7BXO

Crystal structure of the toxin-antitoxin with AMP-PNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0070733	molecular_function	AMPylase activity
B	0004540	molecular_function	RNA nuclease activity
B	0110001	cellular_component	toxin-antitoxin complex
C	0004540	molecular_function	RNA nuclease activity
C	0110001	cellular_component	toxin-antitoxin complex
D	0004540	molecular_function	RNA nuclease activity
D	0110001	cellular_component	toxin-antitoxin complex
E	0070733	molecular_function	AMPylase activity
F	0004540	molecular_function	RNA nuclease activity
F	0110001	cellular_component	toxin-antitoxin complex
G	0004540	molecular_function	RNA nuclease activity
G	0110001	cellular_component	toxin-antitoxin complex
H	0004540	molecular_function	RNA nuclease activity
H	0110001	cellular_component	toxin-antitoxin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ANP A 201

Chain	Residue
A	PHE26
A	MG203
H	ASN7
H	LYS8
A	GLY27
A	SER28
A	HIS35
A	SER38
A	ASP39
A	ASP41
A	GLN85
A	MG202

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 202

Chain	Residue
A	ASP39
A	ASP41
A	ANP201

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 203

Chain	Residue
A	ASP39
A	ASP41
A	ASP71
A	ANP201

---

site_id	AC4
Number of Residues	18
Details	binding site for residue ANP E 201

Chain	Residue
D	ASN7
D	LYS8
D	ARG59
E	PHE26
E	GLY27
E	SER28
E	HIS35
E	SER38
E	ASP39
E	ASP41
E	GLN85
E	GLN89
E	MG202
E	MG203
E	HOH303
E	HOH304
H	ASP103
H	ALA104

---

site_id	AC5
Number of Residues	3
Details	binding site for residue MG E 202

Chain	Residue
E	ASP39
E	ASP41
E	ANP201

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG E 203

Chain	Residue
E	ASP39
E	ASP41
E	ASP71
E	ANP201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Motif: {"description":"GSX(10)DXD motif","evidences":[{"source":"PubMed","id":"33045733","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33045733","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7BXO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Motif: {"description":"RX(4)HXY motif","evidences":[{"source":"PubMed","id":"26112399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33045733","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"A0A0B0QJR1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"O-tri-AMP-tyrosine","evidences":[{"source":"PubMed","id":"33045733","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33290744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AER","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---