7BUQ
mcGAS bound with 23-cGAMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0002221 | biological_process | pattern recognition receptor signaling pathway |
| A | 0002230 | biological_process | positive regulation of defense response to virus by host |
| A | 0002637 | biological_process | regulation of immunoglobulin production |
| A | 0002753 | biological_process | cytoplasmic pattern recognition receptor signaling pathway |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008289 | molecular_function | lipid binding |
| A | 0008340 | biological_process | determination of adult lifespan |
| A | 0016604 | cellular_component | nuclear body |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019933 | biological_process | cAMP-mediated signaling |
| A | 0019934 | biological_process | cGMP-mediated signaling |
| A | 0031491 | molecular_function | nucleosome binding |
| A | 0032479 | biological_process | regulation of type I interferon production |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| A | 0035861 | cellular_component | site of double-strand break |
| A | 0038001 | biological_process | paracrine signaling |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045087 | biological_process | innate immune response |
| A | 0045738 | biological_process | negative regulation of DNA repair |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050776 | biological_process | regulation of immune response |
| A | 0050863 | biological_process | regulation of T cell activation |
| A | 0051607 | biological_process | defense response to virus |
| A | 0061501 | molecular_function | 2',3'-cyclic GMP-AMP synthase activity |
| A | 0071360 | biological_process | cellular response to exogenous dsRNA |
| A | 0140693 | molecular_function | molecular condensate scaffold activity |
| A | 0140896 | biological_process | cGAS/STING signaling pathway |
| A | 0160004 | molecular_function | poly-ADP-D-ribose modification-dependent protein binding |
| A | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| A | 2000042 | biological_process | negative regulation of double-strand break repair via homologous recombination |
| A | 2000774 | biological_process | positive regulation of cellular senescence |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0002221 | biological_process | pattern recognition receptor signaling pathway |
| B | 0002230 | biological_process | positive regulation of defense response to virus by host |
| B | 0002637 | biological_process | regulation of immunoglobulin production |
| B | 0002753 | biological_process | cytoplasmic pattern recognition receptor signaling pathway |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003682 | molecular_function | chromatin binding |
| B | 0003690 | molecular_function | double-stranded DNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006281 | biological_process | DNA repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008289 | molecular_function | lipid binding |
| B | 0008340 | biological_process | determination of adult lifespan |
| B | 0016604 | cellular_component | nuclear body |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019933 | biological_process | cAMP-mediated signaling |
| B | 0019934 | biological_process | cGMP-mediated signaling |
| B | 0031491 | molecular_function | nucleosome binding |
| B | 0032479 | biological_process | regulation of type I interferon production |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0035861 | cellular_component | site of double-strand break |
| B | 0038001 | biological_process | paracrine signaling |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0045087 | biological_process | innate immune response |
| B | 0045738 | biological_process | negative regulation of DNA repair |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050776 | biological_process | regulation of immune response |
| B | 0050863 | biological_process | regulation of T cell activation |
| B | 0051607 | biological_process | defense response to virus |
| B | 0061501 | molecular_function | 2',3'-cyclic GMP-AMP synthase activity |
| B | 0071360 | biological_process | cellular response to exogenous dsRNA |
| B | 0140693 | molecular_function | molecular condensate scaffold activity |
| B | 0140896 | biological_process | cGAS/STING signaling pathway |
| B | 0160004 | molecular_function | poly-ADP-D-ribose modification-dependent protein binding |
| B | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| B | 2000042 | biological_process | negative regulation of double-strand break repair via homologous recombination |
