular_function	oxidoreductase activity
P	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 701

Chain	Residue
A	GLU205
A	ASN289
A	ASP331
A	PQQ702

site_id	AC2
Number of Residues	24
Details	binding site for residue PQQ A 702

Chain	Residue
A	THR187
A	ALA202
A	GLY203
A	ALA204
A	GLU205
A	THR269
A	TRP271
A	ASN289
A	ASP331
A	ARG358
A	ASN421
A	TRP497
A	GLY560
A	TRP561
A	CA701
A	HOH838
A	HOH852
A	HOH910
A	HOH922
A	GLU83
A	CYS131
A	CYS132
A	VAL135
A	ARG137

site_id	AC3
Number of Residues	4
Details	binding site for residue CA B 701

Chain	Residue
B	GLU205
B	ASN289
B	ASP331
B	PQQ702

site_id	AC4
Number of Residues	24
Details	binding site for residue PQQ B 702

Chain	Residue
B	GLU83
B	CYS131
B	CYS132
B	VAL135
B	ARG137
B	THR187
B	ALA202
B	GLY203
B	ALA204
B	GLU205
B	THR269
B	TRP271
B	ASN289
B	ASP331
B	ARG358
B	ASN421
B	TRP497
B	GLY560
B	TRP561
B	CA701
B	HOH814
B	HOH864
B	HOH876
B	HOH984

site_id	AC5
Number of Residues	4
Details	binding site for residue CA C 701

Chain	Residue
C	GLU205
C	ASN289
C	ASP331
C	PQQ702

site_id	AC6
Number of Residues	24
Details	binding site for residue PQQ C 702

Chain	Residue
C	GLU83
C	CYS131
C	CYS132
C	VAL135
C	ARG137
C	THR187
C	ALA202
C	GLY203
C	ALA204
C	GLU205
C	THR269
C	TRP271
C	ASN289
C	ASP331
C	ARG358
C	ASN421
C	TRP497
C	GLY560
C	TRP561
C	CA701
C	HOH817
C	HOH843
C	HOH910
C	HOH1003

site_id	AC7
Number of Residues	4
Details	binding site for residue CA D 701

Chain	Residue
D	GLU205
D	ASN289
D	ASP331
D	PQQ702

site_id	AC8
Number of Residues	23
Details	binding site for residue PQQ D 702

Chain	Residue
D	TRP271
D	ASN289
D	ASP331
D	ARG358
D	ASN421
D	TRP497
D	GLY560
D	TRP561
D	CA701
D	HOH826
D	HOH884
D	HOH972
D	GLU83
D	CYS131
D	CYS132
D	VAL135
D	ARG137
D	THR187
D	ALA202
D	GLY203
D	ALA204
D	GLU205
D	THR269

site_id	AC9
Number of Residues	4
Details	binding site for residue CA G 701

Chain	Residue
G	GLU205
G	ASN289
G	ASP331
G	PQQ702

site_id	AD1
Number of Residues	24
Details	binding site for residue PQQ G 702

Chain	Residue
G	GLU83
G	CYS131
G	CYS132
G	VAL135
G	ARG137
G	THR187
G	ALA202
G	GLY203
G	ALA204
G	GLU205
G	THR269
G	TRP271
G	ASN289
G	ASP331
G	ARG358
G	ASN421
G	TRP497
G	GLY560
G	TRP561
G	CA701
G	HOH844
G	HOH865
G	HOH900
G	HOH984

site_id	AD2
Number of Residues	4
Details	binding site for residue CA H 701

Chain	Residue
H	GLU205
H	ASN289
H	ASP331
H	PQQ702

site_id	AD3
Number of Residues	22
Details	binding site for residue PQQ H 702

Chain	Residue
H	GLU83
H	CYS132
H	VAL135
H	ARG137
H	THR187
H	ALA202
H	GLY203
H	ALA204
H	GLU205
H	THR269
H	TRP271
H	ASN289
H	ASP331
H	ARG358
H	ASN421
H	TRP497
H	GLY560
H	TRP561
H	CA701
H	HOH805
H	HOH818
H	HOH847

site_id	AD4
Number of Residues	4
Details	binding site for residue CA M 701

Chain	Residue
M	GLU205
M	ASN289
M	ASP331
M	PQQ702

site_id	AD5
Number of Residues	23
Details	binding site for residue PQQ M 702

Chain	Residue
M	GLU83
M	CYS131
M	CYS132
M	VAL135
M	ARG137
M	THR187
M	ALA202
M	GLY203
M	ALA204
M	GLU205
M	THR269
M	TRP271
M	ASN289
M	ASP331
M	ARG358
M	ASN421
M	TRP497
M	GLY560
M	TRP561
M	CA701
M	HOH805
M	HOH841
M	HOH872

site_id	AD6
Number of Residues	4
Details	binding site for residue CA N 701

Chain	Residue
N	GLU205
N	ASN289
N	ASP331
N	PQQ702

site_id	AD7
Number of Residues	24
Details	binding site for residue PQQ N 702

Chain	Residue
N	GLU83
N	CYS131
N	CYS132
N	VAL135
N	ARG137
N	THR187
N	ALA202
N	GLY203
N	ALA204
N	GLU205
N	THR269
N	TRP271
N	ASN289
N	ASP331
N	ARG358
N	ASN421
N	TRP497
N	GLY560
N	TRP561
N	CA701
N	HOH802
N	HOH808
N	HOH817
N	HOH919

Functional Information from PROSITE/UniProt

site_id	PS00364
Number of Residues	22
Details	BACTERIAL_PQQ_2 Bacterial quinoprotein dehydrogenases signature 2. WgwyaYDpklDMIYYgsGnpAP

Chain	Residue	Details
A	TRP271-PRO292

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)