7CCS
Consensus mutated xCT-CD98hc complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006865 | biological_process | amino acid transport |
| B | 0003333 | biological_process | amino acid transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006865 | biological_process | amino acid transport |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0009986 | cellular_component | cell surface |
| B | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| B | 0015252 | molecular_function | proton channel activity |
| B | 0015327 | molecular_function | cystine:glutamate antiporter activity |
| B | 0015811 | biological_process | L-cystine transport |
| B | 0015813 | biological_process | L-glutamate transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022840 | molecular_function | leak channel activity |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0031526 | cellular_component | brush border membrane |
| B | 0031528 | cellular_component | microvillus membrane |
| B | 0035752 | biological_process | lysosomal lumen pH elevation |
| B | 0043067 | biological_process | regulation of programmed cell death |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0089718 | biological_process | amino acid import across plasma membrane |
| B | 0097449 | cellular_component | astrocyte projection |
| B | 0110076 | biological_process | negative regulation of ferroptosis |
| B | 0140924 | biological_process | L-kynurenine transmembrane transport |
| B | 0140926 | molecular_function | L-kynurenine transmembrane transporter activity |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 424 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"11121428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19065266","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 80 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 210 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 78 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 14 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7P9U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
