Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7BRU

Crystal structure of human RTN3 LIR fused to human GABARAP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000139	cellular_component	Golgi membrane
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000421	cellular_component	autophagosome membrane
A	0000423	biological_process	mitophagy
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005875	cellular_component	microtubule associated complex
A	0005886	cellular_component	plasma membrane
A	0005930	cellular_component	axoneme
A	0006605	biological_process	protein targeting
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006995	biological_process	cellular response to nitrogen starvation
A	0007268	biological_process	chemical synaptic transmission
A	0008017	molecular_function	microtubule binding
A	0008429	molecular_function	phosphatidylethanolamine binding
A	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
A	0012505	cellular_component	endomembrane system
A	0015031	biological_process	protein transport
A	0015629	cellular_component	actin cytoskeleton
A	0031410	cellular_component	cytoplasmic vesicle
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0035020	biological_process	regulation of Rac protein signal transduction
A	0048487	molecular_function	beta-tubulin binding
A	0050811	molecular_function	GABA receptor binding
A	0097225	cellular_component	sperm midpiece
A	0097352	biological_process	autophagosome maturation
A	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A	0098982	cellular_component	GABA-ergic synapse
A	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
B	0000045	biological_process	autophagosome assembly
B	0000139	cellular_component	Golgi membrane
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000421	cellular_component	autophagosome membrane
B	0000423	biological_process	mitophagy
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0005790	cellular_component	smooth endoplasmic reticulum
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005875	cellular_component	microtubule associated complex
B	0005886	cellular_component	plasma membrane
B	0005930	cellular_component	axoneme
B	0006605	biological_process	protein targeting
B	0006914	biological_process	autophagy
B	0006915	biological_process	apoptotic process
B	0006995	biological_process	cellular response to nitrogen starvation
B	0007268	biological_process	chemical synaptic transmission
B	0008017	molecular_function	microtubule binding
B	0008429	molecular_function	phosphatidylethanolamine binding
B	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
B	0012505	cellular_component	endomembrane system
B	0015031	biological_process	protein transport
B	0015629	cellular_component	actin cytoskeleton
B	0031410	cellular_component	cytoplasmic vesicle
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0035020	biological_process	regulation of Rac protein signal transduction
B	0048487	molecular_function	beta-tubulin binding
B	0050811	molecular_function	GABA receptor binding
B	0097225	cellular_component	sperm midpiece
B	0097352	biological_process	autophagosome maturation
B	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B	0098982	cellular_component	GABA-ergic synapse
B	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
C	0000045	biological_process	autophagosome assembly
C	0000139	cellular_component	Golgi membrane
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000421	cellular_component	autophagosome membrane
C	0000423	biological_process	mitophagy
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0005790	cellular_component	smooth endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005875	cellular_component	microtubule associated complex
C	0005886	cellular_component	plasma membrane
C	0005930	cellular_component	axoneme
C	0006605	biological_process	protein targeting
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006995	biological_process	cellular response to nitrogen starvation
C	0007268	biological_process	chemical synaptic transmission
C	0008017	molecular_function	microtubule binding
C	0008429	molecular_function	phosphatidylethanolamine binding
C	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
C	0012505	cellular_component	endomembrane system
C	0015031	biological_process	protein transport
C	0015629	cellular_component	actin cytoskeleton
C	0031410	cellular_component	cytoplasmic vesicle
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0035020	biological_process	regulation of Rac protein signal transduction
C	0048487	molecular_function	beta-tubulin binding
C	0050811	molecular_function	GABA receptor binding
C	0097225	cellular_component	sperm midpiece
C	0097352	biological_process	autophagosome maturation
C	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C	0098982	cellular_component	GABA-ergic synapse
C	1902524	biological_process	positive regulation of protein K48-linked ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PO4 A 201

Chain	Residue
A	LYS12
A	ASP16
A	ASN103
A	HIS120
A	HOH314
A	HOH329
B	GLN81

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 B 201

Chain	Residue
B	PRO32
B	LYS35
B	LYS35
A	GLY1
A	GLY1

site_id	AC3
Number of Residues	2
Details	binding site for residue PO4 B 202

Chain	Residue
B	HIS31
B	HOH312

site_id	AC4
Number of Residues	5
Details	binding site for residue PO4 B 203

Chain	Residue
B	LYS12
B	ASP16
B	ASN103
B	GLU119
B	HIS120

site_id	AC5
Number of Residues	7
Details	binding site for residue PO4 C 201

Chain	Residue
A	TYR27
A	HIS31
A	GLU39
A	LYS70
A	HOH306
C	GLU3
C	SER4

site_id	AC6
Number of Residues	6
Details	binding site for residue PO4 C 202

Chain	Residue
A	GLN81
B	LYS46
C	LYS12
C	ASP16
C	HIS120
C	HOH304

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	Region: {"description":"Interaction with beta-tubulin","evidences":[{"source":"PubMed","id":"9892355","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	96
Details	Region: {"description":"Interaction with GABRG2","evidences":[{"source":"PubMed","id":"9892355","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Region: {"description":"Interaction with LIR (LC3 nteracting Region) motif of ATG3","evidences":[{"source":"PubMed","id":"37252361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Interaction with LIR (LC3 nteracting Region) motif of ATG3","evidences":[{"source":"PubMed","id":"37252361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Lipidation: {"description":"Phosphatidylserine amidated glycine; alternate","evidences":[{"source":"PubMed","id":"33909989","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)