Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CCS

Consensus mutated xCT-CD98hc complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001618	molecular_function	virus receptor activity
A	0003723	molecular_function	RNA binding
A	0003725	molecular_function	double-stranded RNA binding
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006816	biological_process	calcium ion transport
A	0006865	biological_process	amino acid transport
A	0009925	cellular_component	basal plasma membrane
A	0009986	cellular_component	cell surface
A	0015173	molecular_function	aromatic amino acid transmembrane transporter activity
A	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
A	0015180	molecular_function	L-alanine transmembrane transporter activity
A	0015190	molecular_function	L-leucine transmembrane transporter activity
A	0015818	biological_process	isoleucine transport
A	0015820	biological_process	L-leucine transport
A	0015821	biological_process	methionine transport
A	0015823	biological_process	phenylalanine transport
A	0015824	biological_process	proline transport
A	0015827	biological_process	tryptophan transport
A	0015828	biological_process	tyrosine transport
A	0015829	biological_process	valine transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0042470	cellular_component	melanosome
A	0042803	molecular_function	protein homodimerization activity
A	0043025	cellular_component	neuronal cell body
A	0043330	biological_process	response to exogenous dsRNA
A	0044225	cellular_component	apical pole of neuron
A	0045202	cellular_component	synapse
A	0045296	molecular_function	cadherin binding
A	0046718	biological_process	symbiont entry into host cell
A	0046982	molecular_function	protein heterodimerization activity
A	0070062	cellular_component	extracellular exosome
A	0070161	cellular_component	anchoring junction
A	0070327	biological_process	thyroid hormone transport
A	0140272	molecular_function	exogenous protein binding
A	1902024	biological_process	L-histidine transport
A	1903801	biological_process	L-leucine import across plasma membrane
A	1904273	biological_process	L-alanine import across plasma membrane
A	1990184	cellular_component	amino acid transport complex
B	0003333	biological_process	amino acid transmembrane transport
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005886	cellular_component	plasma membrane
B	0006749	biological_process	glutathione metabolic process
B	0006865	biological_process	amino acid transport
B	0007420	biological_process	brain development
B	0008542	biological_process	visual learning
B	0009636	biological_process	response to toxic substance
B	0009986	cellular_component	cell surface
B	0015179	molecular_function	L-amino acid transmembrane transporter activity
B	0015252	molecular_function	proton channel activity
B	0015327	molecular_function	cystine:glutamate antiporter activity
B	0015811	biological_process	L-cystine transport
B	0015813	biological_process	L-glutamate transmembrane transport
B	0016020	cellular_component	membrane
B	0021591	biological_process	ventricular system development
B	0021756	biological_process	striatum development
B	0022840	molecular_function	leak channel activity
B	0022857	molecular_function	transmembrane transporter activity
B	0030534	biological_process	adult behavior
B	0031526	cellular_component	brush border membrane
B	0031528	cellular_component	microvillus membrane
B	0033029	biological_process	regulation of neutrophil apoptotic process
B	0033554	biological_process	cellular response to stress
B	0034599	biological_process	cellular response to oxidative stress
B	0034775	biological_process	glutathione transmembrane transport
B	0035752	biological_process	lysosomal lumen pH elevation
B	0042127	biological_process	regulation of cell population proliferation
B	0043067	biological_process	regulation of programmed cell death
B	0045177	cellular_component	apical part of cell
B	0048021	biological_process	regulation of melanin biosynthetic process
B	0048286	biological_process	lung alveolus development
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0050807	biological_process	regulation of synapse organization
B	0051223	biological_process	regulation of protein transport
B	0051775	biological_process	response to redox state
B	0055085	biological_process	transmembrane transport
B	0060173	biological_process	limb development
B	0070527	biological_process	platelet aggregation
B	0090461	biological_process	intracellular glutamate homeostasis
B	0097449	cellular_component	astrocyte projection
B	0098712	biological_process	L-glutamate import across plasma membrane
B	0110076	biological_process	negative regulation of ferroptosis
B	0140206	biological_process	dipeptide import across plasma membrane
B	0140924	biological_process	L-kynurenine transmembrane transport
B	0140926	molecular_function	L-kynurenine transmembrane transporter activity
B	1900407	biological_process	regulation of cellular response to oxidative stress
B	1901494	biological_process	regulation of cysteine metabolic process
B	1902600	biological_process	proton transmembrane transport
B	1903786	biological_process	regulation of glutathione biosynthetic process
B	1904717	biological_process	regulation of AMPA glutamate receptor clustering
B	2000211	biological_process	regulation of glutamate metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	424
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"11121428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19065266","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	80
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	210
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	78
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	14
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"15151999","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7P9U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)