7CCY

Crystal structure of the 2-iodoporphobilinogen-bound holo form of human hydroxymethylbilane synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004418	molecular_function	hydroxymethylbilane synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006779	biological_process	porphyrin-containing compound biosynthetic process
A	0006782	biological_process	protoporphyrinogen IX biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0006784	biological_process	heme A biosynthetic process
A	0006785	biological_process	heme B biosynthetic process
A	0016740	molecular_function	transferase activity
A	0018160	biological_process	peptidyl-pyrromethane cofactor linkage
A	0033014	biological_process	tetrapyrrole biosynthetic process
A	0048034	biological_process	heme O biosynthetic process
C	0004418	molecular_function	hydroxymethylbilane synthase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006779	biological_process	porphyrin-containing compound biosynthetic process
C	0006782	biological_process	protoporphyrinogen IX biosynthetic process
C	0006783	biological_process	heme biosynthetic process
C	0006784	biological_process	heme A biosynthetic process
C	0006785	biological_process	heme B biosynthetic process
C	0016740	molecular_function	transferase activity
C	0018160	biological_process	peptidyl-pyrromethane cofactor linkage
C	0033014	biological_process	tetrapyrrole biosynthetic process
C	0048034	biological_process	heme O biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue DPM A 401

Chain	Residue
A	SER96
A	ARG195
A	GLY218
A	CYS261
A	HOH503
A	HOH504
A	HOH507
A	HOH523
A	LYS98
A	ASP99
A	SER146
A	SER147
A	ARG149
A	ARG150
A	ARG173
A	ALA189

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site_id	AC2
Number of Residues	12
Details	binding site for residue FWL C 401

Chain	Residue
C	ARG26
C	SER28
C	GLN34
C	PHE77
C	SER96
C	ASP99
C	ARG167
C	GLY168
C	ASN169
C	LEU170
C	ARG173
C	DPM402

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site_id	AC3
Number of Residues	18
Details	binding site for Di-peptide DPM C 402 and CYS C 261

Chain	Residue
C	SER96
C	LYS98
C	ASP99
C	THR145
C	SER146
C	SER147
C	ARG149
C	ARG150
C	ARG173
C	LEU188
C	ALA189
C	GLY218
C	GLY260
C	SER262
C	VAL263
C	FWL401
C	HOH509
C	HOH519

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Functional Information from PROSITE/UniProt

site_id	PS00533
Number of Residues	17
Details	PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA

Chain	Residue	Details
A	GLU250-ALA266

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	SER2
C	SER2

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site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER15
A	SER69
A	SER147
C	SER15
C	SER69
C	SER147

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P22907

Chain	Residue	Details
A	LYS74
C	LYS74

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296

Chain	Residue	Details
A	CYS261
C	CYS261

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