7C3K

Crystal Structure of mIRGB10

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000166	molecular_function	nucleotide binding
A	0002376	biological_process	immune system process
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005525	molecular_function	GTP binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0009617	biological_process	response to bacterium
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031640	biological_process	killing of cells of another organism
A	0035458	biological_process	cellular response to interferon-beta
A	0042742	biological_process	defense response to bacterium
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0050832	biological_process	defense response to fungus
A	0051260	biological_process	protein homooligomerization
A	0051607	biological_process	defense response to virus
A	0051673	biological_process	disruption of plasma membrane integrity in another organism
A	0106139	cellular_component	symbiont cell surface
A	0140639	biological_process	positive regulation of pyroptotic inflammatory response
A	0140912	molecular_function	membrane destabilizing activity
A	0140970	biological_process	AIM2 inflammasome complex assembly
A	0140973	biological_process	positive regulation of AIM2 inflammasome complex assembly
A	0160075	biological_process	non-canonical inflammasome complex assembly
A	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
B	0000045	biological_process	autophagosome assembly
B	0000166	molecular_function	nucleotide binding
B	0002376	biological_process	immune system process
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005525	molecular_function	GTP binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0009617	biological_process	response to bacterium
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031640	biological_process	killing of cells of another organism
B	0035458	biological_process	cellular response to interferon-beta
B	0042742	biological_process	defense response to bacterium
B	0042832	biological_process	defense response to protozoan
B	0045087	biological_process	innate immune response
B	0050832	biological_process	defense response to fungus
B	0051260	biological_process	protein homooligomerization
B	0051607	biological_process	defense response to virus
B	0051673	biological_process	disruption of plasma membrane integrity in another organism
B	0106139	cellular_component	symbiont cell surface
B	0140639	biological_process	positive regulation of pyroptotic inflammatory response
B	0140912	molecular_function	membrane destabilizing activity
B	0140970	biological_process	AIM2 inflammasome complex assembly
B	0140973	biological_process	positive regulation of AIM2 inflammasome complex assembly
B	0160075	biological_process	non-canonical inflammasome complex assembly
B	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GDP A 500

Chain	Residue
A	THR77
A	ASP185
A	SER230
A	SER231
A	PHE232
A	GLY78
A	ALA79
A	GLY80
A	LYS81
A	SER82
A	THR83
A	SER101
A	LYS183

---

site_id	AC2
Number of Residues	14
Details	binding site for residue GDP B 500

Chain	Residue
B	THR77
B	GLY78
B	ALA79
B	GLY80
B	LYS81
B	SER82
B	THR83
B	SER101
B	LYS183
B	ASP185
B	SER186
B	SER230
B	SER231
B	PHE232

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27693356","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33469160","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7C3K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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