7C5F

Crystal Structure of Glyceraldehyde-3-phosphate dehydrogenase1 from Escherichia coli at 1.88 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0006006	biological_process	glucose metabolic process
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0006006	biological_process	glucose metabolic process
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding
Q	0006006	biological_process	glucose metabolic process
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0050661	molecular_function	NADP binding
Q	0051287	molecular_function	NAD binding
R	0006006	biological_process	glucose metabolic process
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0050661	molecular_function	NADP binding
R	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue NAD O 401

Chain	Residue
O	ASN7
O	LYS78
O	CYS96
O	THR97
O	GLY98
O	PHE99
O	SER120
O	ALA121
O	CYS150
O	THR180
O	ASN315
O	GLY8
O	PHE319
O	HOH502
O	HOH504
O	HOH511
O	HOH516
O	HOH522
O	HOH529
O	HOH580
O	HOH582
O	HOH587
O	PHE9
O	HOH601
O	HOH605
O	HOH630
O	GLY10
O	ARG11
O	ILE12
O	ASN33
O	ASP34
O	LEU35

---

site_id	AC2
Number of Residues	8
Details	binding site for residue PO4 O 402

Chain	Residue
O	ALA201
O	HOH572
O	HOH584
O	HOH590
P	ALA201
Q	ALA201
R	ALA201
R	HOH529

---

site_id	AC3
Number of Residues	32
Details	binding site for residue NAD P 401

Chain	Residue
P	ASN7
P	GLY8
P	PHE9
P	GLY10
P	ARG11
P	ILE12
P	ASN33
P	ASP34
P	LEU35
P	LYS78
P	CYS96
P	THR97
P	GLY98
P	PHE99
P	SER120
P	ALA121
P	CYS150
P	THR180
P	ASN315
P	PHE319
P	HOH502
P	HOH504
P	HOH505
P	HOH514
P	HOH535
P	HOH551
P	HOH555
P	HOH574
P	HOH591
P	HOH595
P	HOH600
P	HOH620

---

site_id	AC4
Number of Residues	29
Details	binding site for residue NAD Q 401

Chain	Residue
Q	HOH610
Q	HOH618
Q	ASN7
Q	GLY8
Q	GLY10
Q	ARG11
Q	ILE12
Q	ASN33
Q	ASP34
Q	LYS78
Q	CYS96
Q	THR97
Q	GLY98
Q	PHE99
Q	SER120
Q	ALA121
Q	CYS150
Q	THR180
Q	ASN315
Q	PHE319
Q	HOH521
Q	HOH527
Q	HOH530
Q	HOH532
Q	HOH549
Q	HOH563
Q	HOH575
Q	HOH577
Q	HOH594

---

site_id	AC5
Number of Residues	25
Details	binding site for residue NAD R 401

Chain	Residue
R	GLY8
R	PHE9
R	GLY10
R	ARG11
R	ILE12
R	ASP34
R	LEU35
R	LYS78
R	CYS96
R	THR97
R	GLY98
R	PHE99
R	SER120
R	ALA121
R	CYS150
R	THR180
R	ASN315
R	PHE319
R	HOH502
R	HOH508
R	HOH523
R	HOH527
R	HOH540
R	HOH552
R	HOH566

---

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
O	ALA148-LEU155

---

site_id	PS00430
Number of Residues	89
Details	TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. hhhhhhssglvprgshmasmskvgingfgrigrlvlrrllevksnidvvaindltspkilayllkhdsnygpfpwsvdfte..................................DSLIVDGK

Chain	Residue	Details
O	HIS-18-LYS70

---