7CD5
mAPE1-blunt-ended dsDNA product complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000723 | biological_process | telomere maintenance |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0003691 | molecular_function | double-stranded telomeric DNA binding |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003906 | molecular_function | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005813 | cellular_component | centrosome |
| A | 0006281 | biological_process | DNA repair |
| A | 0006284 | biological_process | base-excision repair |
| A | 0006308 | biological_process | DNA catabolic process |
| A | 0006310 | biological_process | DNA recombination |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0008296 | molecular_function | 3'-5'-DNA exonuclease activity |
| A | 0008309 | molecular_function | double-stranded DNA exodeoxyribonuclease activity |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016890 | molecular_function | site-specific endodeoxyribonuclease activity, specific for altered base |
| A | 0031490 | molecular_function | chromatin DNA binding |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043488 | biological_process | regulation of mRNA stability |
| A | 0044029 | biological_process | positive regulation of gene expression via chromosomal CpG island demethylation |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0052720 | molecular_function | class II DNA-(apurinic or apyrimidinic site) endonuclease activity |
| A | 0090580 | molecular_function | phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands |
| A | 0097698 | biological_process | telomere maintenance via base-excision repair |
| A | 0140431 | molecular_function | DNA-(abasic site) binding |
Functional Information from PROSITE/UniProt
| site_id | PS00726 |
| Number of Residues | 10 |
| Details | AP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. PDILCLQETK |
| Chain | Residue | Details |
| A | PRO88-LYS97 |
| site_id | PS00727 |
| Number of Residues | 17 |
| Details | AP_NUCLEASE_F1_2 AP endonucleases family 1 signature 2. DSFRHlypntayaYTFW |
| Chain | Residue | Details |
| A | ASP250-TRP266 |
| site_id | PS00728 |
| Number of Residues | 12 |
| Details | AP_NUCLEASE_F1_3 AP endonucleases family 1 signature 3. NvGwRLDYfLlS |
| Chain | Residue | Details |
| A | ASN276-SER287 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR170 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP209 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP69 | |
| A | GLU95 | |
| A | ASP209 | |
| A | ASN211 | |
| A | ASP307 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by granzyme A => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS30 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN211 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Important for catalytic activity => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP282 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Interaction with DNA substrate => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS308 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; by EP300 => ECO:0000250|UniProtKB:P27695 |
| Chain | Residue | Details |
| A | LYS6 | |
| A | LYS7 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER18 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P27695 |
| Chain | Residue | Details |
| A | LYS26 | |
| A | LYS30 | |
| A | LYS31 | |
| A | LYS34 | |
| A | LYS196 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P27695 |
| Chain | Residue | Details |
| A | SER53 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: S-nitrosocysteine; alternate => ECO:0000250|UniProtKB:P27695 |
| Chain | Residue | Details |
| A | CYS64 | |
| A | CYS92 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CDK5 => ECO:0000269|PubMed:20473298 |
| Chain | Residue | Details |
| A | THR232 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P27695 |
| Chain | Residue | Details |
| A | CYS309 |
