7C7L
Cryo-EM structure of the Cas12f1-sgRNA-target DNA complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051607 | biological_process | defense response to virus |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051607 | biological_process | defense response to virus |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:30337455, ECO:0000305|PubMed:32246713, ECO:0000305|PubMed:33333018 |
| Chain | Residue | Details |
| A | ALA326 | |
| A | ASP510 | |
| B | ALA326 | |
| B | ASP510 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:30337455, ECO:0000305|PubMed:33333018 |
| Chain | Residue | Details |
| A | GLU422 | |
| B | GLU422 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:30337455 |
| Chain | Residue | Details |
| A | ARG490 | |
| B | ARG490 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33333018, ECO:0000312|PDB:7C7L |
| Chain | Residue | Details |
| A | CYS50 | |
| B | HIS53 | |
| B | CYS69 | |
| B | CYS72 | |
| B | CYS475 | |
| B | CYS478 | |
| B | CYS500 | |
| B | CYS503 | |
| A | HIS53 | |
| A | CYS69 | |
| A | CYS72 | |
| A | CYS475 | |
| A | CYS478 | |
| A | CYS500 | |
| A | CYS503 | |
| B | CYS50 |
