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7CD5

mAPE1-blunt-ended dsDNA product complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000723biological_processtelomere maintenance
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003691molecular_functiondouble-stranded telomeric DNA binding
A0003713molecular_functiontranscription coactivator activity
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
A0004518molecular_functionnuclease activity
A0004519molecular_functionendonuclease activity
A0004521molecular_functionRNA endonuclease activity
A0004527molecular_functionexonuclease activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005813cellular_componentcentrosome
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006308biological_processDNA catabolic process
A0006310biological_processDNA recombination
A0008081molecular_functionphosphoric diester hydrolase activity
A0008296molecular_function3'-5'-DNA exonuclease activity
A0008309molecular_functiondouble-stranded DNA exodeoxyribonuclease activity
A0008311molecular_functiondouble-stranded DNA 3'-5' DNA exonuclease activity
A0008408molecular_function3'-5' exonuclease activity
A0014912biological_processnegative regulation of smooth muscle cell migration
A0016491molecular_functionoxidoreductase activity
A0016607cellular_componentnuclear speck
A0016890molecular_functionsite-specific endodeoxyribonuclease activity, specific for altered base
A0031490molecular_functionchromatin DNA binding
A0042981biological_processregulation of apoptotic process
A0043488biological_processregulation of mRNA stability
A0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
A0044877molecular_functionprotein-containing complex binding
A0045454biological_processcell redox homeostasis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051059molecular_functionNF-kappaB binding
A0052720molecular_functionclass II DNA-(apurinic or apyrimidinic site) endonuclease activity
A0070301biological_processcellular response to hydrogen peroxide
A0090580molecular_functionphosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
A0097698biological_processtelomere maintenance via base-excision repair
A0140431molecular_functionDNA-(abasic site) binding
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00726
Number of Residues10
DetailsAP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. PDILCLQETK
ChainResidueDetails
APRO88-LYS97

site_idPS00727
Number of Residues17
DetailsAP_NUCLEASE_F1_2 AP endonucleases family 1 signature 2. DSFRHlypntayaYTFW
ChainResidueDetails
AASP250-TRP266

site_idPS00728
Number of Residues12
DetailsAP_NUCLEASE_F1_3 AP endonucleases family 1 signature 3. NvGwRLDYfLlS
ChainResidueDetails
AASN276-SER287

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
ATYR170

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000250
ChainResidueDetails
AASP209

site_idSWS_FT_FI3
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASN211
AASP307
AASP69
AGLU95
AASP209

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Cleavage; by granzyme A => ECO:0000250
ChainResidueDetails
ALYS30

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Transition state stabilizer => ECO:0000250
ChainResidueDetails
AASN211

site_idSWS_FT_FI6
Number of Residues1
DetailsSITE: Important for catalytic activity => ECO:0000250
ChainResidueDetails
AASP282

site_idSWS_FT_FI7
Number of Residues1
DetailsSITE: Interaction with DNA substrate => ECO:0000250
ChainResidueDetails
AHIS308

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; by EP300 => ECO:0000250|UniProtKB:P27695
ChainResidueDetails
ALYS7
ALYS6

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER18

site_idSWS_FT_FI10
Number of Residues5
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P27695
ChainResidueDetails
ALYS30
ALYS31
ALYS34
ALYS196
ALYS26

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P27695
ChainResidueDetails
ASER53

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine; alternate => ECO:0000250|UniProtKB:P27695
ChainResidueDetails
ACYS92
ACYS64

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CDK5 => ECO:0000269|PubMed:20473298
ChainResidueDetails
ATHR232

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P27695
ChainResidueDetails
ACYS309

219869

PDB entries from 2024-05-15

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