7CCS
Consensus mutated xCT-CD98hc complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003725 | molecular_function | double-stranded RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0006865 | biological_process | amino acid transport |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0009986 | cellular_component | cell surface |
| A | 0015173 | molecular_function | aromatic amino acid transmembrane transporter activity |
| A | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| A | 0015180 | molecular_function | L-alanine transmembrane transporter activity |
| A | 0015190 | molecular_function | L-leucine transmembrane transporter activity |
| A | 0015818 | biological_process | isoleucine transport |
| A | 0015820 | biological_process | L-leucine transport |
| A | 0015821 | biological_process | methionine transport |
| A | 0015823 | biological_process | phenylalanine transport |
| A | 0015824 | biological_process | proline transport |
| A | 0015827 | biological_process | tryptophan transport |
| A | 0015828 | biological_process | tyrosine transport |
| A | 0015829 | biological_process | valine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0042470 | cellular_component | melanosome |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043330 | biological_process | response to exogenous dsRNA |
| A | 0044225 | cellular_component | apical pole of neuron |
| A | 0045202 | cellular_component | synapse |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070161 | cellular_component | anchoring junction |
| A | 0070327 | biological_process | thyroid hormone transport |
| A | 0089718 | biological_process | amino acid import across plasma membrane |
| A | 0140272 | molecular_function | exogenous protein binding |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1902024 | biological_process | L-histidine transport |
| A | 1903801 | biological_process | L-leucine import across plasma membrane |
| A | 1904273 | biological_process | L-alanine import across plasma membrane |
| A | 1990184 | cellular_component | amino acid transport complex |
| B | 0003333 | biological_process | amino acid transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006865 | biological_process | amino acid transport |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0009986 | cellular_component | cell surface |
| B | 0015252 | molecular_function | proton channel activity |
| B | 0015327 | molecular_function | cystine:glutamate antiporter activity |
| B | 0015811 | biological_process | L-cystine transport |
| B | 0015813 | biological_process | L-glutamate transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022840 | molecular_function | leak channel activity |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0031526 | cellular_component | brush border membrane |
| B | 0031528 | cellular_component | microvillus membrane |
| B | 0035752 | biological_process | lysosomal lumen pH elevation |
| B | 0043067 | biological_process | regulation of programmed cell death |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0089718 | biological_process | amino acid import across plasma membrane |
| B | 0097449 | cellular_component | astrocyte projection |
| B | 0110076 | biological_process | negative regulation of ferroptosis |
| B | 0140924 | biological_process | L-kynurenine transmembrane transport |
| B | 0140926 | molecular_function | L-kynurenine transmembrane transporter activity |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19065266","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 210 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 78 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 14 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7P9U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
