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7BUY

The crystal structure of COVID-19 main protease in complex with carmofur

Functional Information from GO Data
ChainGOidnamespacecontents
A0008233molecular_functionpeptidase activity
A0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue JRY A 401
ChainResidue
AHIS41
AGLY143
ASER144
ACYS145
AHIS164
ADMS402

site_idAC2
Number of Residues7
Detailsbinding site for residue DMS A 402
ChainResidue
AHIS163
AGLU166
AHIS172
AJRY401
APHE140
AASN142
ASER144

site_idAC3
Number of Residues4
Detailsbinding site for residue DMS A 403
ChainResidue
AGLY15
AMET17
AGLY71
ALYS97

site_idAC4
Number of Residues5
Detailsbinding site for residue DMS A 404
ChainResidue
AGLY2
APHE3
ALYS137
AGLY138
ALEU282

site_idAC5
Number of Residues6
Detailsbinding site for residue DMS A 405
ChainResidue
AGLU166
AARG188
AGLN189
ATHR190
AGLN192
AHOH565

site_idAC6
Number of Residues7
Detailsbinding site for residue DMS A 406
ChainResidue
AMET6
AALA7
APHE8
ASER123
AGLN127
AARG298
AHOH517

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291
ChainResidueDetails
AHIS41

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291
ChainResidueDetails
ACYS145

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
AGLN306

226707

PDB entries from 2024-10-30

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