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7BV4

Crystal structure of STX17 LIR region in complex with GABARAP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000226biological_processmicrotubule cytoskeleton organization
A0000421cellular_componentautophagosome membrane
A0000422biological_processautophagy of mitochondrion
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005776cellular_componentautophagosome
A0005790cellular_componentsmooth endoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005875cellular_componentmicrotubule associated complex
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0006605biological_processprotein targeting
A0006914biological_processautophagy
A0006915biological_processapoptotic process
A0006995biological_processcellular response to nitrogen starvation
A0007268biological_processchemical synaptic transmission
A0008017molecular_functionmicrotubule binding
A0008429molecular_functionphosphatidylethanolamine binding
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0012505cellular_componentendomembrane system
A0015031biological_processprotein transport
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0035020biological_processregulation of Rac protein signal transduction
A0048487molecular_functionbeta-tubulin binding
A0050811molecular_functionGABA receptor binding
A0097225cellular_componentsperm midpiece
A0097352biological_processautophagosome maturation
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098982cellular_componentGABA-ergic synapse
A1902524biological_processpositive regulation of protein K48-linked ubiquitination
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000226biological_processmicrotubule cytoskeleton organization
B0000421cellular_componentautophagosome membrane
B0000422biological_processautophagy of mitochondrion
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005776cellular_componentautophagosome
B0005790cellular_componentsmooth endoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005875cellular_componentmicrotubule associated complex
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0006605biological_processprotein targeting
B0006914biological_processautophagy
B0006915biological_processapoptotic process
B0006995biological_processcellular response to nitrogen starvation
B0007268biological_processchemical synaptic transmission
B0008017molecular_functionmicrotubule binding
B0008429molecular_functionphosphatidylethanolamine binding
B0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
B0012505cellular_componentendomembrane system
B0015031biological_processprotein transport
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0035020biological_processregulation of Rac protein signal transduction
B0048487molecular_functionbeta-tubulin binding
B0050811molecular_functionGABA receptor binding
B0097225cellular_componentsperm midpiece
B0097352biological_processautophagosome maturation
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098982cellular_componentGABA-ergic synapse
B1902524biological_processpositive regulation of protein K48-linked ubiquitination
E0000045biological_processautophagosome assembly
E0000139cellular_componentGolgi membrane
E0000226biological_processmicrotubule cytoskeleton organization
E0000421cellular_componentautophagosome membrane
E0000422biological_processautophagy of mitochondrion
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005776cellular_componentautophagosome
E0005790cellular_componentsmooth endoplasmic reticulum
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005874cellular_componentmicrotubule
E0005875cellular_componentmicrotubule associated complex
E0005886cellular_componentplasma membrane
E0005930cellular_componentaxoneme
E0006605biological_processprotein targeting
E0006914biological_processautophagy
E0006915biological_processapoptotic process
E0006995biological_processcellular response to nitrogen starvation
E0007268biological_processchemical synaptic transmission
E0008017molecular_functionmicrotubule binding
E0008429molecular_functionphosphatidylethanolamine binding
E0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
E0012505cellular_componentendomembrane system
E0015031biological_processprotein transport
E0015629cellular_componentactin cytoskeleton
E0016020cellular_componentmembrane
E0031410cellular_componentcytoplasmic vesicle
E0031625molecular_functionubiquitin protein ligase binding
E0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
E0035020biological_processregulation of Rac protein signal transduction
E0048487molecular_functionbeta-tubulin binding
E0050811molecular_functionGABA receptor binding
E0097225cellular_componentsperm midpiece
E0097352biological_processautophagosome maturation
E0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
E0098982cellular_componentGABA-ergic synapse
E1902524biological_processpositive regulation of protein K48-linked ubiquitination
G0000045biological_processautophagosome assembly
G0000139cellular_componentGolgi membrane
G0000226biological_processmicrotubule cytoskeleton organization
G0000421cellular_componentautophagosome membrane
G0000422biological_processautophagy of mitochondrion
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005764cellular_componentlysosome
G0005776cellular_componentautophagosome
G0005790cellular_componentsmooth endoplasmic reticulum
G0005794cellular_componentGolgi apparatus
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005874cellular_componentmicrotubule
G0005875cellular_componentmicrotubule associated complex
G0005886cellular_componentplasma membrane
G0005930cellular_componentaxoneme
G0006605biological_processprotein targeting
G0006914biological_processautophagy
G0006915biological_processapoptotic process
G0006995biological_processcellular response to nitrogen starvation
G0007268biological_processchemical synaptic transmission
G0008017molecular_functionmicrotubule binding
G0008429molecular_functionphosphatidylethanolamine binding
G0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
G0012505cellular_componentendomembrane system
G0015031biological_processprotein transport
G0015629cellular_componentactin cytoskeleton
G0016020cellular_componentmembrane
G0031410cellular_componentcytoplasmic vesicle
G0031625molecular_functionubiquitin protein ligase binding
G0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
G0035020biological_processregulation of Rac protein signal transduction
G0048487molecular_functionbeta-tubulin binding
G0050811molecular_functionGABA receptor binding
G0097225cellular_componentsperm midpiece
G0097352biological_processautophagosome maturation
G0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
G0098982cellular_componentGABA-ergic synapse
G1902524biological_processpositive regulation of protein K48-linked ubiquitination
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue GOL A 201
ChainResidue
AALA89
AGLN93
BGLU73
GTHR56

site_idAC2
Number of Residues6
Detailsbinding site for residue PEG E 301
ChainResidue
EHOH401
ATYR61
AALA75
ETYR61
EPHE62
ELEU76

site_idAC3
Number of Residues4
Detailsbinding site for residue PEG G 301
ChainResidue
BTYR61
BALA75
GLEU76
GHOH421

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsSITE: Interaction with LIR (LC3 nteracting Region) motif of ATG3 => ECO:0000269|PubMed:37252361, ECO:0007744|PDB:8AFI
ChainResidueDetails
AGLU17
AARG28
BGLU17
BARG28
EGLU17
EARG28
GGLU17
GARG28

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: Cleavage; by ATG4B => ECO:0000269|PubMed:15169837
ChainResidueDetails
AGLY116
BGLY116
EGLY116
GGLY116

site_idSWS_FT_FI3
Number of Residues4
DetailsLIPID: Phosphatidylserine amidated glycine; alternate => ECO:0000269|PubMed:33909989
ChainResidueDetails
AGLY116
BGLY116
EGLY116
GGLY116

224004

PDB entries from 2024-08-21

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