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7C3K

Crystal Structure of mIRGB10

Functional Information from GO Data
ChainGOidnamespacecontents
A0003925molecular_functionG protein activity
A0005525molecular_functionGTP binding
A0009617biological_processresponse to bacterium
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031640biological_processkilling of cells of another organism
A0042742biological_processdefense response to bacterium
A0042832biological_processdefense response to protozoan
A0045087biological_processinnate immune response
A0050832biological_processdefense response to fungus
A0051260biological_processprotein homooligomerization
A0051607biological_processdefense response to virus
A0051673biological_processdisruption of plasma membrane integrity in another organism
A0106139cellular_componentsymbiont cell surface
A0140639biological_processpositive regulation of pyroptotic inflammatory response
A0140912molecular_functionmembrane destabilizing activity
A0140973biological_processpositive regulation of AIM2 inflammasome complex assembly
A1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
B0003925molecular_functionG protein activity
B0005525molecular_functionGTP binding
B0009617biological_processresponse to bacterium
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031640biological_processkilling of cells of another organism
B0042742biological_processdefense response to bacterium
B0042832biological_processdefense response to protozoan
B0045087biological_processinnate immune response
B0050832biological_processdefense response to fungus
B0051260biological_processprotein homooligomerization
B0051607biological_processdefense response to virus
B0051673biological_processdisruption of plasma membrane integrity in another organism
B0106139cellular_componentsymbiont cell surface
B0140639biological_processpositive regulation of pyroptotic inflammatory response
B0140912molecular_functionmembrane destabilizing activity
B0140973biological_processpositive regulation of AIM2 inflammasome complex assembly
B1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue GDP A 500
ChainResidue
ATHR77
AASP185
ASER230
ASER231
APHE232
AGLY78
AALA79
AGLY80
ALYS81
ASER82
ATHR83
ASER101
ALYS183

site_idAC2
Number of Residues14
Detailsbinding site for residue GDP B 500
ChainResidue
BTHR77
BGLY78
BALA79
BGLY80
BLYS81
BSER82
BTHR83
BSER101
BLYS183
BASP185
BSER186
BSER230
BSER231
BPHE232

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues70
DetailsTRANSMEM: Helical => ECO:0000305|PubMed:27693356
ChainResidueDetails
AGLU284-ASP302
AALA370-TYR387
BGLU284-ASP302
BALA370-TYR387

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:33469160, ECO:0007744|PDB:7C3K
ChainResidueDetails
AGLY78
BALA79
BSER82
BTHR83
BSER101
BLYS183
BASP185
BSER231
AALA79
ASER82
ATHR83
ASER101
ALYS183
AASP185
ASER231
BGLY78

site_idSWS_FT_FI3
Number of Residues2
DetailsLIPID: N-myristoyl glycine => ECO:0000305|PubMed:23785284
ChainResidueDetails
AGLY2
BGLY2

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PDB entries from 2024-07-24

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