7CCX
Crystal structure of the holo form of human hydroxymethylbilane synthase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004418 | molecular_function | hydroxymethylbilane synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0006784 | biological_process | heme A biosynthetic process |
| A | 0006785 | biological_process | heme B biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018160 | biological_process | peptidyl-pyrromethane cofactor linkage |
| A | 0033014 | biological_process | tetrapyrrole biosynthetic process |
| A | 0048034 | biological_process | heme O biosynthetic process |
| C | 0004418 | molecular_function | hydroxymethylbilane synthase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| C | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| C | 0006783 | biological_process | heme biosynthetic process |
| C | 0006784 | biological_process | heme A biosynthetic process |
| C | 0006785 | biological_process | heme B biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0018160 | biological_process | peptidyl-pyrromethane cofactor linkage |
| C | 0033014 | biological_process | tetrapyrrole biosynthetic process |
| C | 0048034 | biological_process | heme O biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue DPM A 401 |
| Chain | Residue |
| A | SER96 |
| A | ALA189 |
| A | ARG195 |
| A | GLN217 |
| A | GLY218 |
| A | CYS261 |
| A | HOH511 |
| A | HOH525 |
| A | HOH534 |
| A | HOH561 |
| A | HOH575 |
| A | LYS98 |
| A | ASP99 |
| A | SER146 |
| A | SER147 |
| A | ARG149 |
| A | ARG150 |
| A | ARG173 |
| A | LEU188 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide DPM C 401 and CYS C 261 |
| Chain | Residue |
| C | SER96 |
| C | LYS98 |
| C | ASP99 |
| C | SER146 |
| C | SER147 |
| C | ARG149 |
| C | ARG150 |
| C | ARG173 |
| C | LEU188 |
| C | ALA189 |
| C | ALA214 |
| C | GLN217 |
| C | GLY218 |
| C | GLY260 |
| C | SER262 |
| C | VAL263 |
| C | HOH501 |
| C | HOH507 |
| C | HOH517 |
| C | HOH534 |
Functional Information from PROSITE/UniProt
| site_id | PS00533 |
| Number of Residues | 17 |
| Details | PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA |
| Chain | Residue | Details |
| A | GLU250-ALA266 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-(dipyrrolylmethanemethyl)cysteine","evidences":[{"source":"PubMed","id":"18936296","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
