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7BSW

Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdEtn-occluded E2-AlF state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0005215molecular_functiontransporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0012505cellular_componentendomembrane system
A0015914biological_processphospholipid transport
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0031901cellular_componentearly endosome membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0045332biological_processphospholipid translocation
A0046872molecular_functionmetal ion binding
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0090555molecular_functionphosphatidylethanolamine flippase activity
A0090556molecular_functionphosphatidylserine floppase activity
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140331biological_processaminophospholipid translocation
A0140346molecular_functionphosphatidylserine flippase activity
A1990531cellular_componentphospholipid-translocating ATPase complex
C0005198molecular_functionstructural molecule activity
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006855biological_processxenobiotic transmembrane transport
C0006869biological_processlipid transport
C0010976biological_processpositive regulation of neuron projection development
C0015247molecular_functionaminophospholipid flippase activity
C0015917biological_processaminophospholipid transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0030658cellular_componenttransport vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0031901cellular_componentearly endosome membrane
C0031902cellular_componentlate endosome membrane
C0035577cellular_componentazurophil granule membrane
C0035579cellular_componentspecific granule membrane
C0036010biological_processprotein localization to endosome
C0045332biological_processphospholipid translocation
C0061092biological_processpositive regulation of phospholipid translocation
C0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
C0140331biological_processaminophospholipid translocation
C1990531cellular_componentphospholipid-translocating ATPase complex
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
AASP409-THR415

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues198
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APHE64-VAL82
ATRP1067-LEU1087
ATHR84-ILE104
AILE288-THR308
APHE344-GLU364
APHE877-PHE897
AALA906-LEU926
ALEU953-GLY973
ATRP993-LEU1013
APHE1024-ILE1044

site_idSWS_FT_FI2
Number of Residues81
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AASP83
ALEU309-ASP343
ASER898-ALA905
ATHR974-ASN992
ATRP1045-THR1066

site_idSWS_FT_FI3
Number of Residues727
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ALYS105-SER287
AMET365-TYR876
AGLU927-GLN952
AASP1014-HIS1023

site_idSWS_FT_FI4
Number of Residues1
DetailsACT_SITE: 4-aspartylphosphate intermediate => ECO:0000250|UniProtKB:Q9Y2Q0
ChainResidueDetails
AASP409

site_idSWS_FT_FI5
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9Y2Q0
ChainResidueDetails
AASP409
ALYS410
ATHR411
APHE540
AASN819

site_idSWS_FT_FI6
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04191
ChainResidueDetails
AGLU498
ALYS563
AARG594
ATHR674
AGLY675
AASP676
AARG789
ALYS795

site_idSWS_FT_FI7
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:32493773, ECO:0007744|PDB:6LKN
ChainResidueDetails
AASP816
AASP820

site_idSWS_FT_FI8
Number of Residues1
DetailsSITE: Cleavage; by CASP3, CASP6 and CASP7 => ECO:0000269|PubMed:24904167
ChainResidueDetails
AASP439

site_idSWS_FT_FI9
Number of Residues1
DetailsSITE: Cleavage; by CASP3 => ECO:0000269|PubMed:24904167
ChainResidueDetails
AASP445

site_idSWS_FT_FI10
Number of Residues1
DetailsSITE: Cleavage; by CASP3 and CASP7 => ECO:0000269|PubMed:24904167
ChainResidueDetails
AASP481

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER442

219515

PDB entries from 2024-05-08

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