| B | 2000774 | biological_process | positive regulation of cellular senescence |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | HIS378 |
| A | CYS384 |
| A | CYS385 |
| A | CYS392 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 1SY A 602 |
| Chain | Residue |
| A | ARG364 |
| A | SER366 |
| A | SER368 |
| A | GLU371 |
| A | HOH701 |
| A | ILE206 |
| A | MET215 |
| A | ASP307 |
| A | ILE309 |
| A | LYS350 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 601 |
| Chain | Residue |
| B | HIS378 |
| B | CYS384 |
| B | CYS385 |
| B | CYS392 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue 1SY B 602 |
| Chain | Residue |
| B | GLU211 |
| B | ASP213 |
| B | MET215 |
| B | PRO292 |
| B | ASP307 |
| B | ILE309 |
| B | VAL348 |
| B | LYS350 |
| B | ARG364 |
| B | SER366 |
| B | SER368 |
| B | CYS419 |
| B | TYR421 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23647843 |
| Chain | Residue | Details |
| A | GLU211 | |
| A | ASP213 | |
| A | ASP307 | |
| A | GLU371 | |
| A | LYS402 | |
| A | SER420 | |
| B | THR197 | |
| B | SER199 | |
| B | GLU211 | |
| B | ASP213 | |
| B | ASP307 | |
| B | GLU371 | |
| B | LYS402 | |
| B | SER420 | |
| A | THR197 | |
| A | SER199 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24332030, ECO:0007744|PDB:4LEZ |
| Chain | Residue | Details |
| A | ARG364 | |
| B | GLY290 | |
| B | LYS350 | |
| B | ARG364 | |
| A | GLY290 | |
| A | LYS350 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6X59, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
| Chain | Residue | Details |
| B | CYS384 | |
| A | HIS378 | |
| A | CYS384 | |
| B | HIS378 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6XJD, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
| Chain | Residue | Details |
| B | CYS385 | |
| A | CYS385 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911480, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6X5A, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
| Chain | Residue | Details |
| A | CYS392 | |
| B | CYS392 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Arginine-anchor => ECO:0000269|PubMed:31808743, ECO:0000269|PubMed:32911480, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000 |
| Chain | Residue | Details |
| A | ARG241 | |
| B | ARG241 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by CASP3 => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | ASP307 | |
| B | ASP307 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| B | THR52 | |
| A | THR52 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:35460603 |
| Chain | Residue | Details |
| B | GLU176 | |
| A | GLU176 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| B | SER199 | |
| A | SER199 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | TYR201 | |
| B | TYR201 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:26829768 |
| Chain | Residue | Details |
| B | GLU272 | |
| A | GLU272 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CDK1 and PKB => ECO:0000269|PubMed:26440888, ECO:0000269|PubMed:32351706 |
| Chain | Residue | Details |
| B | SER291 | |
| A | SER291 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl glutamate => ECO:0000269|PubMed:26829768 |
| Chain | Residue | Details |
| B | GLU302 | |
| A | GLU302 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS402 | |
| B | LYS372 | |
| B | LYS382 | |
| B | LYS402 | |
| A | LYS382 | |
| A | LYS372 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:32474700 |
| Chain | Residue | Details |
| B | SER420 | |
| A | SER420 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:35210392 |
| Chain | Residue | Details |
| A | LYS491 | |
| B | LYS491 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 6 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | CYS459 | |
| B | CYS392 | |
| B | CYS393 | |
| B | CYS459 | |
| A | CYS392 | |
| A | CYS393 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:27637147 |
| Chain | Residue | Details |
| B | LYS217 | |
| A | LYS217 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27637147, ECO:0000269|PubMed:32457395 |
| Chain | Residue | Details |
| B | LYS464 | |
| A | LYS464 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27637147, ECO:0000269|PubMed:32457395 |
| Chain | Residue | Details |
| A | LYS271 | |
| B | LYS271 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:29426904 |
| Chain | Residue | Details |
| A | LYS335 | |
| B | LYS335 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS372 | |
| B | LYS372 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:28095500 |
| Chain | Residue | Details |
| A | LYS382 | |
| B | LYS382 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| B | LYS399 | |
| B | LYS402 | |
| A | LYS399 | |
| A | LYS402 |
