7C2N

Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with SPIRO

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016998	biological_process	cell wall macromolecule catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue L6T A 1001

Chain	Residue
A	GLU46
A	PHE240
A	SER54
A	LEU55
A	ASP58
A	ARG63
A	ASP64
A	ASP144
A	LEU171
A	HIS239

---

site_id	AC2
Number of Residues	5
Details	binding site for residue L6T A 1002

Chain	Residue
A	VAL109
A	THR121
A	VAL122
A	MET125
A	ARG453

---

site_id	AC3
Number of Residues	9
Details	binding site for residue L6T A 1003

Chain	Residue
A	GLN-3
A	ARG288
A	VAL291
A	PHE292
A	LEU581
A	SER652
A	ARG653
A	GLU656
A	ARG744

---

site_id	AC4
Number of Residues	7
Details	binding site for residue L6T A 1004

Chain	Residue
A	TRP609
A	HIS615
A	GLY618
A	LEU619
A	LEU713
A	LYS884
A	MHA1007

---

site_id	AC5
Number of Residues	4
Details	binding site for residue L6T A 1005

Chain	Residue
A	ARG188
A	ALA192
A	ASN621
A	ALA692

---

site_id	AC6
Number of Residues	7
Details	binding site for residue MHA A 1006

Chain	Residue
A	ASP759
A	THR891
A	ASN893
A	ARG894
A	ILE917
A	LYS918
A	ALA919

---

site_id	AC7
Number of Residues	7
Details	binding site for residue MHA A 1007

Chain	Residue
A	GLY862
A	PHE863
A	THR864
A	ASN865
A	SER866
A	ASN881
A	L6T1004

---

site_id	AC8
Number of Residues	11
Details	binding site for residue FG0 A 1008

Chain	Residue
A	ILE249
A	ILE253
A	PHE260
A	SER293
A	ILE297
A	VAL638
A	GLY641
A	LEU642
A	ASP645
A	TYR646
A	PHE649

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	69
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	330
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	28
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	19
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OR2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AJG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Site: {"description":"Part of the proton-transportation channel","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Part of the proton transportation network","evidences":[{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Site: {"description":"Part of the proton-transportation channel","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32512002","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---