7CBE
Crystal structure of Homoserine O-succinyltransferase from Escherichia coli K-12
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008899 | molecular_function | homoserine O-succinyltransferase activity |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0019281 | biological_process | L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008899 | molecular_function | homoserine O-succinyltransferase activity |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0019281 | biological_process | L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | HIS174 |
| A | PRO175 |
| A | HIS176 |
| A | ALA177 |
| A | HOH520 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| B | GLU18 |
| B | VAL20 |
| B | ARG181 |
| B | HOH525 |
| A | ARG56 |
| A | ASN60 |
| A | HOH510 |
| A | HOH532 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| B | LEU110 |
| B | GLY111 |
| B | ARG193 |
| B | TYR194 |
| B | ALA195 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | ASN116 |
| B | HIS174 |
| B | PRO175 |
| B | HIS176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000255|HAMAP-Rule:MF_00295, ECO:0000305|PubMed:10572016, ECO:0000305|PubMed:17302437, ECO:0000305|PubMed:17442255 |
| Chain | Residue | Details |
| A | CYS142 | |
| B | CYS142 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00295, ECO:0000305|PubMed:17302437, ECO:0000305|PubMed:17442255 |
| Chain | Residue | Details |
| A | HIS235 | |
| B | HIS235 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00295, ECO:0000305|PubMed:17302437, ECO:0000305|PubMed:17442255 |
| Chain | Residue | Details |
| A | GLU237 | |
| B | GLU237 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00295 |
| Chain | Residue | Details |
| A | LYS163 | |
| A | SER192 | |
| A | ARG249 | |
| B | LYS163 | |
| B | SER192 | |
| B | ARG249 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Important for acyl-CoA specificity => ECO:0000255|HAMAP-Rule:MF_00295 |
| Chain | Residue | Details |
| A | GLY111 | |
| B | GLY111 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_00295 |
| Chain | Residue | Details |
| A | SER192 | |
| B | SER192 |
